Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"lipocalin"”.
-
Role of Bacterial Lipocalin Proteins in Antimicrobial Resistance
… fibrosis, produces the extracellular bacterial lipocalin protein BcnA upon exposure to<br/>sublethal concentrations of bactericidal antibiotics. BcnA captures a range of antibiotics outside bacterial cells, providing a global extracellular mechanism of antimicrobial resistance. In this thesis, I …
-
ROLE OF LIPOCALIN 2 IN KAINATE-INDUCED NEURODEGENERATION
Lipocalin 2 (LCN2) is a member of the lipocalin family, which has diverse roles in infections, iron homeostasis, apoptosis, tumourigenesis, inflammation, renal physiology and pathology. Yet, little is known about the functions of LCN2 in the central nervous system (CNS). In view of recent studies …
-
Lipocalin 2 Promotes The Establishment of A Pro-Tumorigenic Microenvironment In Pancreatic Cancer
<p>Pancreatic ductal adenocarcinoma (PDAC) is a disease characterized by a dismal prognosis with a 5-year survival rate of 7%. A unique hallmark of this disease is an abundant desmoplastic reaction that can account for up to 90% of the solid tumor volume. Key components of the PDAC stroma include …
-
Neutrophil gelatinase-associated lipocalin (NGAL) and matrix metalloproteinases (MMPs) as biomarkers of bladder cancer development and progression
Neutrophil gelatinase-associated lipocalin (NGAL), also called lipocalin-2, is a secreted protein belonging to the lipocalin family proteins and actively participates into the proliferation, differentiation, and development of human tissues, including tumours. It positively modulates the activity …
-
Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
Lipocalin-2 (LCN-2) ist eine pleiotrope 25-kDa sekretorischen Proteins, das derzeit als Biomarker für Nierenschäden und Entzündungen eingesetzt. Sein Serumspiegel unter verschiedenen pathologischen Bedingungen erhöht, aber die Quelle und Ursache sind unklar. Das Ziel unserer Studie war es, zur …
-
Discovery and validation of novel blood biomarkers of breast and prostate cancer
… biomarker potential of five proteins: Serpin B1, Lipocalin 2, Copine 3, Integrin 4 and 5LOX, using Western blot, immunofluorescence, flow cytometry and ELISA techniques. Serpin B1, Lipocalin 2, 5LOX and Copine 3 were present in neutrophils, whereas Integrin 4 was detected in T-lymphocytes. …
-
Observing Renal Responses to Endurance Cycling in the Heat
… measure serum neutrophil gelatinase-associated lipocalin. RESULTS: A net fluid loss of 1.3 ± 1.1 kg was observed. Urine specific gravity (P < 0.001) and leg muscle pain (P < 0.001) increased post-event. Serum creatinine increased from pre- (0.52 ± 0.14 mg/dL) to post-event (0.88 ± 0.21 mg/dL; P …
-
Changes in tear film biochemistry in end of day ocular discomfort with and without contact lenses
… of five proteins (lysozyme, lactoferrin, lipocalin 1, prolactin-induced protein and proline rich 4) in 2.5 microlitres of tears was achieved using a novel method based on selected reaction monitoring (SRM) mass spectrometry. The concentrations of prolactin-induced protein, proline rich …
-
The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… to identify and characterise the expression of lipocalin 2, a novel GC-responsive chondrocyte gene which may contribute to GC-induced growth retardation in the growth plate. In vitro and in vivo studies have also been used to examine the role of the cell cycle regulator, p21WAF1/CIP1 in …
-
Obesity in Patients with Inflammatory Bowel Disease // Затлъстяване при пациенти с хронични възпалителни болести на червата
… hand, recently, circulating levels of human Lipocalin-2/NGAL have been successfully linked as a tool to monitor activity and response to treatment in patients with immune-mediated diseases. The absence of data combining the results of these new noninvasive markers in the study of patients …
-
Predictive Role of NGAL – Neutrophil Gelatinase-Associated Lipocalin as an Early Marker for Renal Injury in Patients with Diabetes Mellitus Type 1 And Type 2 // Предиктивна роля на NGAL – неутрофил гелатиназа асоцииран липокалин като ранен маркер за бъбречно увреждане при пациенти със ЗД тип 1 и ЗД тип 2
Дисертационният труд разглежда ролята на Неутрофил гелатиназа-асоцииран липокалин (NGAL) като маркер за бъбречно увреждане при пациенти със захарен диабет (ЗД). Съществен принос са определените възрастово и полово диференцирани референтни граници на pNGAL, uNGAL и uNGAL/uCreatinine (UNC) за …
-
Acute Nitrate Exposure Causes Proteomic Changes Consistent with the Regulation of Reactive Oxygen and Nitrogen Species
… (enolase), transport of hydrophobic molecules (lipocalin) and cytoskeletal arrangements (intermediate filaments and a gelsolin-like adseverin). The most parsimonious explanation for these changes in protein expression assumes that C. gigas reduces nitrate to nitrite and nitric oxide, which …
-
Structural and functional studies of heme binding proteins toward the understanding of malaria
… in vivo localization studies. MFP is a putative lipocalin-like protein that we have identified as binding both an [Fe-S] cluster and a heme moiety. We show that the [4Fe-4S] cluster of MFP inhibits heme binding to the protein and have proposed a potential structural model to explain this finding. …
-
Migration Stimulating Factor, the search for inhibitors.
… inhibitor as Neutrophil Gelatinase Associated Lipocalin (NGAL). Both recombinant and cell-produced NGAL neutralise the motogenic activity of MSF. This novel bioactivity for NGAL is not dependent on its iron transportation capability or direct binding to MSF. HaCaT cells also secrete MSF; the …
-
The molecular effects of low dose fractionated radiation treatment on Ovarian Adenocarcinoma
… element (ERE) and one of its target genes, Lipocalin 2, which is known to be involved in the growth and differentiation of cells, were not induced as a result of LDFRT, but induction was observed after treatment with a single dose of 2 Gy radiation. This observation indicates a possible …
-
Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… (ARG1), Keratin Type-2 Cytoskeletal 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification by immunochemical methods which further supported the …
-
Proteomic profiling of matched normal and tumour tongue biopsies from smokers and non-smokers. Oncoproteomic applications for oral tongue squamous cell carcinoma biomarker discovery
… (ARG1), Keratin Type-2 Cytoskeletal 8 (KRT8), Lipocalin-1 (LCN1) and DNA replication licensing factor MCM2 (MCM2) were identified as biologically associated with smoking compared to non-smoking, providing viable targets for verification by immunochemical methods which further supported the …
-
Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
… resistin and neutrophil gelatinase-associated lipocalin) and cytoplasmic (cyclophilin A) proteins under hypoxia. Furthermore, a plasma signature of increased protease (NE and proteinase 3) activity was identified in COPD versus healthy control plasma. In conclusion, hypoxia engenders a …
-
Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… of neutrophil gelatinase associated lipocalin (NGAL), an antibacterial protein positively correlated with UC severity. Accordingly, we hypothesized that CA would upregulate the NRF2 and decrease inflammation in intestinal inflammation models. We used UC patient-derived colonoids and …
-
Proteomic analysis of the olfactory mucosa, thoracic aorta, urinary bladder, and descending colon of smooth muscle alpha actin null mutant mice
… of vomeronasal secretory proteins I and II, and lipocalin 13 precursor. In the thoracic aorta of SMAA null mice, levels of skeletal muscle myosin essential and regulatory light chain, along with gamma actin, were increased, whereas levels of alpha cardiac muscle actin were decreased. In the …
Page 1 of 2