Global ETD Search
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Showing 1 to 6 of 6 for “"lipoate protein ligase"”.
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Studies on lipoic acid metabolism
… an octanoyl moiety from the acyl carrier protein (ACP) of fatty acid biosynthesis to the LDs. A thioester-bound acyl-enzyme intermediate is formed in the process. Then lipoyl synthase (LipA) catalyzes replacement of single hydrogen atoms at carbons 6 and 8 with sulfur atoms using radical …
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Post-Translational Modification With Lipoic Acid in Escherichia Coli
… the specific lysine residues of the apoprotein subunits of these complexes. The first pathway identified involves the lplA (lipoate-protein ligase) gene product, which utilizes free lipoic acid found in the environment to modify apoproteins. A second pathway was known to be dependent on …
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Lipoic acid assembly on 2-oxoacid dehydrogenases in E.coli
… dependent on the activities of the LipB and LipA proteins and a lipoic acid scavenging pathway catalyzed by the LplA protein. LipB is responsible for octanoylation of the E2 components of 2-oxoacid dehydrogenases to provide the substrates of LipA, a SAM radical enzyme that inserts two sulfur atoms …
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Lipoic acid protein ligases in Plasmodium spp.
… the biochemical characterisation of lipoic acid ligases and can be adapted to high-throughput screening approaches of inhibitors for these enzymes. Lipoic acid, also known as 6,8-thioctic acid, is an essential cofactor of alpha-keto acid dehydrogenase complexes (KADH) and the glycine cleavage …
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Lipoic acid metabolism in Leishmania major
… In silico analyses identified genes encoding for proteins involved in both LA biosynthesis and salvage (lipoic acid synthase (LIPA), octanoyl-[acyl carrier protein]: protein N-octanoyltransferase (LIPB) and lipoate protein ligase (LPLA), respectively), and it was predicted that all three proteins …
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Studies of lipoic acid and biotin metabolism in bacteria and higher eukaryotes
… dehygrogenase (OADH) and glycine cleavage H protein (GcvH). There they act as “swinging arms” that transfer intermediates between two active sites of key metabolic enzymes by covalent substrate channeling. Escherichia coli and Bacillus subtilis are the two organisms with well characterized …