Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"lipid toxicity"”.
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Deciphering Cancer Metabolic Dependencies in the Tumor Microenvironment
… the metabolic dependencies of cancer cells under lipid saturation stress and characterize the in vivo specific metabolic liabilities of pancreatic tumors. Cells require a constant supply of fatty acids to survive and proliferate but excess levels of fatty acids, specifically saturated lipids, are …
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INDUCED PLURIPOTENT STEM CELL DERIVED LIVER MODEL FOR THE STUDY OF PNPLA3-ASSOCIATED NON-ALCOHOLIC FATTY LIVER DISEASE
… fatty acids to induce NAFLD-like phenotypes (lipid accumulation and lipid toxicity, respectively) and characterized by various functional, genomic, and lipidomic assays. The genetically edited sublines showed similar differentiation efficiency toward hepatocytes as untargeted cells indicating …
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Design of hybrid retroviral/synthetic gene delivery vectors
… of synthetic polymer-based – chitosan (χ¬) and lipid-based (φ) envelopes for Moloney Murine Leukemia Virus (MLV) -like particles (M-VLPs). M-VLPs are essentially intact viruses lacking the envelope protein most necessary for transfection, thus making them inactive. Both chitosan and liposomes …