Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"lipid signaling"”.
-
Lipid Signaling Under Microgravity Conditions
… This response involves a complex interplay among signaling molecules, most of which are represented by endogenous bioactive lipids such as endocannabinoids, sphingolipids, eicosanoids, and specialized pro-resolving mediators (SPMs). Each signal plays a role in different phases of the inflammatory …
-
Membrane Surface Charge and Lipid Signaling in Phagocytosis
… reorganization and membrane remodeling. Lipids are increasingly appreciated to play a crucial role in these events. Sphingolipids, cholesterol and glycerophospholipids, notably the phosphoinositides, are required for the segregation of signaling microdomains and for the generation of …
-
Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1
Phosphoinositides are key lipid signaling molecules present in membranes of all eukaryotes. Different species of phosphoinositides serve as membrane signposts at distinct cellular compartments. This assymetric distribution of phosphoinositides is achieved by the presence of an elaborate set of …
-
Evaluating Phosphatidylinositide as Lipid Biomarkers for Hyperglycemia-related Triple-negative Breast Cancer Aggressiveness
… levels influence TNBC behavior and whether lipid signaling molecules at the cell membrane, known as phosphatidylinositol lipids (PIs), can serve as biomarkers of disease progression. To address this, we combined functional assays that measure key cancer traits, including cell migration, …
-
Receptor-mediated calcium entry in retinal amacrine cells
… receptors linked to phospholipase C. The signaling pathway engendered by activation of this enzyme can involve Ca<sup>2+</sup>-permeable transient receptor potential (TRP) channels. To begin to understand the role of these channels in the retina, we undertake an immunocytochemical …
-
Maternal Exposure to Prostaglandin E2 Affects Hippocampal Synaptic Plasticity in Mice Offspring -A Link to Autism Spectrum Disorder
Prostaglandin E2 (PGE2) is a lipid signaling molecule involved in early healthy brain development. Exposure to environmental risk factors such as air pollutants, infections, and drugs such as acetaminophen during early pregnancy have shown to impact PGE2 levels and have all been linked to Autism …
-
MOLECULAR REGULATION OF ATP-CITRATE LYASE
… cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the nucleus, acetyl-CoA is used for histone acetylation, which is particularly sensitive to glucose availability and ACLY deficiency. ACLY protein is present in both the …
-
Development of Novel, Brain Permeable, mPGES-1 Inhibitors for Inflammatory Conditions
… E2 (PGE2) is a potent proinflammatory lipid signaling molecule produced downstream of the cyclooxygenase (COX) cascade. The COX pathway has long been implicated for its role in inflammation, with drugs like aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) non-selectively …
-
Characterization of Novel CB2 Agonist SMM-295 and Its Effects in Ischemia/Reperfusion Injury
… cannabinoid type 1 and 2 receptors, endogenous lipid signaling molecules, N-arachidonoyl ethanolamine (AEA) and 2-acylglycerol, and the enzymes involved in their biosynthesis and catabolism. In the kidney, the CB1 receptors consistently demonstrate deleterious effects on glomerular and tubular …
-
Integrin Modulating Factor 1 (IMF-1): A lipid that modulates leukocyte integrins
… This thesis describes an acidic, amphiphilic lipid, termed integrin modulating factor (IMF-1), that may serve to control CR3 avidity. Addition of IMF-1 to cells or to purified CR3 causes enhanced binding of ligand. IMF-1 cannot be extracted from resting PMN but can be extracted from cells …
-
Tobacco Phospholipase D β1: Molecular Cloning and Biochemical Characterization
Transgenic tobacco plants were developed containing a partial PLD clone in antisense orientation. The PLD isoform targeted by the insertion was identified. A PLD clone was isolated from a cDNA library using the partial PLD as a probe: Nt10B1 shares 92% identity with PLDβ1 from tomato but lacks the …
-
Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid content and responsiveness to …
-
Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
Lipids and proteins are two major components of cells, which are crucial for structural integrity and maintenance of cellular homeostasis by integrating various extracellular and intracellular cues. Lipids are involved in the regulation of cellular functions and can interact with proteins and …
-
Molecular characterization of signaling mechanisms in flowering transition in arabidopsis and association mapping of temperature response in floral development within glycine soja
… polyphosphate 5-phosphatase involved in phospholipid signaling, interacts with TFL1 at a key functional residue. Both overexpressed TFL1 and mutant tfl1-1 are revealed to have increased sensitivity to root gravitropism similar to 5PTase13. While 5ptase single and double mutants do not exhibit a …