Global ETD Search
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Showing 1 to 20 of 85 for “"lipid rafts"”.
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Lipid rafts in protein sorting and yeast cell polarity
… Network, TGN. This organelle sorts proteins and lipids into vesicular transport carriers that are targeted via different pathways to distinct membrane compartments of the cell. The molecular principles that operate in cargo sorting at the TGN are still not very well understood. Especially, we …
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Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… major component of membrane microdomains, termed lipid rafts. Numerous signaling and transport proteins have been found to be targeted to lipid raft microdomains, where the function of the associated membrane proteins could be distinctly regulated. I have identified the expression of lipid raft …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… localizes to discrete membrane microdomains (lipid rafts) in cell lines that are resistant to EGFR TKI-induced growth inhibition. Depletion of lipid rafts via cholesterol reduction results in sensitivity of EGFR TKI resistant breast cancer cell lines to the EGFR TKI gefitinib. Importantly, the …
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Molekulare Grundlage des Kongenitalen Nephrotischen Syndroms : Podocin rekrutiert Nephrin in Lipid Rafts
… für die Rekrutierung von Nephrin in Lipid Rafts. Im Gegensatz dazu waren die krankheitsverursachenden Podocin-Mutationen (R138Q und R138X) nicht in der Lage, Nephrin in Lipid Rafts zu rekrutieren. Dies lag entweder daran, dass die Mutation im Endoplasmatischen Retikulum zurückgehalten …
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Die Regulation von humanen Natürlichen Killerzellen : regulierte SAP-Expression und die Rolle der Lipid Rafts
… spielen spezielle Membranbereiche, die sog. Lipid Rafts, eine essentielle Rolle. NKG2D wurde nach Ligandenbindung in diese Membranbereiche rekrutiert. Nach biochemischer Zerstörung der Lipid Rafts war die NKG2D-vermittelte NK Zell Aktivierung blockiert. Es konnte gezeigt werden, dass …
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The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… postural instability and slowness of movement. Lipid rafts enriched glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipid and cholresterol, are specialized microdomains that play a role in endocytosis, exocytosis, signal transduction and receptor traffic king. The disruption of …
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The regulation of yeast homotypic vacuole fusion and membrane trafficking events by sphingolipids, ergosterol, and lipid rafts
… process requires a minimal set of proteins and lipids in fully reconstituted systems, but in vivo fusion is a highly regulated process, with inputs from multiple signaling pathways. In live cells, membrane fusion requires the activity of SNAREs, small GTPases, chaperones, tethering complexes, …
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Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… seeks to demonstrate that MCHR-1 is enriched in lipid rafts and that a possible consequence of this may be altered signal transduction in obese individuals, such as downregulated ERK 1/2-mediated leptin transcription. Increased amounts of adipose tissue, and thus caveolae, may play a central role …
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Investigating crosstalk in lipid rafts between the glucocorticoid receptor and gonadotropin-releasing hormone receptor signaling pathways in a gonadotrope cell line
… the co-localization of these receptors to lipid rafts, providing a specialized distinct region where the receptors can be in close proximity and reciprocally modulate each other’s signaling pathways.
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IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… evidence suggests a potential role of membrane lipids especially cholesterol in regulation of psychostimulant-mediated GPCR signaling. Plasma membrane is organized into cholesterol-enriched lipid raft and non-lipid raft microdomains. GPCRs and their interactinG-proteins are localized in lipid …
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Understanding the Mechanism of Action of Rituximab in the Reversal of Multidrug Resistance in a Non-Hodgkins Lymphoma Cell Line
… into a detergent-insoluble embrane compartment (lipid rafts). By redistributing CD20 into rafts, Rituximab(tm) (RTX) modified their stability and organization. P-glycoprotein (P-gp) is the constituent protein of MDR tumor cells and is responsible for pumping chemotherapeutic agents out of cells. …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… which contains different microdomains called lipid rafts. In this thesis, specific Src/FAK biosensors based on fluorescence resonance energy transfer (FRET) were developed and further targeted to subcompartments of plasma membrane to visualize local Src/FAK signaling events in live cells with …
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Characterization of a Novel GPI-anchored Protein, a Component of Sphingomyelin-enriched Microdomains at the Golgi Complex
… along the secretory pathway to sort proteins and lipids to their final destinations. It exists of a series of flattened cisternal membranes that are aligned in parallel to form polarized stacks. This structure is actively maintained amid a large flow of biosynthetic transports through the …
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The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip
… in increased levels of Fas within the membrane lipid rafts, as demonstrated by an increase in Fas expression in detergent insoluble lipid raft fractions. We further demonstrated that following MS-275 treatment, Fas colocalized with GM1<sup>+</sup> lipid rafts and that there was a decrease in …
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Functional characterisation of the lipid raft protein stomatin
… its role in the cell. The membranes and lipid rafts of stomatocytes were found to have reduced actin levels as compared to erythrocytes, suggesting that stomatin may function as a structural protein linking the cytoskeleton to the membrane. Overexpression of stomatin in nucleated cells …
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Vaccinia Virus Binding and Infection of Primary Human Leukocytes
… PHLs. VV binding strongly co-localized with lipid rafts on the surface of these cell types, even when lipid rafts were relocated to the cell uropods upon cell polarization. In humans, monocytic and professional antigen-presenting cells (APCs) have so far only been reported to exhibit abortive …
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CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… be achieved through activation of platelets. Lipid rafts are distinct areas of the plasma membrane implicated in the regulation of signaling in a variety of cells including platelets. A previous study C-type lectin like receptor 2 (CLEC-2) has been reported to activate platelets through a …
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The Role of Sulfatide in Alzheimer's Disease
… sequestered to membrane domains called lipid rafts. Sulfatide (ST) is a glycosphingolipid that is essential for the proper structure and function of lipid rafts. In mice that lack ST, membrane domains that are normally maintained by adhesive contacts and functional lipid rafts are …
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Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… by a mechanism mediated by an association with lipid microdomains known as lipid rafts. Lipid rafts and their associated proteins are operationally defined by their resistance to detergent solubilization at cold temperatures. By systematic mutagenesis of the transmembrane domain of …
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