Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"lipid raft"”.
-
Functional characterisation of the lipid raft protein stomatin
… its role in the cell. The membranes and lipid rafts of stomatocytes were found to have reduced actin levels as compared to erythrocytes, suggesting that stomatin may function as a structural protein linking the cytoskeleton to the membrane. Overexpression of stomatin in nucleated cells …
-
Lipid raft signaling in cofilin-actin rod formation induced by amyloid-β and TNFα
… by the cellular prion protein, a component of lipid raft domains which can signal to activate NADPH oxidase. Lipid rafts are cholesterol/sphingolipid enriched detergent resistant membrane domains in which many membrane receptors associate. Rafts can be visualized with an Alexa labeled cholera …
-
Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
<p>FUNCTIONAL IN VITRO ANALYSES OF LIPID RAFT-ASSOCIATED CATHEPSIN B: IMPLICATION FOR THE INVASIVE PHENOTYPE </p> <p>OF INFLAMMATORY BREAST CANCER</p> <p>by</p> <p>BERNADETTE C. VICTOR</p> <p>December 2011</p> <p>Advisor: Dr. Bonnie F. Sloane</p> <p>Major: Cancer Biology </p> <p>Degree: Doctor of …
-
Melanin-Concentrating Hormone Receptor-1 is Enriched in Lipid Rafts and the Effects of Lipid Raft Integrity on Receptor Signaling
… seeks to demonstrate that MCHR-1 is enriched in lipid rafts and that a possible consequence of this may be altered signal transduction in obese individuals, such as downregulated ERK 1/2-mediated leptin transcription. Increased amounts of adipose tissue, and thus caveolae, may play a central role …
-
Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… an enzyme involved in remodelling glycerophospholipids within cell membranes and the generation of platelet-activating factor. LPCAT2 also mediates lipopolysaccharide (LPS)-induced cytokine responses in both murine and human macrophages. Investigations into the mechanism behind LPCAT2 involvement …
-
IS BRAIN CHOLESTEROL THE MISSING CULPRIT IN DRUG ADDICTION?
… evidence suggests a potential role of membrane lipids especially cholesterol in regulation of psychostimulant-mediated GPCR signaling. Plasma membrane is organized into cholesterol-enriched lipid raft and non-lipid raft microdomains. GPCRs and their interactinG-proteins are localized in lipid …
-
Lipid Rafts in Pancreatic Beta- and Alpha-cell Stimulus-secretion Coupling
… major component of membrane microdomains, termed lipid rafts. Numerous signaling and transport proteins have been found to be targeted to lipid raft microdomains, where the function of the associated membrane proteins could be distinctly regulated. I have identified the expression of lipid raft …
-
The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… postural instability and slowness of movement. Lipid rafts enriched glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipid and cholresterol, are specialized microdomains that play a role in endocytosis, exocytosis, signal transduction and receptor traffic king. The disruption of …
-
Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma
… proliferation, cell cycle progression and lipid raft generation. These findings emphasize the potential of a combined therapy approach targeting both SREBP and mTORC1 as a novel treatment strategy for B cell lymphoma.
-
Observations in Lipid Membrane Systems
… ordered (Lo) phase. The latter exists as small “rafts” of specific lipid composition containing a host of signaling proteins. Lipid raft theory links the aggregation of rafts to a signaling event. In its current iteration, the theory is incomplete, as it does not explain how rafts form and how …
-
Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… antibody that enters the cells by caveolae/lipid-raft-mediated endocytosis. However, cell surface receptor for 3D8 scFv internalization remains unknown. Here, we studied for cell surface receptor of 3D8 scFv for cellular internalization. 3D8 scFv bound to both cell surface heparan sulfate …
-
Regulation of STAT-3 and STAT-6 by Transient Oxidative Stress in Rat Brain Astrocytes
… phosphorylation by SHP-2 activation through lipid raft. In the presence of H2O2, SHP-2 formed a complex with STAT-3, and reduced the steady-state STAT-3 phosphorylation level. H2O2 triggered SHP-2 phosphorylation in a time- and dose-dependent manner, and led to its translocation into lipid …
-
Analysis of the function and subcellular localization of FAT/CD36 in hepatocytes and transfected cell lines of hepatic and non-hepatic origin.
… (LCFAs) and is therefore a key regulator of lipid storage (particularly in adipocytes) and mitochondrial beta oxidation (particularly in muscle). Interestingly FAT/CD36 also binds native lipoproteins (including high-density lipoproteins [HDL]) with high affinity in vitro, although the …
-
Localisation and expression pattern of the Nogo receptor and its ligand, Nogo-A in cells of the mammalian central nervous system
… whether Nogo receptor is located in neuronal lipid rafts by linking it to flotillins, known lipid raft markers. We therefore generated a rabbit polyclonal Nogo receptor antibody from the leucine rich repeat number 9 domain of Nogo receptor polypeptide chain. Together with a commercially …
-
CLEC-2 SIGNAL TRANSDUCTION IN PLATELET ACTIVATION
… be achieved through activation of platelets. Lipid rafts are distinct areas of the plasma membrane implicated in the regulation of signaling in a variety of cells including platelets. A previous study C-type lectin like receptor 2 (CLEC-2) has been reported to activate platelets through a …
-
Development and evaluation of amphotericin B Loaded iron oxide nanoparticles for targeted drug delivery to systemic fungal infections
… particle uptake pathway for C. albicans was lipid-raft mediated endocytosis, whereas for C. glabrata, it was clathrin-, caveolar-, and lipid-raft-mediated endocytosis. </p> <p>TEM and confocal images provided evidence the AMB-IONP were localized at or near the cell wall and membrane wall and …
-
Plasma membrane-derived vesicles: composition and function
… trigger the release of PMVs through integrins, lipid raft microdomains and Cat' channels such as stretchactivated channels (SAC) from several cell types. Released PMVs bound to the surface of T. cruzi and abolished its complement-mediated lysis by inhibiting activation of the C3 convertase. …
-
The Role of Membrane Domains In Protein and Lipid Sorting During Endocytic Traffic
<p>The lipid and protein composition of the plasma membrane (PM) must be tightly controlled to maintain cellular functionality, despite constant, rapid endocytosis. Because <em>de novo </em>synthesis of proteins and lipids is energetically costly, the cell depends on active recycling to return …
-
Unravelling the anti-inflammatory mechanisms of dietary fatty acids
… of PUFA on CD14 was elucidated by examining lipid raft 'microdomains', the location where the receptor complex clusters upon activation. We found that treatment of macrophages with CLA reduced the incorporation of CD14 into lipid rafts following activation with LPS. We then examined …
-
Insights into the Energetics of Membrane-Bound Peptides : Towards an Understanding of the Structural Organisation of Membrane Proteins
… of its mutants is also modelled. The inefficient lipid raft localisation of the T242N mutant is proposed to be related to its helix packing. The thesis provides insight into the structural organisation and energetics of membrane proteins.
Page 1 of 3