Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 162 for “"lipid peroxidation"”.
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
… human and mouse models. In macrophages, chronic lipid exposure promotes pro-inflammatory polarization and the activation of pyroptosis via the NLRP3 inflammasome. While the role of the canonical pyroptosis pathway has been studied in NAFLD, the role of the newly discovered noncanonical …
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Free Radical Activity, Lipid Peroxidation and Antioxidant Status in Diabetes Mellitus
… accelerated atherosclerosis. Increased levels of lipid peroxides and diminished antioxidant vitamin status have been reported in diabetic patients and are also implicated in the chronic complications of diabetes. The autoxidation and glycoxidation reactions of glucose are sources of free radicals …
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Measurement of lipid peroxidation in biology models using gas-chromatography-aass spectrometry
… (GC-TOFMS) and were found to include the lipid peroxidation product hexanal. The pro-oxidant cumene hydroperoxide elevated the levels of these lipid peroxidation products, whereas the anti-oxidant butylated hydroxy toluene (BHT) impaired their production. Derivatization of the aldehyde …
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Stimulation of lipid peroxidation by dihydroxyfumarate: The action of antioxidants and the role of free radicals
For abstract see full text.
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Reactive Oxygen Species and Lipid Peroxidation Products Contribute to Neuropathic Pain in Chronic Spinal Cord Injured Rats
… neurons in rats. Compounds that reduce ROS and lipid peroxidation are able to reduce measures of chronic neuropathic pain. Mechanical allodynia was reduced in chronic SCI rats with the intrathecal administration of Apocynin, 4-OXO-TEMPO, Tirilazad, and U-83836E. Apocynin was used to further …
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Studies on polyunsaturated fatty acid content and lipid peroxidation in preterm infant nutrition from non-maternal sources.
… Furthermore, LCPUFAs are highly susceptible to lipid peroxidation, giving rise to potentially harmful lipid peroxidation products (LPPs), which are related to major preterm morbidities. Donor human milk (DHM) and preterm formula milk (FM) are used when maternal breast milk is not available, …
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Neurobiological Substrates of Age-Associated Decline in Neuronal Excitability - Lipid Peroxidation-Dependent Modulation of Transient Potassium Current Inactivation?
… and seek to implicate oxidative stress and lipid peroxidation with the aging process in these neurons.
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Effects of Citrullus lanatus seed (Egusi) protein isolate on lipid peroxidation in malnourished rat fed on high fat diets
… serum enzymes (ALP, AST, ALT, GGT, LDH), serum lipid (cholesterol, TAG), haematological parameter (WBC, RBC, Hb, PCV, MCV, MCH, MCHC, RDW, Platelets, Neutrophils, Monocytes, Lymphocytes, LUC, Eosinophils, Basophils), and the histology of the liver and kidney. It is concluded that egusi protein …
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The Acute Effects of Nut Ingestion on Plasma Levels of Polyphenol Compounds, Biomarkers of Antioxidant Status, and Lipid Peroxidation
… phenol content, antioxidant capacity and plasma lipid peroxidation. Thirteen subjects participated in the crossover design study. After an overnight fast, walnut, almond and a control diet, in form of smoothies, were consumed by the study subjects. Each subject participated on three occasions one …
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Efficacy of tamoxifen and thymoquinone on tumor development, lipid peroxidation, and total antioxidant capacity in DMBA induced mammary carcinoma in female Sprague-Dawley rats
… due to overproduction of free radicals and lipid peroxidation. Thymoquinone (TQ), from Nigella sativa seeds, is a Middle East natural medicine and it has been used to treat a number of diseases, including cancer. The aim of my study was to investigate the effect of TQ and TAM on tumor …
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Synthesis, biological activity and mechanism of atypical carotenoid antilipoperoxidants
Lipid peroxidation has long been correlated to and proposed to be a causative factor in a myriad of human diseases. However, identifying a causative mechanistic role of lipid peroxidation has proven challenging and the role of oxidized lipids in disease pathogenesis remains enigmatic. We posited …
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Development of methodology for the use of multi-bed sorbent traps with gas chromatography time of flight mass spectrometry
<p>The lipid peroxidation of unsaturated fatty acids in cellular membranes leads to the formation of alkanes, aldehydes, alkanals, alk-2-enals, and hydroxyl alkenals. The free radicals formed during the process of lipid peroxidation can react with and damage cellular components. Lipid peroxidation …
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Examining the Impact of PUFAs and the Role of Autophagy in Iron-Induced Ferroptotic Cell Death
… iron-dependent non-apoptotic cell death involves lipid peroxidation and associates with cardiometabolic disease and cancer. I established a model of iron overload in L6 cells and measured cell viability, toxicity and lipid peroxidation. Importantly, in PUFA pre-treated cells, the susceptibility to …
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Modular synthesis-enabled mechanistic characterization of the potent antilipoperoxidant activity of peridinin
The peroxidation of polyunsaturated fatty acids is a hallmark of many human disorders, yet is has often remained ambiguous whether lipid peroxidation plays a causative and therefore addressable role in the onset or pathogenesis of a disease. Small molecule inhibitors of this oxidative process in …
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Mechanistic Studies of Lipoxygenases Using Synthetic Substrate Analogues
Lipid peroxidation plays a key role in the biochemistry of living systems. The oxidation of polyunsaturated fatty acids is crucial in pain and inflammation mediation, as well as in cardiovascular, gastrointestinal and reproductive function modulation. However, if excessively stimulated, this …
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Altering Nitric Oxide Bioavailability and Lipid Profiles in Endothelial Cells By Polycyclic Aromatic Hydrocarbons in Particulate Matter
… are well known to induce oxidative stress and lipid peroxidation via generation of reactive oxygen species (ROS). Lipid peroxidation involves regulating endothelial nitric oxide synthase via inhibition of its activity, and as a result, mediates dilation of coronary arterioles is involved with …
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Oxidative stress and seed survival
… were metabolically active, contained products of lipid peroxidation, displayed low levels of enzymatic protection against activated oxygen and peroxides, and a two-peak free radical EPR signal. During fully hydrated storage at 16 °C for up to 18 months, seeds exhibited, sequentially, an increase …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… of the most reactive aldehydes produced during lipid peroxidation (LPO) and has been demonstrated to have cytotoxic and genotoxic effects. Several oxidoreductases (ORs) have been reported to detoxify HNE including aldehyde dehydrogenase (ALDH) and aldo-keto reductases (AKRs). Glutathione …
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Exercise and free radical induced damage to human skeletal muscle
… compromise muscle antioxidant status or elevate lipid peroxidation indices 4 days and 7 days after exercise, suggesting free radicals did not contribute to muscle damage at these times. In the previous study functional measures were not collected in the days following exercise and biochemical …
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The db mouse as a model for steatohepatitis
… associations with obesity, diabetes and dyslipidaemia. Overlapping pathological mechanisms may be involved. The course of the disease will remain unpredictable, and specific treatment will only be able to be instituted once the pathogenesis is fully understood. This thesis reviews current …
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