Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"lipid packing"”.
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Influence Of Cholesterol And Bilayer Asymmetry On Membrane Protein Distribution In Polymer-Tethered Raft-Mimicking Lipid Membranes
<p>It is now widely recognized that lipid rafts, which are membrane domains enriched in cholesterol (CHOL) and sphingolipids (SL), play a significant functional role in the plasma membrane. Raft domains particularly affect membrane functionality by causing sequestering of membrane proteins. …
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Lipid Composition and Configuration Drive Biophysical Properties of The Mammalian Plasma Membrane
<p>In the 1970s, it was established that phospholipid (PL) classes are asymmetrically distributed across the (PM) leaflets. Recapitulating strategies coupled with newly developed, high-resolution shotgun lipidomics, our lab confirmed PL class asymmetry and surprisingly measured the endoplasmic …
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Light-induced transformations in biomembranes
… the application of the F-azo to multicomponent lipid membranes, which exhibit a coexistence of domains in different liquid phases due to a miscibility gap between the lipids. We perform initial experiments to investigate whether F-azo can be employed to modulate the lateral lipid packing and …
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DECIPHERING THE MOLECULAR MECHANISM BEHIND THE SARS-COV-2 FUSION DOMAIN
… to the late endosomal membrane, with both pH and lipid composition significantly impacting fusion. It was found that the endosomal resident anionic lipid BMP imparts a negative impact on lipid packing within the membrane, which positively correlates with fusion. The unique mechanism by which the …
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A Physicochemical and Biophysical Investigation into the Role of Lysyl- Phosphatidylglycerol in the Membrane of Staphylococcus aureus under mild acidic conditions
… and CAMPs remain under-investigated, due to the lipid’s lability in mild aqueous conditions. This study examines the role of L-PG in responses to epithelial defences and describes the synthesis and characterisation of a stable L-PG analogue designed for use in biophysical experiments to …
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Pct1 regulates phosphatidylcholine synthesis in response to changes in surface curvature elastic stress sensed on the inner nuclear membrane
… membranes consist of a complex mixture of phospholipids that determine their size, shape, and function. Among the distinct types of phospholipids found in membranes of living organisms, phosphatidylcholine (PC) is the most abundant. The rate-limiting step of the predominant pathway for PC …
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Relating phase separation and thickness mismatch in model lipid membranes.
Membrane lipids can spontaneously undergo a process called phase separation wherein they organize into domains with different compositions. Phase separation has been proposed as a mechanism in the formation of heterogeneous lipid regions (e.g. rafts) in cell membranes. The activity and partitioning …