Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"lipid monolayer"”.
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Mechanism of C -Cadherin Binding: Multiple Adhesive Alignments and a Multi-Stage Unbinding Trajectory
… the structure of membrane supported C-cadherin monolayers, that are used in the surface force measurements, is presented in the latter part of the thesis. Using ellipsometry, we monitor the binding of C-cadherin to lipid monolayers in real time. These data suggest that in the presence of …
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Study of Phospholipid/Graphene interfaces and the effect of substrate curvature on lipid morphology and dynamics.
Phospholipids are an important class of lipids which are widely used as model platforms to study biological processes and interactions. They have been known to form stable interfaces with solid substrates like graphene, and these interfaces have potential applications in bio-sensing and targeted …
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Surface tension and electroporation of lipid bilayers
Electroporation of lipid bilayers is widely used in DNA transfection, gene therapy, and targeted drug delivery and has potential applications in water desalination and filtration. A better, more thorough molecular understanding is needed, however, before such devices can be effectively used and …
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Biochemical and structural studies of the FtsZ:FtsA complex and polymerising abilities of the FtsA protein
… was observed when FtsA was polymerised using a lipid monolayer surface and FtsAs from three organisms formed polymers in cells when overexpressed, as observed by electron cryo-tomography. Mutants that disrupt polymerisation also showed a significant cell division phenotype in a temperature …
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How to Mend a Broken Heart: Massive Endocytosis and the Role of Lipidic Forces in Membrane Trafficking
… are related to perturbations within the outer lipid monolayer of the plasmalemma or through coupled calcium-mediated fusion and phosphatidylinositol 4,5-bisphosphate (PIP2) signaling. Both forms of MEND do not rely on classical endocytic proteins such as clathrin or dynamin and appear …
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Development of new tools to study drug-lipid interactions and their application to investigating amphotericin b's association with model cell membranes
… cell membrane systems were used: sterol-free lipid monolayers adsorbed to a Hg electrode and sterol-free or sterol-containing floating lipid monolayers on a Langmuir trough. Electrochemical control over the adsorbed monolayer allowed the defectiveness of the layer to be varied and the …
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Adjuvant Interactions with Lipid Membranes and Their Effect on Cellular Immune Responses
… membrane. Although few have considered how lipid-mediated interactions contribute to adjuvanticity, previous studies suggested aluminum-based adjuvants (ABAs) have high affinity for sphingomyelin and cholesterol, which allowed them to activate dendritic cells exclusively through lipid …
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Experimental Measurement of the Utricle's Dynamic Response and the Mechanoelectrical Characterization of a Micron-Sized DIB
… is a droplet interface bilayer (DIB). A DIB is a lipid bilayer that is formed when the interface of two aqueous droplets, that contain free-floating lipids, are joined. The aqueous droplets are suspended in a nonpolar environment (oil) and the oil/water interface forms a lipid monolayer. This …
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Investigation into the lipid activation of calpain and its role in cataract formation
… appears to be investigate the mechanism of lipid activation of calpains as an essential link towards understanding the molecular and cellular dynamics of cataractogenesis in vivo. A clear picture of the enzymatic events in cataractogenesis will form the basis of drug development to cause …
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Revealing Molecular Adversaries of Human Health Using Advanced Imaging Technology
… with integrated wells and decorated with a lipid monolayer to capture and image BRCA1 complexes. This imaging platform minimizes heterogeneity and ensures the sample quality while not biasing confirmation. Thus, allowing for high resolution cryo-EM imaging of flexible native proteins. We …
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Investigation into the structure function relationship of the membrane interaction of amphiphilic alpha helical antimicrobial peptides
… aureus and Gram-negative Escherichia coli. Monolayer studies using lipid extract from these target organisms and parallel studies using mimetic monolayers confirmed a high level of peptide membrane interaction. The single lipid monolayer results suggested that VPI and BYDV-MP have a lower …
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Wechselwirkung zwischen Lipiden und DNA : auf dem Weg zum künstlichen Virus
… Polyelektrolytenhohlkugel bildet, die mit einer Lipiddoppelschicht bedeckt ist. Um intakte Doppelschichten zu erzeugen, muss die Wechselwirkung zwischen Lipid und Polyelektrolyt (z.B. DNA) verstanden und optimiert werden. Dazu ist es notwendig, die strukturelle Grundlage der Interaktion …