Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"lipid microdomains"”.
-
Probing the formation of mammalian cell lipid microdomains with nanometer-scale imaging secondary ion mass spectrometry
… a more heterogenous environment of proteins and lipids. The complexity of living cells have made for difficulties in obtaining a complete understanding of the plasma membrane, especially that of the sphingolipids’ organization. The recent application of imaging mass spectrometry to biological …
-
Functional in vitro analyses of lipid raft-associated cathepsin b: implication for the invasive phenotype of inflammatory breast cancer
<p>FUNCTIONAL IN VITRO ANALYSES OF LIPID RAFT-ASSOCIATED CATHEPSIN B: IMPLICATION FOR THE INVASIVE PHENOTYPE </p> <p>OF INFLAMMATORY BREAST CANCER</p> <p>by</p> <p>BERNADETTE C. VICTOR</p> <p>December 2011</p> <p>Advisor: Dr. Bonnie F. Sloane</p> <p>Major: Cancer Biology </p> <p>Degree: Doctor of …
-
SOTTODOMINI DEL RETICOLO ENDOPLASMATICO IN FISIOLOGIA E PATOLOGIA
… in physiology, I focused on a possible role of lipid microdomains in the segregation and plasma membrane transport of membrane proteins. As models for my study I used an endoplasmic reticulum resident protein, cytochrome b5, and an its variant, b5-22, different from the wild-type protein only …
-
Intracellular Trafficking of Influenza Hemagglutinin and Members of the Low Density Lipoprotein Receptor Family
… by a mechanism mediated by an association with lipid microdomains known as lipid rafts. Lipid rafts and their associated proteins are operationally defined by their resistance to detergent solubilization at cold temperatures. By systematic mutagenesis of the transmembrane domain of …
-
Dynamical models, chemo-mechanical coupling and numerical recipes for some soft biological systems
… events and structural re-organization, in which lipids order transitions and their micro-mechanical interplay with transmembrane proteins induce membrane conformational changes. It is reasonable to assume the lipid membrane as a visco-hyperelastic body that exhibit both in-plane fluidity and …
-
Toca-1 driven actin polymerisation at membranes
… of filopodia-like structures (FLS) on supported lipid bilayers, Toca-1 is recruited early, suggesting a Toca-1 scaffolding mechanism could precede the recruitment of other actin regulators. One prediction of this model is that Toca-1 would bind proteins previously implicated in filopodia …
-
Costimulatory function of CD44
… these kinases were redistributed into so called lipid rafts. It is supposed that for T cell activation a relocation of the TCR/CD3 complex into the same membrane microdomains is required. The data are interpreted in the sense that the costimulatory function of CD44 relies on its cooperativity …
-
Protein-lipid interactions in raft-exhibiting membranes probed by combined AFM and FCS
… far from being an inert assembly of protein and lipids which separates cells from the surrounding environment. A multitude of biological processes, ranging from active transport of ions into and out of the cell, to the immune response, are regulated at the level of the plasma membrane. The …