Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 92 for “"lipid droplets"”.
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Structural evolution of lipid droplets in murine liver cancer
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Femtosecond CARS Microscopy to characterize lipid droplets in Engineered Adipose Tissue
… for fat and releasing energy in form of lipids. Different classes of fatty acids, such as saturated and unsaturated have different biological effects on adipocytes. Lipid droplets are the primary organelles in adipocytes that store these fatty acids in form of lipids, and the development …
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Metabolic Regulation at Sub-Organelle Length Scales: Inter-Organelle Contacts and Lipid Droplets
Page xii is misnumbered as page xi.
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Intestinal cytoplasmic lipid droplets, associated proteins, and the regulation of dietary fat absorption
… to energy balance, and regulates blood lipid concentrations. These functions are important to health, but can also become dysregulated and contribute to diseases such as obesity, diabetes, and cardiovascular disease. The small intestine absorbs dietary fat through an efficient multi step …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
… and also co-localised and aggregated lipid droplets. Many viruses such as hepatitis C virus (HCV) and Dengue virus recruit lipid droplets to replication complexes. We found that lipid droplets became larger in HPeV-infected cells, but do not co-localise with replication complexes. To …
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PNPLA3 P.I148M VARIANT INCREASES LIPID DROPLETS NUMBER AND SIZE IN PATIENT-DERIVED LIVER ORGANOIDS
… human liver organoids (HLOs) and studied lipid accumulation across different PNPLA3 genotypes. HLOs were differentiated toward a hepatocyte-like phenotype (Hep-HLO) and exposed to 300 μM Palmitic and Oleic fatty acids (FAs) for 72h. Lipid droplets (LDs) average size and number (normalized …
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TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
… Laboratorien zeigten jedoch, dass TIP47 ein Lipid-Tröpfchen-assoziiertes Protein ist, wobei seine genaue Funktion auf den Lipid-Tröpfchen bislang unbekannt blieb. Unter Verwendung eines RNAi-Ansatzes konnten wir zeigen, dass ein Verlust der TIP47-Expression keinen Effekt auf den MPR-Transport …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid content and responsiveness to …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… non-alcoholic fatty liver disease (NAFLD) and lipid-droplet-filled hepatocytes can develop cancer in non-cirrhotic, relatively soft tissue. Given the clear association between mechanical stress and cancer development in cirrhosis, we hypothesized that lipid droplet accumulation in NAFLD is a …
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Micro lipid droplet precursors of milk lipid globules
The lipid in milk (milk fat) is found in the form of droplets known as milk lipid globules (MLG). These milk lipid globules are encompassed by a unit membrane known as the milk lipid globule membrane (MLGM) which is derived from the apical plasma membrane of the mammary epithelial cell during …
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Elucidating the Role of Yeast Lipin (PAH1) in Lipid Droplet Biogenesis
Lipid droplets are unique organelles important for a host of cellular functions including the storage of neutral lipids, but factors that regulate the biogenesis and maintenance of these organelles remain relatively unknown. The primary focus of this dissertation will be to understand the role of …
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Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages
… atherosclerosis, macrophages become filled with lipid droplets and form fatty plaques in artery walls. The formation of these atherosclerotic plaques is dependent on the macrophage growth factor colony stimulating factor-1 (CSF-1); however, understanding the changes in CSF-1 signaling and related …
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Dissecting the Role of the Lipodystrophy Protein Seipin in the Biogenesis of the Lipid Droplet Organelle
… to be little more than inert storage depots, lipid droplets have recently become recognized as unique, dynamic, regulated organelles that play an essential role in fat storage. Despite this increased interest, much remains unknown. Lipid droplets have been observed to emerge from the …
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Steroid Hormone Regulation of Implantation
… of aromatase in the process of decidualization. Lipid droplets in various organs are indicative of steroidogenic potential. Previous studies have shown occurrence of lipid droplets in the uterus during pregnancy. In chapter III we describe how P mediates the assembly of these lipid droplets at …
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Changes in mitochondrial PLIN3 and PLIN5 protein content in rat skeletal muscle following acute contraction and endurance training
Surrounding lipid droplets in skeletal muscle are the perilipin (PLIN2-5) family of proteins, regulating lipid droplet metabolism. During exercise lipid droplets provide fatty acids to the mitochondria for oxidation while increasing their proximity to each other. Whether PLIN3 and PLIN5 associate …
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MICROGLIA-SUFFICIENT BRAIN ORGANOID
… We showed that the iMacs contain a high level of lipid droplets and modulate the metabolism, proliferation and axon development of neuronal progenitor cell (NPC) in the organoids. The lipid droplets-loaded macrophages were also observed in mouse and human embryonic brain. Microglia-sufficient …
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Functional roles of butyrophilin 1a1 and xanthine oxidoreductase in lactating mammary gland
… and are secreted into milk in association with lipid droplets. Disruption of either the BTN or XOR gene in mice causes the accumulation of large pools of lipid in the cytoplasm, thus suggesting that both proteins may function in the accretion and/or secretion of milk-lipid droplets during …
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Antioxidant system remodeling underlies off-target effects of anti BCMA-Targeted Immunotherapy in Multiple Myeloma [Il rimodellamento del sistema antiossidante è alla base degli effetti off-target dell’immunoterapia anti-BCMA nel Mieloma Multiplo]
… adottato un approccio integrato proteomico, lipidomico e funzionale per definire i determinanti molecolari della risposta cellulare a BeMa. L’analisi proteomica del siero di donatori sani e pazienti con MM ha evidenziato una significativa sovraespressione di apolipoproteine implicate nel …
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Algae and cyanobacteria platforms for engineering biofuel production
… triggers were used to redirect carbon into lipid biosynthesis. Wild-type and starch mutants of Chlamydomonas reinhardtii, a well-established model green alga, were subjected to nitrogen starvation to examine carbon storage and partitioning between starch and lipid synthesis. The starch-less …
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