Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"lipid droplet"”.
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Micro lipid droplet precursors of milk lipid globules
The lipid in milk (milk fat) is found in the form of droplets known as milk lipid globules (MLG). These milk lipid globules are encompassed by a unit membrane known as the milk lipid globule membrane (MLGM) which is derived from the apical plasma membrane of the mammary epithelial cell during …
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Elucidating the Role of Yeast Lipin (PAH1) in Lipid Droplet Biogenesis
Lipid droplets are unique organelles important for a host of cellular functions including the storage of neutral lipids, but factors that regulate the biogenesis and maintenance of these organelles remain relatively unknown. The primary focus of this dissertation will be to understand the role of …
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Dissecting the Role of the Lipodystrophy Protein Seipin in the Biogenesis of the Lipid Droplet Organelle
… to be little more than inert storage depots, lipid droplets have recently become recognized as unique, dynamic, regulated organelles that play an essential role in fat storage. Despite this increased interest, much remains unknown. Lipid droplets have been observed to emerge from the …
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Molecular Dissection of Bsc2: A Novel Negative Regulator of Triglyceride Lipolysis for a Lipid Droplet Subpopulation
Eukaryotic cells store lipids in the form of triglyceride (TG) and sterol-ester (SE) in cytoplasmic organelles called lipid droplets (LDs). Distinct pools of LDs with unique surface proteomes exist in cells, but a pervasive question is how proteins localize to and convey functions to specific LD …
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DEFINING THE ROLE OF LIPID DROPLET SCAFFOLDING PROTEINS IN HEPATIC STEATOSIS INDUCED BY HEPATITIS C VIRUS CORE PROTEIN
Hepatitis C Virus (HCV) is an enveloped RNA virus responsible for 170
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Characterization of the first steryl ester transporter in biology, Yol075c, and its pleiotropic effects
… occurs through a transport pathway linking the lipid droplet (LD) stored steryl esters and mediated by the ABC transporter Yol075c. Sterols are synthesized in the ER and are bound for one of two fates, either free or esterified. Sterols being metabolically expensive to produce and toxic in high …
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Protein quality control in the mammalian endoplasmic reticulum
… poly-ubiquitylation. AUPI is also necessary for lipid droplet formation. Lipid droplets are cytoplasmic organelles that store neutral lipids. Based on the data that AUPI depletion affects both ER quality control and lipid droplet formation and that pharmacological inhibition of lipid droplet …
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Changes in mitochondrial PLIN3 and PLIN5 protein content in rat skeletal muscle following acute contraction and endurance training
Surrounding lipid droplets in skeletal muscle are the perilipin (PLIN2-5) family of proteins, regulating lipid droplet metabolism. During exercise lipid droplets provide fatty acids to the mitochondria for oxidation while increasing their proximity to each other. Whether PLIN3 and PLIN5 associate …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
… and also co-localised and aggregated lipid droplets. Many viruses such as hepatitis C virus (HCV) and Dengue virus recruit lipid droplets to replication complexes. We found that lipid droplets became larger in HPeV-infected cells, but do not co-localise with replication complexes. To …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… altered subcellular localization and disrupted lipid droplet biogenesis. Screening of a DGAT2 lysine-to-arginine mutant library demonstrated that several lysine residues are involved in regulating DGAT2 stability. Substitution of two lysine clusters was sufficient to mislocalize DGAT2 and …
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Histology of bovine mammary tissue during advanced stages of induced lactation
… between days 18 thru 23. On day 18 small lipid droplet epithelia predominated but was replaced with mixed lipid droplet epithelia by day 23. Day 18 epithelia had elongated dark staining nuclei. Epithelia on day 23 had spherically shaped nuclei containing several nucleoli and a decreased …
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Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid content and responsiveness to …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… non-alcoholic fatty liver disease (NAFLD) and lipid-droplet-filled hepatocytes can develop cancer in non-cirrhotic, relatively soft tissue. Given the clear association between mechanical stress and cancer development in cirrhosis, we hypothesized that lipid droplet accumulation in NAFLD is a …
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Integrative Multivariate Analysis of Mouse Liver Acini
… the spatial positioning of hepatocytes and lipid droplets, mitochondria, and fibrotic structures. Additionally, it sought to identify phenotypic identities that regulate mitochondria, lipid droplet, and fibrotic activity in different regions of the liver. A unique methodology where live …
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Autophagy in the developing Drosophila brain
… I investigated the importance of autophagy to lipid droplet formation and protein turnover in the neural stem cells, neurons, and glia of the larval Drosophila brain. The role of the endomembrane system in autophagy in neurons and neural stem cells was also considered, as was the movement of …
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FoxO1 in the regulation of adipocyte autophagy and biology
… regulated adipocyte biology: (1) to control lipid droplet growth via fat specific protein 27 (FSP27) in adipocytes; and (2) to differentially regulate mitochondrial uncoupling proteins (UCP) that have been implicated in browning of white adipose tissue and redox homeostasis. Mechanistically, …
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Hepatic gene networks due to the trans-10, cis-12-conjugated linoleic acid supplementation in growing male mice
… transcription regulators and transporters in lipid metabolism. Feeding growing male mice diets supplemented with 0.3% trans-10, cis-12-CLA for 6 weeks significantly increased the expression of hepatic genes involved in fatty acid uptake (Cd36), TG synthesis (Acaca, Gpam and Scd), lipid droplet …
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Femtosecond CARS Microscopy to characterize lipid droplets in Engineered Adipose Tissue
… for fat and releasing energy in form of lipids. Different classes of fatty acids, such as saturated and unsaturated have different biological effects on adipocytes. Lipid droplets are the primary organelles in adipocytes that store these fatty acids in form of lipids, and the development …
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Functional roles of butyrophilin 1a1 and xanthine oxidoreductase in lactating mammary gland
… and are secreted into milk in association with lipid droplets. Disruption of either the BTN or XOR gene in mice causes the accumulation of large pools of lipid in the cytoplasm, thus suggesting that both proteins may function in the accretion and/or secretion of milk-lipid droplets during …
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