Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"lipid accumulation"”.
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Lipid accumulation and utilization during microcycle growth of Aspergillus niger.
… taken to attempt to minimize such problems. The lipid content and composition was investigated throughout the microcycle by the use of column and thin layer chromatography and by gas-liquid chromatography. The major classes of neutral lipid were triacyl glycerols, fatty acids, sterols and sterol …
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Effect of UV-A irradiance on lipid accumulation in Nannochloropsis oculata
… and can accumulate a considerable amount of lipids. Their lipids can be grouped into two categories, storage lipids, which are mainly triglycerides (TGs), and structural lipids, which are composed of polyunsaturated fatty acids (PUFAs). PUFAs are essential nutrients for both aquatic animals …
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The biochemistry of lipid accumulation in Mucor circinelloides and Mortierella alpina
1. The profile and biochemistry of growth and lipid accumulation in M. circinelloides and Mt. alpina were investigated. 2. A nitrogen-limited condition was vital in triggering lipid accumulation in both fungi, which was in agreement with previous work reported in oleaginous yeasts (Botham and …
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Energy substrates, metabolic regulators, and lipid accumulation during culture of in vitro-produced bovine embryos
… blastocyst production per oocyte and decreased lipid content in bovine embryos. The use of phenazine ethosulphate (PES) or fetal calf serum (FCS) supplementation did not affect embryonic development; however, PES consistently decreased, and FCS increased lipid content of embryos compared to the …
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High fat diet causes hepatic lipid accumulation by programming lipid synthesizing genes via gene body methylation
… diet (HFD) has been shown to cause more hepatic lipid accumulation as compared to a low-fat control (C) diet. However, it is still unclear what role epigenetic mechanisms play in hepatic lipid accumulation. We hypothesize that a HFD will cause greater hepatic lipid accumulation through increased …
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TEMPOL and Insulin Resistance: A study of the underlying mechanisms behind changes in glucose metabolism, lipid accumulation and cellular stress
… TEMPOL treatment reduced body mass, improved lipid metabolism, decreased adipogenesis, reduced inflammation and oxidative stress, and improved insulin sensitivity in high-fat diet-fed mice. In vitro studies delineated underlying cellular mechanisms showing TEMPOL protected against …
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A decrease in dkk1, a Wnt inhibitor, contributes to placental and fetal lipid accumulation in an obesity-prone rat model
Made available in DSpace on 2011-05-25T15:06:43Z (GMT). No. of bitstreams: 6 Appendix B-qRT-PCR Curves.pdf: 4421573 bytes, checksum: e9ba82137f083fa9f50680e7baf8c92c (MD5) Appendix A-Rodent Obesity Models.pdf: 102817 bytes, checksum: d22fc8b17473156234c55d696e75cadd (MD5) Strakovsky_Rita.pdf: …
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Effect of yerba mate tea caffeine and green coffee by-products on in vitro adipogenesis and lipid accumulation and their incorporation into functional beverages
… has been also associated with suppressing lipid accumulation and weight gain, making the well established energy drink market an ideal avenue to expand product health functionality. The objective of this study was to evaluate the effect of caffeine extracted from Yerba mate (Ilex …
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Investigating the regulation of tumour associated lipogenesis using the model organism, Saccharomyces cerevisiae
… evidence that the HOG pathway is involved in lipid accumulation, which occurs in nitrogen depleted cells as they enter stationary phase. Understanding this lipogenic switch is important both for the biotechnology industry (for example biofuels) and understanding human disease, where cancer …
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Mechanisms into the development of fatty liver disease: role of bile acids, Betaine and MHY908
… μM - 300 μM for 24 h, 48 h and 72 h after which lipid accumulation, cell toxicity, oxidative stress and mitochondrial function were assessed. Further investigations were employed with bile acids chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA), betaine and MHY908 to determine whether …
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Phyisiological, genomic and metabolic characterization of the oleaginous yeast Papiliotrema laurentii UFV-1
… yeast Papiliotrema laurentii UFV-1 presented the lipids in the culture media with glucose and xylose as carbon sources. Unlike most oleaginous yeasts, lipid accumulation by P. laurentii UFV-1 begins at the exponential growth phase, presentin a lipid accumulation growth associated. Furthermore, …
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USE OF MICROALGAE FOR WASTEWATER TREATMENT AND BIOFUEL PRODUCTION: EFFECTS OF ENVIRONMENTAL CONTAMINANTS ON THE CELLULAR RESPONSE
… to be converted into biodiesel depends on the accumulation of lipids, mainly triacylglycerols. However, the presence of toxic contaminants in municipal or industrial wastewater could negatively affect the biomass growth and modify the pattern of lipid accumulation in algae cells. This research …
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Peripartal Lipid Metabolism and Tissue Fatty Acid Composition in Holstein Cows Fed Supplemental Fat During the Dry Period
Our laboratory showed marked decreases in hepatic lipid accumulation at calving after attempting to add BCS by feeding fat to dry cows. Results were confounded; feeding supplemental fat to dry cows was associated with lower DMI and BCS loss. Consequently, 36 cows were fed high-grain or …
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Suppression of pro-inflammatory signalling pathways by sulforaphane
… vitro model, investigating the effect of SF on lipid accumulation within adipocytes and adipose tissue inflammation in response to macrophage-conditioned medium (MaCM) using human SGBS adipocytes. SF at 10μM significantly reduced levels of lipid accumulation within adipocytes and increased the …
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Investigation of Microbiome Metabolites and Mitochondrial Function in a model of Non-Alcoholic Fatty Liver Disease
… that these metabolites contribute to lipid deposition in the liver by altering hepatic mitochondrial function, we assessed how TMAO and PAA affect hepatocyte bioenergetics in cell models of liver steatosis. Proliferative and differentiated HepaRG cells were cultured under standard …
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Utilising Yeast as a Model Organism to Deconstruct the Regulation of Tumour Associated Lipogenesis
… a better understanding of tumour associated lipid formation may offer targets for the development of new therapies. Yeast is frequently used as a paradimic organism for the study of human diseases. In this study a Nile red assay has been developed, optimised and validated to measure levels of …
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Autophagy: activation, function and regulation by a protein restricted diet during pregnancy and lactation
… LP diet stimulates autophagy and hepatic lipid accumulation, and decreases expression of histone deacetylase-3 (Hdac3) in the liver of rat dams. Histone acetylation is associated with increased gene transcription. Specifically, it has been reported that HDAC3 inhibition induces LC3B …
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Mechanisms into the development of fatty liver disease: role of free fatty acids and alcohol
… alcohol (100 mM) for 24, 48 and 72 h after which lipid accumulation and cell toxicity was assessed. Subsequent studies at 24 hr examined oxidative stress, mitochondrial function and lipogenic proteins. Results: PA treatment showed a detrimental effect on cell viability and lipid accumulation than …
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