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Showing 1 to 20 of 648 for “"linker"”.

  1. Charakterisierung des Kerntransportsystems von Linker-Histonen

    Baeuerle, Marc2012

    … Kern des Nucleosoms. Die Nucleosomen sind über Linker-DNA miteinander verbunden, an der Ein- und Austrittsstelle der DNA-Doppelhelix an den nucleosomalen Core-Partikeln ist ausserdem ein H1-Histon ( Linker-Histon ) assoziiert. Von H1-Histonen sind 7 Subtypen (H1.1-H1.5, H1t und H1°) bekannt, von …

    goettingen Repository record

  2. An extensible dynamic linker for C++

    Vemulapati, Murali KrishnaMassachusetts Institute of Technology1995

    Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1995.

    mit Repository record

  3. Langmuir Monolayers of Minimal-linker Dimeric Surfactants

    Singh, Srikant KumarUniversity of Saskatchewan2024

    … synthetic approach, have the shortest possible linker joining the two head-groups. Thus, these compounds are referred to as "minimal linker" compounds. The combination of a compact head-group and custom tail-chain length leads to a family of compounds that are unique amongst gemini surfactants. …

    sask Repository record

  4. Linker-based Lecithin Microemulsions as Transdermal Drug Delivery Systems

    Yuan, Shuhong Jessica2010

    … solvents” were formulated with lecithin and linker molecules. The main objective of this dissertation was to test this concept of linker-based lecithin microemulsions in transdermal delivery. In the first part of this study, linker-based lecithin formulations were developed using soybean …

    toronto-retro Repository record

  5. CRAMP1 drives linker histone expression to enable Polycomb repression

    Matthews, RachaelUniversity of Cambridge2025

    … for decades, but the function of the linker histone (H1) remains enigmatic. H1 compacts nucleosome arrays in vitro, but the multiple H1 subtypes and variants encoded in mammalian genomes (11 in mice and humans) hamper genetic studies to determine H1 function in vivo. Challenging the …

    cambridge Repository record

  6. Linker Histone Medicated Regulation of Mitotic Chromosome Compaction and Individualization

    Choppakatla, Pavan

    … a mystery. Here, I investigated the role of the linker histone variant H1.8 in regulating mitotic chromosome structure. I showed that H1.8 suppresses binding of condensins and topo II to mitotic chromatin in Xenopus egg extracts. Using an in vitro reconstitution system, I showed that H1.8 …

    rockefeller Repository record

  7. Structural and biochemical studies of the yeast linker histone, Hho1p

    Osmotherly, Lara MayUniversity of Cambridge2010

    … around an octamer of core histone proteins. Linker histones bind through their globular domain at the nucleosome dyad and to internucleosomal DNA through their C-terminal basic tail. The Saccharomyces cerevisiae linker histone homologue, Hho1p, contains two domains, GI and GII, that have …

    cambridge Repository record

  8. The role of linker histone variant in double strand break repair

    Arbon, Darren DUniversity of Birmingham2010

    … to access the DNA. It has been shown that linker histone variants inhibit the double strand break (DSB) repair pathway known as non-homologous end joining (NHEJ). NHEJ, in vivo, requires the KU complex, the DNA dependent protein kinase (DNA-PK) and the DNA ligase IV/XRCC4 (LX) complex. In …

    birmingham Repository record

  9. The synthesis of WAY-derivatives to find linker location and a new linker to attach a fluorescence tag for homo- or hetero-dimer of 5-HT receptor ligands

    Kim, Soo Jeong 1984-University of Houston2014

    … or hetero dimeric ligands. In addition, a new linker for homodimers of M100907 derivatives has been developed. Through this new linker, a fluorescence tag can be attached to the dimeric ligands. This will be used to both probe the activity of receptor dimers as well as visualize them.

    houston Repository record

  10. Regulation of Chromatin Multi-Scale Organization and Function by Linker Histone H1

    Duba, Irene2026

    … One factor that appears to play a key role is linker histone H1, which is the most prevalent chromatin-binding protein in the cell. It has long been thought to be responsible for compacting chromatin and repressing transcription, though many historical studies of H1 were performed in vitro, and …

    rockefeller Repository record

  11. FUNCTIONAL EFFECT OF ALTERATIONS TO E. coli METHIONYL-tRNA SYNTHETASE BETA-LINKER LENGTH

    Xia, YiyuanWake Forest University2015

    Aminoacyl-tRNA synthetases (AARSs) are essential enzymes that catalyze the

    wfu Repository record

  12. Oligodeoxynucleotide synthesis using protecting groups and a linker cleavable under non-nucleophilic conditions

    Lin, Xi

    mtu Repository record

  13. Determination of the trajectory of linker DNA by fluorescence energy transfer distance measurements

    Scherl, Dale S.University of Illinois at Urbana-Champaign2011

    … distance measurements to study the trajectory of linker DNA as it enters and exits the histone octamer in a nucleosome core particle. Measurement of the DNA-to-protein distances gives important structural information about the most fundamental level of chromosomal organization, and allows …

    uiuc Repository record

  14. An experimental approach to determine the binding mode of yeast linker histone, Hho1p

    Smith, Elizabeth MDepartment of Molecular and Cell Biology2003

    … to investigate of the binding mode of yeast linker histone Hholp to nucleosomes, using magnetic bead pull-down assays. To understand the structural and regulatory role of, Hholp, the linker histone in Saccharomyces cerevisiae, and that of higher eukaryotes (Thoma et al., 1979), it is …

    cape-town Repository record

  15. Pleuromutilin and its Application Towards Bidentate Antibiotics: Triazoles, Linker Chemistry, and Serendipitous Discoveries

    Breiner, Logan MichaelVirginia Tech2025

    The world is facing a global antimicrobial-resistance (AMR) crisis. Classes of antibiotics continually face ineffectiveness as resistance mechanisms in microbes develop and propagate. The semi-synthetic derivatization of natural product antibiotics has provided many of our treatments, but new …

    vt Repository record

  16. Components Required for the Death and Degradation of the Linker Cell in C. Elegans

    Kutscher, Lena Marlise

    … apoptosis. One prominent cell death program, linker cell-type death (LCD), is morphologically conserved, and independent of the key genes that drive apoptosis. Instead, LCD functions, in part, through the stressrelated protein HSF-1, and subsequent upregulation of members of the ubiquitin …

    rockefeller Repository record

  17. The Role of Linker 2 (L2) Region in RhTRIM5α Assembly and HIV-1 Restriction

    Sastri, Jayalaxmi2016

    <p>The cellular restriction factor TRIM5alpha inhibits infection by numerous retroviruses in a species specific manner. TRIM5alpha protein from rhesus macaques (rhTRIM5alpha) and a related protein TRIM-Cyp from Owl monkeys restrict infection by HIV-1 while human TRIM5&alpha; (huTRIM5alpha) …

    loyola-thes Repository record

  18. Reexamining the role of linker histones beyond 30 nm fibers in a complex chromatin environment

    Kuerzi, Amanda, author, Hansen, Jeff, advisor, Stargell, Laurie, committee member, Stasevich, Tim, committee member, Mykles, Donald, committee memberColorado State University. Libraries2024

    … the nucleosome and the basis for 10 nm fibers. Linker histones also play an important role in chromatin compaction. Previous work showed that linker histones are important for the formation of 30 nm structures. 30 nm structures were long held to be folding intermediates for repressive chromatin …

    colostate Repository record

  19. Funktionalisierte Linker für Metallorganische Gerüstverbindungen, deren postsynthetische Modifikation und polar markierte Schutzgruppen für terminale Alkine

    Roy, PascalUniversität Bielefeld

    … blocks, the inorganic node and the organic linker, makes many scientists dream of materials with very special chemical, electronic, optic and/or magnetic properties. For individual applications both building blocks, but also possibly in the framework embedded guests, play a crucial role. …

    bielefeld Repository record

  20. On the Interactions of Augmin with Microtubules and the Mechanics of the Cross-Linker PRC1

    Dottore, Alejandro

    … level with microtubules; second, the cross-linker PRC1's frictional response resisting motion between two microtubule filaments was analyzed to determine the dependence of the frictional force on the binding conditions of the cross-linker. For the augmin complexes studied sub-second …

    rockefeller Repository record

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