Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"linkage disequilibrium"”.
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Patterns of linkage disequilibrium in the human genome
… ever-increasing awareness of the phenomenon of linkage disequilibrium (LD). The principle behind LD is relatively simple. Over the lifetime of a population, the genetic markers that are adjacent to an ancestral mutation will recombine less often than more distant markers. Therefore, the …
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Linkage disequilibrium and haplotype block patterns in popcorn populations
Linkage disequilibrium (LD) and haplotype blocks have been a preliminary and powerful knowledge for genomic investigates in humans, animals and plants. We aimed to describe the LD measures, D’ and r 2 , and to characterize haplotype block patterns in popcorn populations (synthetic and breeding …
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Linkage disequilibrium and haplotype block structure in six commercial pig lines
O sucesso de estudos de associação e, consequentemente, a seleção genômica dependem da densidade de marcadores utilizados nas análises, a qual, por sua vez, é determinada pela extensão do desequilíbrio de ligação (LD) ao longo do genoma. O LD é organizado em blocos de haplótipos, separados por hot …
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How Linkage Disequilibrium and Recombination Shape Genetic Variation Within and Between Species
… This non-random association is known as linkage-disequilibrium (LD), and it has evolutionarily important effects both within and between species. Nucleotide diversity at a given locus may be reduced by directional selection on the locus, or by selection on neighboring linked loci. …
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GENETIC DIVERSITY AND LINKAGE DISEQUILIBRIUM IN WILD SOYBEAN, LANDRACES, ANCESTRAL, AND ELITE SOYBEAN POPULATIONS
… genome diversity and increasing the extent of linkage disequilibrium (LD). To understand the impact of these genetic bottlenecks and selection on sequence diversity and LD within soybean [Glycine max (L.) Merr.], 111 genes and three chromosomal regions located on linkage groups A2, G, and J …
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Mapping genes underlying ethnic differences in tuberculosis risk by linkage disequilibrium in the South African coloured population of the Western Cape
… frequency differences correlated with increased linkage disequilibrium in the SAC, and that the increased LD originates from admixture events rather than population bottlenecks. Secondly, we conducted a study to determine whether ancestry-specific genetic contributions affect tuberculosis risk. …
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Investigation into X-STR haplotype frequencies for forensic human identification in South Africa
… 0.999999999. The haplotype diversity of all four linkage groups exceeded 0.993. Linkage group 1 was the most informative, with 421 unique haplotypes. Possible linkage disequilibrium was detected in five loci pairs in male samples and three loci pairs in female samples. However, it is expected that …
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Characterizing Deleterious Genomic Mutations in Simulated Populations Under Some Biologically Realistic Situations
… different stages, and in finite populations with linkage disequilibrium. The investigation was implemented under constant, variable and epistatic mutation effects. I find that generally the estimation by the DENG-LYNCH method is fairly robust if the selfing rate (S) is less than 0.10 in …
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Statistical and Computational Methods to Dissect Ancestry-Biased Germline Effects in Lung Cancer
… European and Japanese biobanks. Using stratified linkage disequilibrium regression in conjunction wit gene expression-based and epigenetic annotations, we derive cell-types and biological processes associated with lung cancer and smoking in both populations.
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Network-based approach for post genome-wide association study analysis in admixed populations
… method applies centrality measures within linkage disequilibrium (LD) on the network to search for pathways and applies a scoring summary statistic on the resulting pathways to identify the most enriched pathways associated with complex diseases.
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Efficient analysis and storage of large-scale genomic data
… framework to efficiently compute genome-wide linkage-disequilibrium in datasets with up to 67 million samples resulting in up to >60-fold improvements in speed for dense genotypic vectors and up to >250,000-fold savings in memory and >100,000-fold improvement in speed for sparse genotypic …
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Evolutionary Genetics of Dictyostelids: Cryptic Species, Sociality and Sex
… of D. discoideum to look for a decrease in linkage disequilibrium as a molecular sign of sex. Linkage disequilibrium is higher between physically close loci than between loci on different chromosomes. From this, I conclude that D. discoideum undergoes recombination in nature. Lastly, I used …
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Characterisation Of Cytokine Gene Polymorphisms In Patients With Acute Pancreatitis
… that a number of haplotypes exist as well as linkage disequilibrium across all 4 loci of the IL-10 gene, which contrasts with findings from previous work. The 3 locus haplotypes GCC and ATA are in strongest linkage disequilibrium, as is the microsatellite allele G9 and -1117.A and G9 with the …
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Sampling for conditional inference on contingency tables, multigraphs, and high dimensional tables
… sampling method to the analysis of multimarker linkage disequilibrium data and also demonstrate excellent performance.
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Molecular investigation of the trinucleotide repeats within the Huntington disease gene in Southern Africa
… disease-causing (CAG)n repeat, which is in linkage disequilibrium on HD chromosomes. This study was undertaken to investigate the polymorphic repeats; (CAG)n and (CCG)n within the HD gene, in a sub-group of HD patients and family members from a population where HD is infrequently observed. …
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Inherited risk for common disease
Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular diseases, and diabetes. Such studies, however, depended on the untested …
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The role of the HLA region in Hashimoto’s Thyroiditis
… As the HLA gene region is an area of strong linkage disequilibrium this additional screening is also required to determine the primary associated loci. The data presented in this thesis provides further evidence for a difference in the aetiology of Hashimoto’s thyroiditis compared to that of …
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A More Holistic Analysis of Privacy Risks in Transcriptomic Datasets
… all known eQTLs with necessary calibration for linkage disequilibrium and redundant predictive signals. We demonstrate improved linking accuracy of DSM compared to two existing approaches on a range of real datasets including up to 22K individuals, suggesting that DSM helps uncover a substantial …
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Fine Mapping and Evolution of a QTL Region on Cattle Chromosome 3
… haplotypes of offspring were then used to define linkage disequilibrium (LD) within the QTL critical region. There were 15 LD blocks found to be shared among all three sires, covering 0.5 Mbp within the 9.7 Mbp region. These regions may contain QTL alleles carried by all three sires. Fst analysis …
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