Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"linear energy transfer"”.
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Micronuclei induction in AG01522 cells is independent of temperature and linear energy transfer
… of temperature as an experimental parameter and linear energy transfer (LET) dependence on the bystander effect. Using the micronucleus assay and primary human AG01522 fibroblast cells co-cultured as both the target and bystander cells, the incidence of micronuclei in both X-ray irradiated and …
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“Acid-spike” effect in spurs/tracks of the low/high linear energy transfer radiolysis of water : potential implications for radiobiology and nuclear industry
… formed within spurs or tracks of the low or high linear energy transfer (LET) radiolysis of pure, deaerated water at early times. The in situ radiolytic formation of H3O+ renders the spur and track regions temporarily more acid than the surrounding medium. Although experimental evidence for an …
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Development of Lineal Energy Spectrum-Based Biological Effects Models for Protons
… of microdosimetric spectra (specifically, lineal energy) for protons. SuperTrack, a GPU-accelerated tool for calculation of microdosimetric spectra was developed and is capable of computing lineal energy spectra up to 5000x faster than using Geant4 directly. Proton lineal energy spectra generated …
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The measurement of gamma ray-induced heating in a mixed neutron and gamma ray environment
… differences inherent to radiations of different linear energy transfer coefficient (LET), which are observable in a proportional counter. The operating limits of this measurement technique were explored by varying the counter position in the low-Z lattice, hence changing the irradiation spectrum …
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Combined methods and instrumentation for dosimetric monitoring of the large fluence hadron irradiations /
… Then radiation dose refers to the amount of energy deposited in matter and biological effects of radiation. The dose measurement unit is the gray (Gy) which defines the unit radiation energy deposited per mass unit (J/kg). This kind of dosimetry is used extensively for radiation protection. …
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Didelių įtėkių hadronų apšvitų dozimetrijos kombinuoti metodai ir įranga /
… Then radiation dose refers to the amount of energy deposited in matter and biological effects of radiation. The dose measurement unit is the gray (Gy) which defines the unit radiation energy deposited per mass unit (J/kg). This kind of dosimetry is used extensively for radiation protection. …
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Evaluation of Radiobiological Effects in Intensity Modulated Proton Therapy : New Strategies for Inverse Treatment Planning
… calculations of the dose averaged linear energy transfer (LET) as a measure of the local radiation quality, and on a simple phenomenological approach for the RBE as a function of dose, LET and tissue type. It was found that the biological effect depended strongly on the type of …
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Radiobiology of normal rat lung in Boron Neutron Capture Therapy
… and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological effectiveness factors for the lung. Rat thorax irradiations …
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Radiation Damage in CMOS Image Sensors for Space Applications
… used for Earth observation. Damage from high energy protons in the space environment decreases the Charge Transfer Efficiency (CTE) and increases the dark current of such devices. Experimental work on proton damaged devices is presented, showing the effects on CTE and dark current. The results …
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Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent
… tumors display resistance to traditional low linear energy transfer (LET) external beam radiotherapy (EBRT), instigating interest in finding alternative and more effective means to treat these tumors. 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) has shown clinical usefulness in …
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Treatment planning for manifold multi-ion particle therapy
… to control both the dose distribution and the linear energy transfer of the radiation throughout the target. However, to date, there has been little research into the potential for going beyond a very limited number of ion species in a single treatment plan due to the limitations of current …
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Experimental approaches for the production of thorium-229
… in the body, where it decays by releasing high-energy (5-8 MeV) α-particles with high linear energy transfer (LET) over a short (50-100 µm) range and relatively low toxicity to the rest of the body. Actinium-225 is an ideal radioisotope for TAT due to its short half-life (t1/2=9.92 days) and 3 …
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Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy
… damages. CDD complexity increases with rising linear energy transfer (LET) of radiation, while repairability decreases. This makes high-LET IR more biologically effective than low-LET. Understanding DNA repair mechanisms and associated signalling with radiation quality, may be useful in …
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Dosimetry calibration for low-energy protons produced in the ECU accelerator laboratory
… their ability to deposit the majority of their energy within a well-defined and localized volume inside the body, thereby maximizing tumor dose while minimizing irradiation of surrounding healthy tissues. Despite these advantages, continued experimental and methodological studies are required to …
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Radiation effects in metal-oxide-semiconductor capacitors
… result of the dissipation of the conduction band energy. A study of radiation-induced dielectric breakdown has revealed the possibility of anomalous hot-electron injection to an excess of bulk oxide traps in the ionization channel produced by very heavily ionizing radiation, which leads to …
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Modeling Proton Relative Biological Effectiveness Using Monte Carlo Simulations of Microdosimetry
… of the Bragg peak, a narrow region of rapid energy loss. Proton therapy is also known to offer an enhanced relative biological effectiveness (RBE) compared to photons. In the current clinical standard, RBE is fixed at 1.1 at all points along the proton beam, meaning protons are assumed to …
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Modification and Implementation of The Rpc Heterogeneous Thorax Phantom For Verification of Proton Therapy Treatment Procedures
… was measured using a CT scanner. The relative linear stopping power (RLSP) of these materials was measured. The linear energy transfer (LET) of Gafchromic EBT2 film was analyzed utilizing parallel and perpendicular orientations in a water tank and compared to ion chamber readings. Both parallel …
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Assessing The Potential Clinical Impact of Variable Biological Effectiveness In Proton Radiotherapy
… clustered nature of DNA damage produced by the energy deposition of protons along their tracks in medium. This effect is currently quantified in clinical settings by assigning protons a relative biological effectiveness (RBE) value of 1.1 corresponding to 10% increased effectiveness compared to …
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The Importance of Dna Repair Capacity to (And A Model to Predict) Cell Radiosensitivity to Ions
… repair decreases with increasing ion linear energy transfer.</p> <p>Finally, we created an empirical model to predict cellular radiosensitivity to ions on the basis of that cell’s radiosensitivity to photons, and showed that this model can predict the response of cells with differing …
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Applications of Voronoi partitions in particle therapy
… therapy, which includes dose optimization, energy modulation change reduction, and LET (linear energy transfer) painting. Generally speaking the goal of treatment planning is to use computer based algorithms and software to find a therapeutic plan that maximizes the dose' delivered to the …
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