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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 108 for “"lineage-specific"”.

  1. Modulation of lineage-specific cell differentiation by long non-coding RNAs

    Alvarez, Juan (Juan Rene Alvarez Dominguez)Massachusetts Institute of Technology2015

    … many are tissue- and developmental stage-specific, suggesting roles in lineage-specific development. We generated deep transcriptome surveys from differentiating mouse red blood cells, and implemented a computational strategy for de novo lncRNA discovery to comprehensively catalog …

    mit Repository record

  2. Novel Lineage Specific Genes Expressed in Cattle Placenta: Discovery, Functional Annotation and Evolution

    Kumar, Charu GuptaUniversity of Illinois at Urbana-Champaign2015

    … whether they represent genes that have undergone lineage-specific changes, comparative genomics tools were used to generate phylogenetic profiles to determine the presence/absence of novel lineage-specific genes (LSGs) in various clades. The detailed analysis of gene sequence alignments allowed us …

    uiuc Repository record

  3. Insights into the rice and Arabidopsis genomes: intron fates, paralogs, and lineage-specific genes

    Lin, Haining2009

    … function but also in the distribution of specific gene function. We</p> <p>showed that a significant portion of the duplicated genes in rice show divergent</p> <p>expression although a correlation between sequence divergence and correlation of</p> <p>expression could be seen in very young …

    iastate Repository record

  4. Pre-programmed regulatory networks and poised chromatin potentiate lineage-specific differentiation of CD4+ T cells

    Raubitschek, Antony C.2014

    … interactions of transcription factors (TFs) with specific regions of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which are identified globally across T cell subtypes, demonstrates that the chromatin of …

    washington Repository record

  5. Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework

    Zhang, YangUniversity of Illinois at Urbana-Champaign2016

    … to be a major contributor to the evolution of lineage-specific traits. Although transcription factor binding events show substantial variation across species, most computational approaches to study regulatory elements focus primarily upon highly conserved sites, and rely heavily upon multiple …

    uiuc Repository record

  6. Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome

    Lo, Yuanxi Motohiro FranklinUniversity of Cambridge2025

    … hypothesised that this discrepancy arises from lineage-specific differences in the regulation of the TGF-β signalling pathway. To investigate this pathway, we used patient-derived induced pluripotent stem cells (iPSCs) carrying a heterozygous TGFBR1+/R487Q mutation and its mutation-corrected …

    cambridge Repository record

  7. Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.

    Rapisarda, ValentinaUniversity of Bradford2015

    … multipotent progenitor cells establish tissue-specific gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of adhesion molecules and …

    bradford Repository record

  8. REPROGRAMMING LUNG FIBROBLASTS INTO LUNG PROGENITORS

    Kidiyoor, AmrithaWake Forest University2018

    … reprogrammed into neural, cardiac and hepatic lineages using forced expression of lineage-specific transcription factors. This strategy offers the possibility of regenerating damaged tissue in vivo by reprogramming resident cells to stimulate tissue regeneration. If resident fibroblasts within …

    wfu Repository record

  9. APPLICATIONS OF MICROARRAYS AND STEM CELLS FOR REGENERATIVE MEDICINE

    Hipp, JenniferWake Forest University2009

    … will ensure the quality of the cells, the specificity of differentiation, and the assessment of mixed phenotypes. Microarray analysis measures the global expression of genes and can provide insight into the genetic programs expressed in stem cells. A novel in silico dissection method based …

    wfu Repository record

  10. SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma

    Wesolowski, LudovicUniversity of Cambridge2022

    Lineage-specific transcription factors have emerged as a promising class of essential genes in cancer. The best examples of leveraging this phenomenon in the clinic is targeting the androgen receptor and the oestrogen receptor in prostate and breast cancer respectively. Despite the success of these …

    cambridge Repository record

  11. Computational approaches for analyzing regulatory regions in the human genome

    Zhang, YangUniversity of Illinois at Urbana-Champaign2018

    … to consolidating versatile genomic data. Specifically, we developed three computational algorithms/frameworks to decipher the complex functions of the human CRE: 1) in the evolutionary context of comparative genomics, 2) in the context of cancer somatic mutations, and 3) in the context of …

    uiuc Repository record

  12. Niche-adaptive evolution in Campylobacter jejuni

    Morley, LNottingham Trent University2014

    … Complex, a previously identified C. jejuni lineage associated with the porcine host. ST403CC C. jejuni have also been linked with other mammalian hosts to a lesser degree, and have been implicated in human campylobacteriosis, however to date this clonal complex has not been linked to …

    nott-trent Repository record

  13. Magnaporthe Oryzae Telomeric Retrotransposon (moter) Relics Further Highlight Telomere Dynamics In A Rapidly Evolving Fungal Pathogen

    Dostart, Jane EllenEastern Kentucky University

    … to document telomere instability among strain lineages, as well as to uncover MoTeR relic distribution, shared evolutionary history, and associated genome rearrangements. A series of local BLASTn and grep searches in the Unix Command Line were used to find and describe MoTeR relics. We found …

    eku Repository record

  14. Epigenetic Regulation of Skin Development and Postnatal Homeostasis The role of chromatin architectural protein Ctcf in the control of Keratinocyte Differentiation and Epidermal Barrier Formation

    Malashchuk, IgorUniversity of Bradford2018

    … play important roles in the control of lineage-specific differentiation during development. However, mechanisms that regulate higher-order chromatin remodelling and transcription of keratinocyte-specific genes that are clustered in the genome into three distinct loci (Keratin type I/II …

    bradford Repository record

  15. Gene duplication and the evolution of the higher diptera

    Bao, Riyue2012

    … available genomic information, I studied lineage-specific gene duplications in <i>Drosophila melanogaster</i> (fruit fly), <i>Anopheles gambiae</i> (mosquito), <i>Tribolium castaneum</i> (red flour beetle), and <i>Apis mellifera</i> (honey bee) at three scales: eye-specific genes, …

    wayne-thes Repository record

  16. Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons

    Mona, Bishakha2021

    … is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is dependent on spatio-temporally …

    utswmed Repository record

  17. Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation

    Muthukrishnan, Rajarajeswari2009

    … GTPase Rac2 is expressed in hematopoietic cell lineages and is further up-regulated upon terminal myeloid cell differentiation. Rac2 plays an important role in many hematopoietic cellular functions, such as neutrophil chemotaxis, superoxide production, cytoskeletal reorganization, and stem cell …

    iupui Repository record

  18. Structural and Computational Studies of RNA Polymerase

    Lane, William J

    … structure, with little focus on the bacterial lineage-specific domain insertions. Furthermore, we lack information about the hidden functional residue networks that underlie the activities of this complex multi-subunit molecular machine. By combining structural and computational methods we: (1) …

    rockefeller Repository record

  19. THE ROLE OF NON-MUSCLE MYOSIN IN TENDON AND ATTACHMENT UNIT FORMATION AND MATURATION

    Evans, Mary, Katharine2025

    … bone. To test this hypothesis, we generated cell-lineage specific transgenic knockout mice to specifically delete NM-II in Prrx1 (limb mesenchyme) or Scx (tenogenic) lineage cells. In Chapter 2, we found that deletion of the predominant NM-II isoforms, NM-IIA (Myh9 gene) and NMII-B (Myh10 gene) …

    penn Repository record

  20. Rates of Molecular Evolution and Phylogenomic Inference

    Li, Wai LokResearchSpace@Auckland2010

    … data. Developments were made to the area of lineage-specific variation in evolutionary rates, with improvements in more efficient computational implementations of relaxed molecular clock models and the proposal of new models of rate changes across branches. The practical application of …

    auckland-ms Repository record

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