Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"lineage restriction"”.
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Neuromeric organization of the midbrain-hindbrain boundary region in zebrafish
… the cellular level: Each neuromere comprises a lineage-restricted population of cells that does not intermingle with cells from neighboring compartments. The units of the vertebrate hindbrain, the rhombomeres, serve as the best-studied examples of neuromeres. Here, the lineage restriction …
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Mechanism of cell adhesion at the midbrain-hindbrain neural plate in the teleost Danio rerio
… (mhb) in the zebrafish is a compartment (or lineage restriction) boundary I tried to understand the underlying molecular mechanism for its correct establishment. In this work I focused both on embryological, molecular and genetic means to characterize involved molecules and mechanisms. In the …
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Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour
… from the early embryo retain the identity and lineage restrictions of their embryonic counterparts: embryonic stem cells (ESCs) are pluripotent and similarly to ICM contribute to all tissues in the embryo proper, being generally excluded from the extraembryonic layer. On the other hand, …
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Early Blood Cell Formation "in sickness and health, ´till death do us part"
… to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood cells can change dramatically in cases like bleeding and infections. In addition to the production of differentiated offspring, HSC possess the ability to undergo self-sustaining …
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Functional and Transcriptional Heterogeneity of the Human Haematopoietic Stem Cell Pool at Steady-State and Under Inflammation
… stem cells (HSCs), downstream of which lineage-restricted progenitors are generated. The advent of single cell technologies has changed our view of the haematopoiesis to a dynamic continuum. Understanding the early differentiation trajectories of HSCs, and how environment and molecular …
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Characterisation of human Haematopoietic Stem Cell differentiation and exit from quiescence at single cell resolution
… HSCs) and to understand when the first steps of lineage restriction occur during HSC differentiation. Moreover, I use an in-vitro model system to comprehensively study HSC activation and to investigate whether HSC self-renewal is lost during quiescence exit or during cell cycle progression. …
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Mechanical mapping of lineage boundaries in the developing Xenopus laevis embryo
… embryo found in literature, along with my own lineage tracing. First, I determined that the presence of the vitelline membrane obscures the mechanical properties of the embryo below, and so must be removed, and that the AFM could reliably measure embryonic tissue up to an angle of 21° from …
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Cell Fate Decisions in the Developing Lung
… lung compartments, and what factors promote lineage-restriction and competence loss are questions that remain to be addressed. Exposure to glucocorticoids has previously been demonstrated to accelerate lung maturation (Laresgoiti et al., 2016). However the changes in tip cell fate decisions …