Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"lineage priming"”.
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The Role of p66Shc in Stem Cells: Signalling, Identity and Apoptosis
… restraining ERK–STAT3 signalling to promote lineage priming. In NSCs, p66Shc loss conferred resistance to apoptosis induced by epidermal growth factor (EGF) withdrawal, EGF-receptor inhibition, or MEK inhibition, but not to classical mitochondrial oxidants. These results support an …
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Toll Like Receptor Dependent Control of T Helper 17 Cell Differentiation and Inflammasome Activation
… of CD4+ T cells. While IL-12 is critical for Th1 lineage development, IL-6 and TGF-b play an important role in differentiation of Th17 cells in vitro. IL-1 has also been implicated in regulating Th17 differentiation. In this dissertation, we examined the relative contribution of IL-6 and IL-1 for …
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Multi-omics characterisation of mouse gastrulation and organogenesis at single-cell resolution
… environment and (2) DNA methylation in cell lineage priming and specification during embryonic development. To better understand the spatial environment's role on cell fate specification (Aim 1), we used the image-based single-cell transcriptomics method, seqFISH, to precisely measure the …
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Single-cell Protein-Transcriptome Atlas of Haematopoiesis across the Human Lifespan
… circulating blood cells. Proper regulation of lineage decisions is key to ensure the right balance between the generation of differentiated cells and the maintenance of the haematopoietic stem cell compartment. A dysregulation in this balance can lead to blood-related diseases. Throughout an …
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Hematopoietic Stem Cells and Progenitors in Murine Autoimmune Arthritis
<p>Although the physiological role of stem cells in generating and maintaining a functional biological system is widely appreciated, very little is known about the behavior of these cells in pathological conditions. If and how these primitive cells are affected by a disease process or may …