Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"limk1"”.
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The Role of LIM Kinase 1 and its Substrates in Cell Cycle Progression
<p>LIM Kinase 1 (LIMK1), a modulator of actin and microtubule dynamics, has been shown to be involved in cell cycle progression. In this study we examine the role of LIMK1 in G1 phase and mitosis. We found ectopic expression of LIMK1 resulted in altered expression of p27Kip1, the G1 phase Cyclin …
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Role of Actin and its regulating proteins in drug response
… of the actin regulating proteins, LIM kinases (LIMK1 and LIMK2) in drug resistance. In addition, the role of γ actin, a major actin isoform, in drug resistance was also examined. Chapter 1 reviewed the known mechanisms of antimicrotubule drug resistance and the interaction between the …
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Identification of cellular signaling events dysregulated in Huntington’s disease.
… cytoskeletal signaling, and in particular LIMK1/cofilin/slingshot signaling, was dysregulated in HD NSC’s. GSK3β was reported as a major upstream kinase potentially activated in the HD NSCs by NetworKIN analysis, an online tool. These changes in cytoskeletal associated signaling align with …
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Aplicación web interactiva para minería de textos: Análisis del Síndrome de Williams-Beuren
… genes, como GTF2I, GTF2IRD1, GTF2IRD2, ELN, LIMK1, STX1A, BAZIB, BCL7B y F2D9, en el cromosoma 7 en la posición 11.23. Este trastorno del neurodesarrollo puede provocar entre otras enfermedades, estenosis aórtica supravalvular, hipersociabilidad, deficits en cognición social, pérdida auditiva …
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Regulation of Cell Migration by WNK1
… 3-kinase (PI3K), including Akt and LIMK1; 3. Regulation of proteins that control the cytoskeletal re-organization including the ERM proteins (Ezrin, Moesin, and Radixin), cofilin, and the Rho family of GTPases, including RhoA and Rac1.
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Regulation of human protein kinases and phosphatases by 14-3-3
… possibly by phosphorylating substrates such as LIMK1 and GEF-H1. PAK7 shares common substrates with PAK4 and probably has a redundant role in regulating migration of melanoma cells.<br/><br/>Overall, the work in this thesis gives a broader view on integration of the complex networks of signaling …