Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"limb development"”.
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Studies in Amphibian Limb Development and Regeneration
… to investigate the phenomenon of amphibian limb regeneration. However, these past experiments have not attempted to apply rigorous statistical methods to analyze specific whole limb and regeneration blastema events. The most interesting of these events are those that occur during the …
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Genomic Regulation of the Shox2 Gene during Mouse Limb Development
… as protein-coding sequences in the etiology of developmental diseases. Conditional knockout of murine Shox2 in limbs specifically disrupts chondrogenesis and the development of the humerus and femur, and is phenotypically similar to human SHOX-deficient patients, albeit different proximodistal …
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Cross-species microarray analysis of limb development in the bat, Miniopterus natalensis
… the first characterisation of the embryonic bat limb transcriptome, allowing the identification of novel candidate genes that were differentially expressed between the bat hand and foot plate. These genes may have played important roles in the evolution of the bat wing and hindlimb. The …
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Targeted Deletion of Functionally Validated Enhancers Defines Their Role In Mouse Limb Development
… of enhancers, during embryological and postnatal development is essential to an understanding of evolutionary processes and disease etiology. Numerous methods are in use to identify and characterize enhancers. Several high-throughput methods generate large datasets of enhancer sequences with …
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A Comparison of Limb Development of the Salamanders Plethodon Cinereus and Ambystoma Mexicanum
Tetrapod limbs exhibit a wide variety of developmental variation. Amphibians alone display a fair amount this variation. Here, the development of both limb pairs in the species Plethodon cinereus and Ambystoma mexicanum are compared. Using histology and microCT on embryonic and juvenile specimens, …
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Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
… of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene knockout studies have demonstrated that dHAND and eHAND null embryos die from defects in right ventricular and …
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The Interaction of a Mutant Gene, Paddlefoot (Pf), and a Teratogen, 6-Azauridine, on Limb Development in Two Inbred Strains of Mice.
… environmental agents acting alone will induce developmental malformations. Within the past twenty-five years, more attention has been given to the interaction of the whole genome and specific mutant genes with either chemical or physical teratogens. Results of such studies have been reported in …
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Disruption of apoptosis and WNT signaling during limb morphogenesis by exogenous retinoic acid: a case study in Monodelphis domestica
… properties. RA is essential for normal limb development; but too much RA results in defects such as digit reduction and truncation of the limb. During normal limb morphogenesis, two signaling centers, the apical ectodermal ridge (AER) and the zone of polarizing activity (ZPA), regulate …
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Digit formation during embryonic development of bats and mice
… HL, has seen extensive research into bat wing development in an effort to determine the molecular mechanism driving limb development. A recent RNA-seq and ChIP-seq study carried out on M. natalensis showed differences in FL and HL activity for several genetic pathways known to be involved in …
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Environmental, Landscape, and Host-Related Factors Associated With Parasitism and Its Effects on Larvae and Metamorphic Frogs of Rana Pipiens
… were exposed to cercariae at different stages of development and monitored for survival and, in the case of R. ondatrae, for abnormal limb development. For both parasite species, survival was dependent upon the developmental stage of tadpoles at the time of infection. Individuals infected with …
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PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL
… family member, plays a crucial role in embryonic development of stratified epithelia where it can function either as an activator or a repressor. In the epidermis, p63 is a master regulator of epidermal gene expression and is crucial for cell proliferation, cell adhesion and stratification. Here …
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Mouse Embryo Development in the Presence of Capsaicin
… and the effect of the capsaicin on embryo development was measured. Embryos were co-cultured in Krebs medium with 1% ethanol and from 1 to 3mM capsaicin. The higher levels of capsaicin significantly inhibited embryo development. Post implantation fetuses were treated in the dam with 0.3, …
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Quantitative Characterization of Conserved Noncoding Regions by Flow Cytometry
<p>Spatial and temporal regulation of developmental gene transcription often involves regulatory sequences found in noncoding DNA separate from the gene’s promoter. Conservation of a noncoding region (CNR) across divergent species may indicate a regulatory region critical to basic morphogenesis. …
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VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
… process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; Shepard et al., 2007) and the knockdown of versican leads to malformation of the interzone, tissues that form the …
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
The limb buds of the early embryo are formed at the lateral flank by an outgrowth of cells from a layer of embryonic tissue called the lateral plate mesoderm. Shortly after this initial outgrowth, cells from the lateral edges of adjacent developing tissue invade the limb bud to form the muscles, …
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Xenobiotic Metabolism Genes and Clubfoot
… both maternal and fetal genotypes impact normal limb development. No association was found for maternal smoking status and tobacco metabolism genes. Together, these results suggest that xenobiotic metabolism genes may play a contributory role in the etiology of clubfoot regardless of maternal …
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The role of the wingless gene in the control of growth and pattern formation during drosophila wing development
Recent work on Drosophila limb development has indicated that short-range interactions between distinctly specified populations of cells (compartments) establish organizing centers at compartment boundaries. These organizing centers direct pattern formation and growth in the developing limbs. In …
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H36-alpha7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis
… mRNA is regulated both early in the development of the myogenic lineage and later, during terminal differentiation. Detection of H36-$\alpha$7 mRNA coincides with conversion of H36$\sp-$ myogenic precursor cells to H36$\sp+$ cells. H36-$\alpha$7 mRNA is present in replicating …
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