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Showing 1 to 17 of 17 for “"limb bud"”.
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The Misexpression of Sonic Hedgehog Leads to Digit Duplication
The limb buds of the early embryo are formed at the lateral flank by an outgrowth of cells from a layer of embryonic tissue called the lateral plate mesoderm. Shortly after this initial outgrowth, cells from the lateral edges of adjacent developing tissue invade the limb bud to form the muscles, …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
… DMSO to the anterior margin of a stage 20 chick limb bud which was then observed at stage 36 for signs of abnormal development such as digit duplication. Occurrence of digit duplication would suggest that AT retinol had been metabolised to ATRA, a known inducer of teratogenic effects, within the …
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Maternal Effects on Embryonic and Placental Growth and the Penetrance of the Luxate Gene in Mice.
Preaxial polydactyly is one of the most frequent limb anomalies in man, and sporadically occurs in poultry, pigeons, and in the hindlimbs of cats, dogs, mice and guinea pigs (Carter, 1954). Polydactyly is detectable by the stage of footplate morphogenesis, but it is inducible before hind-limb bud …
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A Comparison of Limb Development of the Salamanders Plethodon Cinereus and Ambystoma Mexicanum
Tetrapod limbs exhibit a wide variety of developmental variation. Amphibians alone display a fair amount this variation. Here, the development of both limb pairs in the species Plethodon cinereus and Ambystoma mexicanum are compared. Using histology and microCT on embryonic and juvenile specimens, …
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ΥΠΕΡΑΡΙΘΜΟΙ ΑΝΑΓΕΝΝΗΤΙΚΟΙ ΣΧΗΜΑΤΙΣΜΟΙ ΚΑΤΑ ΤΗΝ ΟΝΤΟΓΕΝΕΣΗ ΤΟΥ ΑΚΡΟΥ ΣΤΟ ΑΝΟΥΡΟ BUFO BUFO
… OF "PATTERN FORMATION" THE REGULATION OF THE LIMB OF BUFO BUFO ALONG THE PROXIMODISTAL AXIS AND THE CREATION OF SUPERNUMERARY FORMS, WERE STUDIED. FOR THIS REASON WE RESEARCHED THE DISTAL TRANSFORMATION OF THE LIMB IN DIFFERENT STAGES OF DEVELOPMENT AND AMPUTATION LEVELS AND THE INTERCALARY …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… neurons that have extended their axons and that limb bud ablation before motor axon outgrowth prevents this induction, suggesting a trophic role from the developing limb. Consistently, NRG1 induction after limb bud ablation can be rescued by adding back the neurotrophic factors BDNF and GDNF. …
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Natural History and Ecology of the Flatwoods Salamander, <em>Ambystoma cingulatum</em> on the Atlantic Coastal Plain
… Atlantic Coastal Plain prior to metamorphosis. Limb bud development is analyzed and measurements on larvae from the Atlantic Coastal Plain are presented, as are measurements on metamorphs. Conservation considerations are discussed and analysis of seasonal activity patterns from 1963-2000 reveal …
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Analysis of the Function of Megf7 During Development
… of the transmembrane domain, had defects in limb, tooth, and mammary gland development. Subsequent analysis showed that the defects in limb development were caused by the expansion of the limb bud structure called the apical ectodermal ridge. Biochemical analysis suggests that Megf7 acts as …
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Delineating the molecular mechanisms regulating chondrogenesis
… Sox9 during chondrogenesis, the developing mouse limb was used to identify and characterize regulatory regions within the Sox9 promoter. Luciferase-based reporter assays in mouse revealed a proximal promoter spanning – 2 kb from the transcriptional start site, while mobility shift assays …
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Environmental, Landscape, and Host-Related Factors Associated With Parasitism and Its Effects on Larvae and Metamorphic Frogs of Rana Pipiens
… and, in the case of R. ondatrae, for abnormal limb development. For both parasite species, survival was dependent upon the developmental stage of tadpoles at the time of infection. Individuals infected with either of the parasites at early tadpole stages (Gosner [1960] 24--25) experienced …
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Investigating the chromatin dynamics of gene activation
… central nervous system, gut and the posterior limb bud. This complex pattern of expression is regulated by the activity of multiple tissue-specific enhancers which are spread through a 1 Mb genomic desert. Many of these enhancers activate Shh expression over large genomic distances, with some …
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Developmental dynamics of posterior segment addition in the spider Parasteatoda tepidariorum
… opisthosomas with irregular surfaces and delayed limb-bud formation on the fourth leg-bearing segment, although opisthosomal segmentation proceeded. These results suggest that there are three cell states during opisthosomal segmentation: (1) the SAZ, a posterior segmentation organiser; (2) the …
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Die Rolle von cDermo-1 und cTwist im Vogelembryo
… of cDermo-1 in the back as well as the limb bud of the chick embryo resulted in the formation of ectopic dermis and skin appendages with respect to the position of the dermis within the embryo. This shows that cDermo-1 is a universal inducer of skin appendages and does not carry a …
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Der monoklonale Antikörper Som5H5 : Charakterisierung seines Antigens in der Embryonalentwicklung des Hühnchens
Das Ziel der vorliegenden Arbeit war es, das Antigen des <br>monoklonalen Antikörpers Som5H5 zu bestimmen und es <br>hinsichtlich seines Auftretens in der frühen <br>Embryonalentwicklung des Hühnchens zu charakterisieren. Mit <br>Hilfe verschiedener biochemischer Verfahren wurde das …
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Targeted Deletion of Functionally Validated Enhancers Defines Their Role In Mouse Limb Development
… development of specific structures, such as the limb. Manipulation of enhancers at their endogenous loci, such as the deletion of such elements, leads to a better understanding of the regulatory interactions, rules and complexities that contribute to faithful and variant gene transcription – the …
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A Molecular Dissection of the Ventromedial Hypothalamic Nucleus
… to a presumed transcription factor called limb bud and heart (LBH). To further examine the expression of this gene in the VMH, and to begin to describe VMH neuronal populations, we created LBH2-GFP BAC transgenic mouse line expressing GFP under the control of the LBH2 promoter. These mice …
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Dynamic patterning of maternal mRNAs in the Early C. elegans embryo
… is essential to the outgrowth of a growing limb bud. Induction and maintenance of the AER reply heavily on the coordination and signaling between two surrounding cell types: ectodermal and mesenchymal cells. In morphogenesis during embryonic development, a process called the …