Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"lignans"”.
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The study of the asymmetric synthesis of lignans
… thesis focuses on the asymmetric synthesis of lignans by approaches such as Diels-Alder reactions, asymmetric alkylation reactions, and intramolecular oxidative coupling reactions. In addition to developing asymmetric synthetic methodologies for chiral lignans, an investigation of chirality in …
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Antioxidant properties of flaxseed lignans using in vitro model systems
… the antioxidant properties of flaxseed lignans secoisolariciresinol (SECO 2) and secoisolariciresinol diglycoside (SDG 1) and their major oxidative compounds using 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH 47) in an in vitro model of lipid peroxidation. This investigation was …
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Evaluation of a modified food frequency questionnaire to measure lignans in Australian men and women
… against chronic diseases. Isoflavonoids and lignans are two main classes of phytoestrogen that have been investigated for their estrogenic efficacy and occurrence in the human diet. Isoflavonoids are found in soy and related products, whereas lignans are found in a wider range of plant-based …
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The Comparison of Rat and Human Intestinal and Hepatic Glucuronidation of Enterolactone Derived from Flaxseed Lignans
The mammalian lignan, enterolactone (EL), is a gut microbe metabolite of plant lignan secoisolariciresinol diglucoside (SDG), which is most abundant in flaxseed. Numerous epidemiological, experimental and clinical studies suggest the protective effects of EL against various chronic diseases such as …
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Synthesis of Lignans Utilising the Acyl-Claisen Rearrangement: Total Syntheses of (+)-Ovafolinin A, B, (–)-Bicubebin A, B and (+)-Bicubebin C
Lignans are a diverse class of natural plant products which continue to provide new chemical structures as potential biologically active compounds. The recent syntheses of lignans has allowed for the development of new synthetic methods, confirmed or corrected proposed structures for these natural …
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PHYTOCHEMICAL AND SYNTHETIC INVESTIGATIONAL COMPOUNDS AS MODULATORS OF CYTOMETABOLIC AND CYTOSKELETAL DYNAMICS FOR PRE-CLINICAL TARGETING OF PROSTATE CANCER
… and putative mechanisms of action for the lignans, enterolactone and isoalantolactone, and to identify other potential drug candidates for targeting PC cytometabolic and cytoskeletal stress vulnerabilities, in several different heterogeneous sub-types of PC by the use a myraid of in vitro …
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Local effects of Linoorbitides and enterolactone On intestinal epithelial functions
… several known bioactives including fibers, lignans, alpha-linolenic acid, and linoorbitides (LOBs) are believed to impart those pharmacological activities. Previous studies have focused on the ability of flaxseed bioactives to provide their pharmacological action in the systemic circulation. …
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NATURAL POLYPHENOLS AS LEAD COMPOUNDS IN THE SYNTHESIS OF ANTITUMOR AGENTS AND OTHER USEFUL PRODUCTS
… Abstract Some polyphenol dimers, such as lignans, neolignans and stilbenoid lignans, because of their biological properties as well as their structural variety, are an attractive target for chemical synthesis or modification. These polyphenols may be considered lead compounds to obtain …
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Synthesis of lignin-carbohydrate model compounds and neolignans
… there are many secondary metabolites such as lignans, neolignans, tannins and terpenoids. The structures of lignans and neolignans are analogous to the interunits of lignin. Lignin is considered an optically inactive polymer, whereas lignans and neolignans are optically active small molecules. …
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NATURAL OR BIO-INSPIRED POLYPHENOLS IN THE SYNTHESIS OF POTENTIAL CHEMOTHERAPEUTIC AGENTS
… my research activity was devoted to lignans and neolignans, synthetized by chemical and/or enzimatic methodology. Hence, in particular, two polyphenol groups were studied, namely benzoxanthene lignans, their related phenazines and bisphenol neolignans; furthermore during the synthesis …
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Functional analysis of soybean dirigent genes
… to direct the synthesis of stereospecific lignans, such as (+) or (-)-pinoresinol, and lignins, from the selective coupling of specific stereoisomers of deprotonated alcohol molecules. Lignans and lignins have been shown to have antimicrobial properties and human health benefits when …
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Plant foods, plasma enterolactone and breast cancer - with a focus on estrogen receptor status and genetic variation
… might protect against breast cancer, for example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen receptors (ERs) and, therefore, inhibit the effect of estrogens. The aim of this …
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Studies on biological activities of Scottish plants.
… were 8 alkaloids, 5 coumarins, 13 flavonoids, 6 lignans, 5 secoiridoids, 3 cyanogenic glycosides, 2 diaryl heptanoids, 1 phytoecdysteroid, a cinnamic acid derivative and an acetophenone derivative isolated in this study. These included the novel compounds hederacine A, hederacine B, two tropane …
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The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
… hyperoside, and isoquercetin, and five lignans: justicidins A and B, 6-methoxyjusticidin A, chinensinaphthol, and retrochinensinaphthol methyl ether were isolated from Monsonia angustifolia and Monsonia glauca plants collected in South Africa. The extracts, the fractions, and compounds …
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Multicomponent Cyclization Reactions: A General Approach To Dibenzocyclooctadiene Lignan Natural Product
… applicable route to dibenzocyclooctadiene(DBCOD) lignans, an important class of natural products with wide-ranging biologicalactivities, we applied Pd-catalyzed bis-metallative cyclizations mediated by a [B-Sn] reagent,1-trimethylstannyl-2,5-dimethyl-2,5-diazaborolidine, to access the core DBCOD …
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Flaxseed Lignan Metabolites Modulate Hepatocellular Cholesterol Trafficking In HepaRG
… The literature indicates the ability of flaxseed lignans to improve cholesterol blood profiles. However, the mechanism by which the metabolites of the non-bioavailable plant lignan, secoisolariciresinol diglucoside, modulate blood cholesterol levels is not yet known. This study examines a possible …
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Study of podophyllotoxin biosynthesis in Podophyllum species
Lignans are a structurally diverse group of phenylpropanoid metabolites widely distributed throughout the plant kingdom. Their biogenetic pathway has generally been viewed to occur via coupling of two monomeric moieties, with subsequent modifications as required to afford the various Iignan …
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SYNTHESIS OF NATURAL-DERIVED POLYPHENOLS AS POTENTIAL ANTICANCER AGENTS
… from shikimate pathway, as phenylpropanoids and lignans, or from a mixed biosynthetic pathway (shikimate/ acetate and/or malonate pathways), as stilbenoids or flavonoids. My thesis is devoted to the family of polyphenols with the specific goal of synthesize new natural-derived polyphenols …
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Characterizing the role of dietary fat in the development and progression of liver dysfunction
… multiple other components such as fiber and lignans, and was investigated for its high potential to modify obesity phenotype and fatty liver disease. Additionally, we explored the temporal effect of initiating high-fat diets in various phases of adulthood. However, work in this field is …
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Isolation and Structure Elucidation of Anticancer and Antimalarial Natural Products
… two new and five known antiproliferative lignans from Cleistanthus boivinianus (Phyllanthaceae); two new and two known antiproliferative sesquiterpenes lactones from Piptocoma antillana (Asteraceae); one new antiproliferative 1,4-naphthoquinone, one known antiproliferative isoflovonoid, …
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