Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"ligand-receptor interaction"”.
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Characterization of heparan sulfate proteoglycan receptor from a permanent rat liver cell line
… a heparan sulfate proteoglycan (HSPG) specific receptor on the cell surface of rat liver cell (RLC), and to characterize the specificity of the ligand-receptor interaction, the properties of the receptor, and the importance of the receptor in HSPG metabolism.
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Connectomics of extrasynaptic signalling: applications to the nervous system of Caenorhabditis elegans
… is also critical to brain function. As these interactions are not visible in the physical structure of the nervous system, current approaches to connectomics are unable to capture them. This work addresses the problem of missing extrasynaptic interactions by demonstrating for the first time …
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Characterization of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) interaction with the Bovine Aortic Endothelial (BAE) cell surface: Examination of the Role of Heparan Sulfate Proteoglycans (HSPG)
… recent studies have indicated that IGFBP-3 has a receptor mediated growth inhibitory response of its own. In the present study, we quantified the binding characteristics of IGFBP-3 to bovine aortic endothelial (BAE) cells. Binding studies at 4 <sup>o</sup>C were conducted and a specific binding …
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A Lamprey Gonadotropin-releasing Hormone in the Bovine Brain
… (FSHRF). Analogs of mammalian LHRH and their receptors have been isolated in various animals; of these, the lamprey-gonadotropin-releasing hormone-IH (lampreyGnRH-IH) analog seems the most likely candidate as a possible independent FSHRF in the mammalian system. On the basis of these studies, …
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Transcription and chromatin dynamics in the Notch signalling response
… target genes in different contexts. Upon ligand binding, the Notch receptor itself is cleaved, allowing the intracellular domain to travel to the nucleus and activate gene expression with the transcription factor known as Suppressor of Hairless (Su(H)) in Drosophila melanogaster. It is …
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Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
… of cell-type–specific responses and coordinated interactions within the periodontal microenvironment. OBJECTIVE: This study aimed to compare the transcriptional landscapes of structural and immune cell populations in periodontitis versus healthy gingival tissues using single-cell analysis, with a …
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Relationship Between CB1 and S1P Receptors in the Central Nervous System
… (CB1) and sphingosine-1-phosphate (S1P) receptors in the CNS, but potential functional relationships between these lysolipid receptors have not been examined. Therefore, to investigate possible relationships between these two systems at the level of G-protein activation, …
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The structural basis of chemokine binding affinity and receptor selectivity: Role of receptor N-terminal domain
… and activating 7-transmembrane G-protein coupled receptors present on the cell surface. Ligand-receptor interaction is complex and involves a broad range of affinities and selectivities. Furthermore, receptor binding involves interaction of both monomeric and dimeric ligands. Interactions between …
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Human-Mouse Neural Crest Chimeras as a Novel Model for Human Melanocyte Biology in Development and Disease
… environment via expression of a single mouse receptor (c-Kit) on human donor cells to rescue an evolutionarily divergent ligand/receptor interaction required for melanoblast proliferation and survival. We find that this extends the persistence of human NCCs, but does not lead to postnatal …
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Molecular characterization in human neurons of genes associated with the control of bodyweight and feeding behaviour
… effects on human neurons include ‘Neuroactive ligand-receptor interaction’ and ‘negative regulation of neurogenesis’, and also ‘Respiratory chain complex I (gamma subunit) mitochondrial’. Therefore we propose that rare mutations in BSN might confer their effects on BMI through widespread …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… its effects by interacting with one of four receptors termed EPI-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. The initial aim of this study was to localise the site of expression of EP4 receptors in cervical squamous cell- and …
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Studies on the Complement Receptor of a Human Lymphoblastoid Cell Line
… used to investigate a surface marker, the C3d receptor. A method for cloning these cells at a relatively high efficiency was developed and C3d receptor bearing (CR+) and receptor free (CR-) subclones isolated. Receptor bearing cells were identified by their capacity to bind to complement coated …
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Development of Novel Chemical Biology Tools for Probing Structure-Function Relationships in G Protein-Coupled Receptors
<p>G protein-coupled receptors (GPCRs) constitute a large family of transmembrane receptors that transduce extracellular signals into intracellular biochemical responses. Understanding with chemical precision how GPCRs function in cellular membranes is an active area of biological research, but …
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Understanding Intercellular Signaling During Lung Injury-Repair
… signals either presented or secreted, known as ligands, to be received by receptors on the surface of another, or in some cases, the same cell. The alveolar region of the lung, the primary region of gas exchange, responds to various types of injuries with different lung repair mechanisms. In …