Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ligand-receptor complex"”.
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Fop-Acvr1 Signals By Multiple Modalities In The Developing Zebrafish
… domains of the type I BMP/TGFβ cell surface receptor, ACVR1, which over-activate signaling through phospho-Smad1/5 (pSmad1/5). To investigate the uncertain mechanism by which FOP-ACVR1 enhances pSmad1/5 activation, we used a zebrafish embryonic dorsoventral (DV) patterning assay for BMP …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… cell surface. One particular class of proteins, receptor tyrosine kinases (RTK), is internalized upon binding to extracellular ligands during their residence at the cell surface. The epidermal growth factor receptor (EGFR) is an RTK whose trafficking through the endocytic pathway through the cell …
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Studies of G Protein-Coupled Receptor Stability and Dimerization Using Novel Fluorescence and Crosslinking Approaches
<p>G protein-coupled receptors (GPCRs) comprise a large family of related seventransmembrane- helical membrane proteins that bind to specific extracellular ligands, such as hormones or neuromodulators. The active receptor-ligand complex then engages with a heterotrimeric G protein on the …
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Struktur- und Funktionsanalysen an BMP Ligand-Rezeptor-Komplexen
… beginnt der Signalweg mit der Bindung des Liganden an zwei Typen transmembranärer Rezeptoren. Die Ligand-Rezeptor Interaktionen sind dabei durch unterschiedliche Affinität und Spezifität gekennzeichnet und bilden wahrscheinlich die Grundlage für das breite Spektrum biologischer Funktionen. …