Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 1 of 1 for “"ligand building"”.
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In Silico-Guided Design of Novel-Scaffold Therapeutics Targeting the Dopamine D3 Receptor
… Three DFDD approaches - scaffold replacement, ligand building, and MedChem Transformations - were assessed in replacing structural portions of eticlopride, a D2/D3R-specific antagonist, to generate compounds of novel drug scaffold. Pharmacological characterization of the compounds determined …