Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ligand activation"”.
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Diphosphine Ligand Activation Studies with Organotransition-Metal Compounds
… in the presence of the diphosphine ligands 2,3-bis(diphenylphosphino)maleic anhydride (bma) and 4,5-bis(diphenylphosphino)-4-cyclopenten-1,3-dione (bpcd) furnishes the new mixed-metal complexes CoRu(CO)4(μ -P-P)(μ -PPh2) [where P-P = bma (3); bpcd (6)], along with trace amounts of …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where approximately 160 still are "orphans", meaning that the endogenous ligands are …
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Calcium Signaling Dynamics in RBL Cells Under Pulsed Ligand Exposure
… live cell imaging of cell signaling events after ligand activation. This investigation method is able to capture early events with a high temporal resolution. When coupled with fluorescence microscopy the responses of single cells loaded in the device can be measured using fluorescent reporters. …
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The effect of denticity on the electrochemistry and oxygenation kinetics of polydentate Schiff base complexes of manganese
… potentially bidentate and tridentate Schiff base ligands have been prepared. The ligands were prepared from substituted salicylaldehyde or pyridine-2-carboxaldehyde and amines with hydrocarbon or alkylpyridyl substituents. The electrochemistry and the oxygenation kinetics of these and similar …
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Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction
The aryl hydrocarbon receptor (AhR) is a ligand activated transcription factor which regulates toxic response to environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Upon ligand activation, the AhR translocates to the nucleus, dissociates from its chaperone complex, and …
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Structural basis of membrane targeting and regulation of the innate immunity adaptor TIRAP by its phosphoinositide-binding motif
… mediates the membrane recruitment of TIRAP. Upon ligand activation, TLRs are recruited to the phosphoinositide (PIP)-enriched region in the membrane, where TIRAP recruits other adaptors to the membrane to activate TLR signaling pathway. To investigate the mechanism of membrane targeting of TIRAP …
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Regulation of hepatocyte growth factor receptor endocytic trafficking
… tumor progression, metastasis and angiogenesis. Ligand activation of HGFR leads to receptor downregulation via endocytosis and lysosomal degradation, the major mechanism for terminating HGFR signaling. Perturbation of HGFR trafficking, either at the level of internalization or during sorting at …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor progression. We have analyzed the expression profiles of various Notch liagnds in 779 breast cancer patients in GEO …
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Mechanisms of Regulation of Proximal Tubule Sodium Transporters in Obesity-Induced Hypertension
… second aim we investigated the effect of PPARγ ligand activation on expression and activity of proximal tubule Na+ transporters in OP and OR rats. In addition, by employing in vitro studies using proximal tubule epithelial cells, we determined whether pioglitazone exerts its effect via direct …