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Showing 1 to 20 of 3554 for “"ligand"”.
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Metal-ligand multiple bonds in organometallic complexes containing triamidoamine ligand systems
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Investigation of the ligand shells of homo-ligand and mixed-ligand monolayer protected metal nanoparticles : a scanning tunneling microscopy study
… core surrounded by a self-assembled monolayer of ligands (a 3-D SAM or ligand shell), their appeal and utility stem from their numerous unique properties-many of which arise and are modulated by the intimate spatial and electronic contact between core and shell. The ligand shell controls the …
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Reciprocity of Effects and Multiple Ligand Interactions on Ligand Bindingto Globular Proteins
Made available in DSpace on 2014-12-10T23:24:36Z (GMT). No. of bitstreams: 1 7514130.pdf: 4061557 bytes, checksum: 31737df743b9f660576fd909b6fb3e07 (MD5) Previous issue date: 1975
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N-Ligand Stabilized Lanthanide Complexes
A series of lanthanide complexes stabilized by N-ligands has been synthesized. Most of these complexes have been structurally characterized. The overall results emphasize the importance of the steric bulk of the applied ligands to stabilize various lanthanide complexes with a distinct reactivity. …
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The Intensity of Ligand Absorption
The ultraviolet absorption spectra of a number of aryl phosphines and amines and transition metal complexes of triphenylphosphine have been determined. These data indicate that the intensity of the Õ* ¬ Õ phenyl ring transition is not only sensitive to the central atom attached to the ring but is …
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Engineering developable miniprotein ligand scaffolds
Binding ligands empower molecular therapeutics and diagnostics, yet discovery of protein ligands is hindered by the vast, sparse, and rugged sequence-function fitness landscape. Protein scaffolds, characterized by a conserved framework to support an engineered variable active site, have proven …
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Ligand-Protein Interactions in Cytochromes
… have shown that at room temperature the ligand is positioned correctly for chemistry. However, how the substrate moves and the correct position of the substrate is not known. In order to gain more insight on the position of the substrate, we conducted solid-state nuclear magnetic …
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Ligand Binding by Heme Proteins
Made available in DSpace on 2014-12-14T04:27:34Z (GMT). No. of bitstreams: 1 7606765.pdf: 4038449 bytes, checksum: 62e351e5367503c1cb5b9b986afaa009 (MD5) Previous issue date: 1975
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Effect of Phosphine Ligand Substitution on the Structures, Reactivities, and Ligand Rearrangements in Organotriosmium Compounds
… and PCy3 0.24 (4) min -1. The more donating ligands have slower rates of polymerization as illustrated by the fact that L = PEt3 and PCy3 have essentially the same rate constant and similar pKa's (8.69 vs. 9.70) but quite different cone angles (132° vs. 162°).
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Triggerable ligand presentation using caged-RGD
… It is unknown whether adhesion to a ligand is required throughout various cell processes, or only during a specified time period ("temporal threshold”). Current approaches to ligand presentation often comprise of static, constant densities of ligands. In contrast, natural cell …
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Ligand and Protein Dynamics of CYP3A4
… our understanding of the linkage between ligand binding and protein conformational dynamics with theoretical considerations of their impact on CYP3A4 catalysis using biophysical and theoretical methodologies. Specifically, the results herein demonstrate the complexity (requiring more than …
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Computational Studies of Autocrine Ligand Binding
Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of …
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Heme protein structure and ligand binding
Binding of carbon monoxide to a variety of heme proteins is a multistep process and can be described by a sequence of activation barriers. In the separated alpha and beta chains of hemoglobin three barriers are found which are sensitive to the structural differences between the two chains. The …
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Gonadotropin releasing hormone receptor ligand interactions
… peptide conformation. To examine how changes in ligand structure cause changes in receptor binding affinity and receptor activation, it was necessary to know the structures of the GnRH receptors. A protocol was developed for the purification of GnRH binding proteins from detergent-solubilized …
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Development and application of quantitative ligand-binding studies to elucidate mechanistic aspects of pentameric ligand-gated ion channels
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Thermodynamics of Ligand Binding to Glutamate Dehydrogenase
… investigation of the mechanism of allosteric ligand binding to GDH. During our computational investigation, we discovered a 40-year-old sequence error at the NADH/ADP/ECG binding site. Residue 387 was mistakenly identified as asparagine rather than the correct amino acid identity, lysine. The …
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Axial Ligand Studies in Iron Triad Metalloporphyrins
Structural studies of iron triad porphyrin carbonyl compounds. A series of pyridine and imidazole iron, ruthenium and osmium complexes are structurally elucidated by x-ray crystallography. These structures have been elucidated for density functional calculations to derive solid state NMR spectra.
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