Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"library design"”.
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The application of classical architectural criteria to 3D digital library design to enhance the learner experience
… and tools. This study proposes combined design principles from human-computer interaction (HCI) and architectural theory, and considers their impact on the user experience.Methodological approach - Literature reviews into HCI and architectural principles in relevant to the design of 3D …
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Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation
… To efficiently target TAR and RRE RNA, we designed and synthesized three generations of branched peptide libraries that resulted in medium sized molecules. The first generation of BPs were discovered from screening a one-bead one-compound library (4,096 compounds) against HIV-1 TAR RNA. One …
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Optimization Algorithms for Protein Bioinformatics
… of this dissertation centers on combinatorial library design, which is a promising protein engineering method. Despite the fact that several mathematical models have been proposed recently and shown great promise, little is known about their theoretic properties. We have discovered several …
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Fantasy Library
… concrete buildings in the city, so do the library, the library in China always design as supremacy of authority, there is no funny and relax atmosphere, it's so hard to get alone with them. I wonder if there has a library can be a garden, I am trying to combine some Chinese classical garden …
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Design and screening of degenerate-codon-based protein ensembles with M13 bacteriophage
… decades, scientists have applied both rational design and directed evolution to accelerate development of high-value proteins, including biotherapeutics. While computational modelling increasingly facilitates protein design, empirically screening large collections of protein variants remains an …
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Circuit level delay and power analysis of graphene nano-ribbon field-effect transistors using monte carlo simulations and standard cell library characterization
… vary together during fabrication. Standard cell library design and characterisation is also explained, which is essential to perform simulations on large circuits that HSPICE is unable to handle. The standard cell library is also constructed and tested on four circuits to validate the library.
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The Ashes and the Portal: An immersive stereoscopic experience on Cyclorama
… stereoscopic animated short capturing the burned library after a fire disaster at Mzuzu University, Malawi, Africa, and it also witnesses the new design of the library from Virginia Tech architecture students. This animated short recreates the burned library and presents the new library design …
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Making Digital Libraries Flexible, Scalable and Reliable: Reengineering the MARIAN System in JAVA
… these problems by enhancing a prototype digital library system with the aim of making it more flexible, scalable, and reliable. We hypothesize that: 1) adding a new (user information) layer and maintaining weak coupling in the design of a digital library system can help achieve system …
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tapestry: towards a newer 'parchitecture, that which is 'pataphysical
How do we design for a local community while respecting heritage and touching their hearts? We know through our minds and we understand through our hearts. Consciousness touches minds and experience touches hearts. Since phenomenology is the study of both consciousness and experience, this …
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Bead Based Peptidyl Libraries for the Selective Recognition of Glycoproteins, Differentiation of Carcinogenic Cell Types, and Determination of Enzyme Substrate Specificity
… patterns will be discussed. Optimization of library design and screening techniques, identification and characterization of selective SLs, and development of an SL array to differentiate carcinogenic cell types and cancer associated glycans will also be highlighted.</p> <p> Along these same …
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Design of protein-protein interaction specificity using computational methods and experimental library screening
Computational design of protein-protein interaction specificity is a powerful tool to examine and expand our understanding about how protein sequence determines interaction specificity. It also has many applications in basic bioscience and biotechnology. One of the major challenges for design is …
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Entropy Based Framework for Static and Dynamic Coverage and Clustering Problems
… to the size of the underlying data, and are designed to avoid local minima. A characteristic feature of the proposed framework is its ability to detect natural clusters in the underlying data, without the need to initialize it a priori. The notion of coverage is first derived in the static …
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Secure Digital Libraries
… that could benefit from a formal approach to design. There are various design aspects to consider in a digital library; a crucial aspect is security. Security often is a requirement in digital libraries that should be considered during the design process and not as an add-on feature. 5S …
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Design, Synthesis And Biological Evaluation Of Small Molecules That Inhibit Hiv-1 Entry And Sensitize Hiv-1 Infected Cells To Immune Responses
… original HTS hit, utilizing parallel synthetic library design, and to define the structure-activity relationships (SAR) observed. Recent crystallographic studies identified the binding site of this new class of CD4mc, which has led to the design of new, more potent analogues.
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The infrastructural space of appearance : the re-formed public library
… -- mass transport lines and the public library. By symbiotically linking the two infrastructures, a space for action and speech emerges that creates concern for the collective object, thereby affirming the reality provided by the public realm. Using Toronto, Ontario as a case study of …
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Ten Thoughts on Architecture
In the face of technological developments, economic demands, and cultural desires that can encourage buildings devoid of character and permanence, we need to look for attributes of architecture that evoke strength and elude the undulations of time.
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Fibronectin domain engineering
… the fibronectin domain. Synthetic combinatorial library design is substantially enhanced through extension of diversity to include three peptide loops with inclusion of loop length diversity. The efficiency of sequence space search is improved by library focusing with tailored diversity for …
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The Automatic Detection of Small Molecule Binding Hotspots on Proteins: Applying Hotspots to Structure-Based Drug Design
… structures and across proteomes, to aid in library design, to assess pockets throughout a molecular dynamics trajectory, to prioritise crystallographic fragment hits and to guide hit-to-lead development.
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Student adoption and perceptions of the library and information mobile services at the University of Namibia
… to examine students' adoption and perceptions of library and information mobile services at the University of Namibia (UNAM), Main Campus. The research objectives were: to assess factors influencing students' adoption and use of wireless technologies that enable them to access library and …
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The Claims Library Capability Maturity Model: Evaluating a Claims Library
… of their projects due to the time required to design and test user interfaces. Unfortunately, there is no "silver bullet" for user interface design and implementation because they are inherently difficult tasks. As computers are moving off the desktop, the greatest challenge for designers will …
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