Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"leukotrienes"”.
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Studies on the effect of cysteinyl leukotrienes on human t cell differentiation and function
… production and mucus hypersecretion. Cysteinyl leukotrienes (CysLTs) are known potent lipid mediators involved in mucus production, bronchoconstriction and leukocyte migration, and act via the receptors CysLTiR and CysLT2R. Recently, CysLTs have been implicated in Th2 responses in mouse models, …
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Die Leukotrienrezeptoren CysLTR1 und CysLTR2 bei Aspirin-Intoleranz
… acid is metabolised by the lipoxygenase to leukotrienes. Leukotrienes are involved in several inflammatory processes. Leukotrienes act on two G protein-coupled receptors, CysLTR 1 and CysLTR 2. There are different starting points in the biosynthesis of the leukotrienes to try to clear the …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… developing alternate host- derived therapies. Leukotrienes (LTs), produced by macrophages and other phagocytic cells including neutrophils, mast cells and dendritic cells during arachidonic acid metabolism, are hypothesized to induce a protective response during cutaneous leishmaniasis. …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… release cytokines and eicosanoids (including leukotrienes, epoxyeicosatrienoic acids, and prostanoids) to activate adaptive immunity. Leukotrienes (LTs), an eicosanoids subset, are produced from arachidonic acid via 5- lipoxygenase metabolism, resulting in LTB4 and cysteinyl LTs (cysLTs; LTC4, …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… (epoxyeicosatreinoic acids, prostanoids and leukotrienes) are generated from metabolites of 20-carbon chained polyunsaturated fatty acids and arachidonic acid. Leukotrienes (LTs) are generated from 5- lipoxygenase-metabolism of arachidonic acid to LTB4 and cysteinyl LTs (cysLTs). CysLTs are …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… release potent mediators, such as histamine, leukotrienes, chemokines and TNF-alpha. The aim of this study was to investigate the role of mast cells in regulating chemokine-provoked tissue infiltration ofleukocytes. It was found that TNF-alpha can activate endothelial cells to express …
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Changes in tear film biochemistry in end of day ocular discomfort with and without contact lenses
… A2, bradykinin, prostaglandins, cysteinyl leukotrienes, resolvin D1, phosphatidylcholines, lysophosphatidylcholines, sphingomyelins, phosphatidylserines, cholesterol esters, triacylglycerides, wax esters and free cholesterols did not change during the day, during CLs wear and they were not …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… in nasal polyp patients showed an increase of leukotrienes and lipoxin A4 in patients with immune response - 18 - against S. aureus enterotoxins, which seem to be correlated to the enterotoxin-derived inflammatory reaction and unrelated to asthma and allergy conditions. These findings were …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… A$\sb2,$ cyclooxygenase or lipoxygenase, leukotrienes (LTs), lysophosphatidyl choline (LPC), lysophosphatidic acid (LPA) and/or prostaglandins (PGs). TGF$\alpha$ stimulated PG secretion in a concentration-dependent manner. This stimulation was suppressed concentration-dependently by …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… risk for developing colon cancer. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 has been …
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
… into hydroperoxy derivatives of PUFAs termed leukotrienes, which play a role in asthma and allergies. The reagent trimethyl silyl diazomethane (TMSD) which is less toxic and explosive than other reagents such as diazomethane, has been developed for use in the methyl esterification of drugs …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer …
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Factors influencing the responsiveness of human bronchi
… sensitive sensory nerves, and the release of leukotrienes.<br/>Evidence is also provided for the relaxant effect of brain natriuretic peptide mainly regulated by the autocrine activity of epithelial cells. Furthermore, the contribution of neutral endopeptidases,<br/>
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Untersuchung der Genexpression von ABC- und SLC-Transmembranproteinen mit Beteiligung am aktiven Transport von Antigenen, Eikosanoiden und Zytostatika beim malignen Melanom
… also of lipid mediators like prostaglandins and leukotrienes. Some MRPs and OATPs show similarities in substrate profiles and function. Coexpression in melanoma is not well known yet, but evidence suggests a coordinate activity of MRP and OATP in vectorial transmembranous substrate transfer. …
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Expression and Regulation of Human Cytochrome P450 4F Isoforms In Tissue Samples and Under Tnf-Alpha Challenges
… metabolize endogenous molecules including leukotrienes, prostaglandins and arachidonic acid. The involvement of these endogenous compounds in inflammation has led to the hypothesis that changes in the inflamed tissue environment may affect the expression of CYP4Fs during the …
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The role of CysLT1R in animal models of colorectal cancer
Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and …
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
BACKGROUND: Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus …
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Influence of oligosaccharides and fish oil on gastrointestinal tract characteristics and metabolic profiles of humans, pigs, and rats
… due to the UCNF compared to the control, while leukotrienes were unaffected. Serum metabolites, hematology, urinalysis, bifidobacteria, and histology were unaffected by treatment. Experiment 3, fifty rats were assigned to one of five diets to examine OS on cecal and colonic short chain FA …
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Treatment of musculoskeletal pain with the sting of the stinging nettle: Urtica dioica
… histamine and serotonin, and also three leukotrienes. Pain theory Areas of possible special relevance to nettle analgesia are the known serotonin and histamine involvement in nociceptor activation, capsaicin substance P depletion and thermal hyperalgesia (possibly similar to nettle …
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Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4
… are still not completely understood. Cysteinyl leukotrienes (CysLTs) play important roles in eosinophilic airway inflammation of AIA via CysLTR1-mediated mechanism. Leukotriene modifier MK-571, a selective CysLTR1 antagonist, is widely used in the management of asthma. We selected Cysteinyl …
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