Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"leukotriene D4"”.
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
BACKGROUND: Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus …
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Involvement of eicosanoid signalling in epithelial cell migration
… through direct stimulation, with the eicosanoid leukotriene D4 (LTD4) or indirectly through inducing cyclooxygenase-2 (COX-2; an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. We observed that direct stimulation with LT D4, induced …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. Remodelling of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… high levels of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis for colon cancer patient. It is therefore of interest to further investigating the effect of LTD4/CysLT1R in tumor progression. The aim of my thesis was to …
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The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
… we investigated the role of eicosanoids – leukotriene D4 (LTD4) or prostaglandin E2 (PGE2) – on CIC properties and changes occurring in the tumor environment that could possibly support CIC-induced tumor growth. To this end, we identified the CICs on the basis of ALDH expression and …
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Polyunsaturated fatty acid requirements of murine colon adenocarcinomas
… The specific 5-LO inhibitor Zileuton and the leukotriene D4 antagonist L-660,711 were less effective inhibitors of MAC cell growth in vitro than the less specific LO inhibitors BWA4C, BWB70C and CV6504. Studies of the hyroxyeicosatetraenoic acids (HETEs) produced from exogenous AA in these …