Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"leukotriene"”.
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Effect of Cysteinyl Leukotriene D4 on Chemokine Expression via Cysteinyl Leukotriene Receptor 1 in Human Lung Epithelial Cells, A549
BACKGROUND: Cysteinyl leukotrienes (CysLTs) such as LTC4, LTD4 and LTE4 are proinflammtory lipid mediators synthesized by the 5-lipoxygenase pathway from arachidonic acid and play important roles in eosinophilic chemotactic activity to airway inflammation characterized by bronchoconstriction, mucus …
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Role of ß-catenin and Leukotriene in Colon Cancer Progression
… high levels of the pro-inflammatory mediator leukotriene D4 (LTD4) in association with its receptor CysLT1 goes with poor prognosis for colon cancer patient. It is therefore of interest to further investigating the effect of LTD4/CysLT1R in tumor progression. The aim of my thesis was to …
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Promoter Polymorphisms of Cysteinyl Leukotriene Receptor 1 (CysLTR1) Influence the Effect of Leukotriene Modifier on Transcriptional Regulation of the CysLTR1 Gene Induced by IL-4
… are still not completely understood. Cysteinyl leukotrienes (CysLTs) play important roles in eosinophilic airway inflammation of AIA via CysLTR1-mediated mechanism. Leukotriene modifier MK-571, a selective CysLTR1 antagonist, is widely used in the management of asthma. We selected Cysteinyl …
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Role of the Leukotriene B4 Metabolic Pathway in Human Pancreatic Cancer
… apoptosis in human pancreatic cancer cells.|Leukotrienes constitute a class of potent biological mediators of inflammation and anaphylaxis. Among them, leukotriene B4(LTB4) is one of the final products of the 5-LOX pathway of arachidonic acid metabolism and it has been widely implicated in …
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Signalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells
… risk for developing colon cancer. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4 are inflammatory mediators that can bind to four known receptors, two of which are the CysLT1R and CysLT2R. Inhibitors of the CysLT1R are currently used in the clinic as asthma medication. LTD4 has been …
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Signaling and regulation of cysteinyl leukotriene receptors in intestinal epithelial cells and colon cancer
… (IBD), increases the risk of cancer. Cysteinyl leukotrienes are pro-inflammatory mediators that are involved in IBD. They are ligands to the G-protein coupled receptors CysLT1R and CysLT2R, of which CysLT1R is associated with poor prognosis and CysLT2R with good prognosis for colorectal cancer …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
Cysteinyl leukotrienes (cysLTs) are potent inflammatory lipid mediators that play a major role in the pathophysiology of inflammatory diseases. They signal primarily through cysteinyl leukotriene receptor-1 (cysLTR1) and have been reported to drive Th2 immune responses. Initiation and amplification …
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Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1
Infection and inflammation are characterized by the release of chemotactic substances that activate cells of the immune system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… (epoxyeicosatreinoic acids, prostanoids and leukotrienes) are generated from metabolites of 20-carbon chained polyunsaturated fatty acids and arachidonic acid. Leukotrienes (LTs) are generated from 5- lipoxygenase-metabolism of arachidonic acid to LTB4 and cysteinyl LTs (cysLTs). CysLTs are …
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Cysteinyl leukotriene receptor 1 as a host determinant for susceptibility to cutaneous leishmaniasis in a mouse model
… developing alternate host- derived therapies. Leukotrienes (LTs), produced by macrophages and other phagocytic cells including neutrophils, mast cells and dendritic cells during arachidonic acid metabolism, are hypothesized to induce a protective response during cutaneous leishmaniasis. …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… release cytokines and eicosanoids (including leukotrienes, epoxyeicosatrienoic acids, and prostanoids) to activate adaptive immunity. Leukotrienes (LTs), an eicosanoids subset, are produced from arachidonic acid via 5- lipoxygenase metabolism, resulting in LTB4 and cysteinyl LTs (cysLTs; LTC4, …
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The Synthesis, Separation, and Identification of Methyl Arachidonate Hydroperoxide Positional Isomers and Their Effect as Components of Large Unilamellar Vesicles on Vesicle Calcium Ion Uptake
… reactions and in prostaglandin and leukotriene production. It has been linked with in vivo aging and peroxides of linoleic and arachidonic acids have been associated with membrane damage.
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The Administration of P2Y12 Antagonist (P113) Attenuates Airway hyperresponsiveness and Airway Inflammation in an Ovalbumin (OVA) Specific Allergic Asthma Model
Backgound and OBJECTIVE: Leukotriene E4 contributes to airway inflammation by interacting with P2Y12 receptor as well as type 1 and 2 cysteinyl leukotriene receptors. We investigated the effects of P113, a P2Y12 receptor antagonist, on airway inflammation in a mouse model of allergic asthma. …
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Dietary Omega-3 Fatty Acids, Cell-Mediated Cytotoxicity and Anti-Tumorigenic Activity in Balb/c Mice
… significantly reduced prostaglandin (PG) and leukotriene production by immune cells. That natural and CMC activity after an immunochallenge was generally not altered by LO feeding was shown in a subsequent study. In this same study it was observed that CMC activity in the spleen 6 days after a …
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cell motility and machine learning
… our model. Another example is the chemotaxis: Leukotriene B4 is secreted as exosomes by neutrophils, serving as a secondary gradient to amplify the chemical attraction of primary chemoattractants. We introduce a model to compare the enhancement effect between directly releasing Leukotriene B4 …
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Einfluss des Leukotrienrezeptorantagonisten Montelukast auf die Chemotaxis eosinophiler Granulozyten durch Endothelzellen
… lassen vermuten, dass durch die PAF-Stimulation Leukotriene aus dem Eosinophilen freigesetzt werden, die autokrin eine Aktivierung dieser Zellen und somit auch eine erhöhte Wanderungsrate herbeiführen. Montelukast könnte hiernach die Aktivierung und damit auch die Transmigration über kompetitive …
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Involvement of eicosanoid signalling in epithelial cell migration
… through direct stimulation, with the eicosanoid leukotriene D4 (LTD4) or indirectly through inducing cyclooxygenase-2 (COX-2; an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. We observed that direct stimulation with LT D4, induced …
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Crosstalk between colorectal cancer cells and tumour-associated macrophages
… cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. Remodelling of extracellular matrix (ECM) occurs in CRC. CD47 binding to α2β1 integrin could …
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