Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"leukoencephalopathy"”.
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Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
… of adult-onset WM disorders. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is an adult-onset, invariably lethal, brain WM disorder with an autosomal dominant inheritance pattern. The clinical symptoms are characterized by a constellation of features that progress to a devastating …
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Möglichkeiten der computertomographischen und magnetresonanztomographischen Bildgebung des zentralen Nervensystems während der Behandlung von akut-lymphoblastischen Leukämien und lymphoblastischen Non-Hodgkin-Lymphomen
… obviously caused by asparaginase, and 6 with leukoencephalopathy caused by intrathecal methotrexate. The clotting problems appeared between the 18th and 40th day of treatment and only in the group of children with first manifestation. The cases with leukoencephalopathy were found between the …
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Neurocognitive outcomes in children experiencing seizures during treatment for acute lymphoblastic leukemia
… more significant early neurotoxicity (i.e., leukoencephalopathy) than non-seizure cohorts. Based on these preliminary findings, it appears that children who experience treatment-related seizures are at greater neurocognitive risk when compared to counterparts who do not. Findings point to a …
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Modelling neuronal mitochondrial aminoacyl-tRNA synthetase defects
… deficiency type 8 (COXPD8), characterised by leukoencephalopathy with ovarian failure, or cardiomyopathy, leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL), and pontocerebellar hypoplasia type 6 (PCH6). Despite their significance, the underlying pathological …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… to the development of progressive multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA …
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A study of the john Cunningham virus (jcv) seroprevalence among Zambian adults presenting with “meningoencephalitis” to the university teaching hospital, Lusaka, Zambia
… to the development of progressive multifocal leukoencephalopathy (PML). Infection with the JCV occurs in childhood and the virus remains quiescent in the body, activating during immunosuppression. Exposure to the virus can be detected by testing for JC virus specific antibodies in an ELISA …
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Unravelling the Genetics of Cerebral Small Vessel Disease
… arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is caused by NOTCH3 variants, and the second most frequent, CADASIL type 2, by autosomal dominant HTRA1 variants. COL4A1/2 variants can cause small vessel stroke and intracerebral haemorrhage. This thesis investigates …
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Cloning of a putative human oncogenic virus, BK
… cells of a patient with progressive multifocal leukoencephalopathy (PML) and was thus the first polyomavirus infection of humans to be discovered. (ZuRhein and Chou, 1965). In 1971, an immunologically distinct polyomavirus, BK, was isolated from the urine of an immunocompromised recipient of a …
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Genetics of Cerebral Small Vessel Disease
… Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL), caused by mutations in the NOTCH3 gene. In recent years, other genes have also been found to cause familial SVD, such as COL4A1/A2, HTRA1, FOXC1 and TREX1. Genome wide association studies (GWAS) have also revealed loci …
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REGULATION OF THE HUMAN NEUROTROPIC POLYOMAVIRUS, JCV, IN THE CENTRAL NERVOUS SYSTEM
… central nervous system, progressive multifocal leukoencephalopathy (PML) that is seen primarily in immunodeficient individuals. Productive infection of JCV occurs only in glial cells and this restriction is to a great extent due to the activation of the viral promoter that has cell type-specific …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… sclerosis (MS) and progressive multifocal leukoencephalopathy (PML). MS is a chronic neuroinflammatory and neurodegenerative disease affecting over two million people worldwide and is a major cause of neurological disability, particularly in young adults. PML is a rare, severe demyelinating …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… demyelinating disorder, Progressive Multifocal Leukoencephalopathy (PML), seen in severely immunocompromised patients. Infection of oligodendrocytes with JCV leads to their lytic destruction and the development of white matter lesions in PML patients. Its main regulatory protein, large tumor …
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Methotrexat-induzierte Leukenzephalopathie bei Patienten mit akuter lymphatischer Leukämie oder lymphoblastischem Non-Hodgkin-Lymphom in Abhängigkeit vom MTHFR-C677T-Status
The antifolate Methotrexate and folate metabolism is central in therapy of pediatric Acute Lymphatic Leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate metabolism, so that combination of MTX-therapy and mutation of the MTHFR gene (MTHFR C677T) might result …