Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"leukocyte adhesion"”.
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Regulation of leukocyte adhesion to endothelium / by Jennifer Ruth Gamble.
… factor [alpha] (TNF-[alpha]) enhances the adhesion of neutrophils to the endothelium by an action both on the neutrophil and on the endothelial cell.
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Effect of IBC isolated from Psoralea corylifolia on expression of adhesion molecule-1 in cerebrovascular endothelial cells
… been implicated in various cerebral diseases. Leukocyte-infiltration into brain parenchyma is critically associated with in the development brain inflammation. Therefore, control of leukocyte infiltration is a very important therapeutic target for the treatment of neurodegenerative diseases …
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Intracellular sphingosine kinase activity as a regulator of endothelial cell inflammatory and angiogenic potential.
… state evidenced by its inability to support leukocyte adhesion and its lack of angiogenesis. I present evidence in this thesis that the intracellular levels and activity of Sphingosine Kinase (SK) regulate the inflammatory potential of the endothelium and are also an important determinant of …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… become activated, promoting the recruitment and adhesion of leukocytes to the vessel wall. This process, involving a complex sequence of leukocyte capture, rolling, and transmigration, contributes to the development of atherosclerotic lesions. Recent research has identified microRNAs as key …
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Plasma membrane calcium ATPase 4 (PMCA4) and inflammation of the aortic endothelium
… relies on the well-coordinated trafficking of leukocytes from the circulation to sites of tissue injury. The endothelial expression of cell adhesion molecules, namely the selectin family, mediates the initial adhesive interactions between leukocytes and the endothelium. Immune cell infiltration …
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The Role of Inflammation in the Early Radiation Response
… necrosis factor alpha (TNF) and intracellular adhesion molecule-1 (ICAM-1) in the radiation response; evaluate the role of a novel anti-inflammatory agent as an interventional therapy to limit the radiation-induced inflammatory response; begin to characterize the acute damage following …
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Comparative effect of haemodynamic variables and rheological properties of the blood on the margination and adhesion of leukocytes and platelets
… blood, had on the behaviour of leukocytes and platelets. By varying shear rate and stress, blood haematocrit, and aggregation and deformability of red cells, we obtained evidence that leukocyte adhesion was dictated by the number of free-flowing cells 'marginated' near the vessel …
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Inflammatory mediators in diabetic retinopathy
… of inflammatory signaling systems and inflow of leukocytes, and ultimately altered gene transcription, in turn promoting the biomolecular DR characteristics. This thesis enlightens how established pathways may contribute to inflammation in DR and summarizes the results of five studies. …
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Ein Knockout-Mausmodell für Congenital Disorder of Glycosylation-IIc: Defizienz des Golgi-GDP-Fucose-Transporters
… Glykoproteine wird durch den CDG-Typ IIc (auch 'Leukocyte Adhesion Deficiency II') deutlich. Aufgrund eines Defektes des Golgi-GDP-Fucose-Transporters (SLC35C1) zeigen die Patienten eine Hypofucosylierung von Glykoproteinen und weisen als klinische Symptome mentale und Wachstumsretardierung, eine …
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On Leukocyte Recruitment in Cholestatic Liver Injury
… liver injury. In this inflammatory process, leukocyte recruitment has emerged as a key feature. Therefore, the aim of this thesis was to analyze the detailed mechanisms behind intrahepatic leukocyte accumulation and its regulation in the pathophysiology of sepsis-associated or obstructive …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… binding to 2GPI and ability to induce leukocyte adhesion molecule expression and IL-8 production in vitro. Two microarray experiments tested differential global gene expression in 6 individual HUVEC donors in response to 5 different PAPS polyclonal anti-2GPI (50 mg/ml) compared to 5 …
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THE EFFECT OF CONFINEMENT ON T-LYMPHOCYTE UPSTREAM MIGRATION UNDER SHEAR FLOW
To maintain homeostasis and fight infections, leukocytes must exit the bloodstream and reach sites of inflammation. The leukocyte adhesion cascade has evolved to perform this function. One step is migration on the endothelium. CD4+ T-lymphocytes migrate upstream on intracellular adhesion molecule-1 …
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On the role of mast cells in chemokine-induced leukocyte recruitment
Leukocyte recruitment is considered to playa key role in numerous inflammatory diseases. Tissue accumulation of Jeukocytes is a multi-steps process comprising rolling, adhesion and transmigration. This process depends on the function of several different cells, including leukocytes, endothelial …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… direct target of aPL, which cause increases in adhesion molecule expression and procoagulant activity. However, the molecular mechanisms underlying aPL actions on endothelium are unknown. Nitric oxide (NO) produced by endothelial NO synthase (eNOS) prevents leukocyte adhesion and thrombosis. In …
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Expression of leukocyte-endothelial adhesion molecules during acute inflammation in the lung
Neutrophil (PMN)-endothelial cell adhesion is a critical step in the response of PMNsto inflammation. In the systemic circulation, the leukocyte adhesion molecule, L-selectin, facilitates PMN adhesion to inflamed endothelium while CD11/CD18 is required for PMN emigration into extravascular tissues. …
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Mechanisms of Brain Edema Formation in Mouse Models of Intracerebral Hemorrhage
… PDGFR-α orchestrated BBB impairment. Vascular adhesion protein-1 (VAP-1) was previously shown to promote leukocyte adhesion and transmigration. Additionally, PDGFR-α was also found to play a role in orchestrating BBB impairment. ICH injury was induced by collagenase-injection (cICH) or …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… reductions in inflammatory events including leukocyte adhesion and migration, and production of inflammatory cytokines. Furthermore HO has been shown to provide neuroprotection and participates to neuronal development in a number of models. We evaluated the role of HO-1 and HO-2 in the …
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Clinical and Biological Aspects of Cardiovascular microRNA
… UTP on cell surface expression of intercellular adhesion molecule 1 (ICAM-1) and leukocyte adhesion is mediated in part by miR-22 in endothelial cells. In conclusion, the levels of circulating cardiac-enriched miRNA have diagnostic and prognostic value in the context of coronary artery disease, …
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Applications of Optical Manipulation for Low Cost Implementation, Beam Shaping and Biophysical Force Measurements
… similar to that found in neutrophils from Leukocyte Adhesion Deficiency sufferers are investigated. Through the use of back focal plane interferometry, a bond rupture force of (17.9 ± 0.6) pN at a force loading rate of (30 ± 4) pN/s, was measured for single integrins expressed on wild type …
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Metabolic regulation of human vascular endothelial cell function in vitro
… vascular health by regulating vascular tone and leukocyte adhesion, amongst others. The vasoregulatory actions of the endothelium are mediated through coordinated release of vasodilators such as nitric oxide (NO) and prostacyclin, and vasoconstrictors such as endothelin-1 and thromboxane A2. …
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