Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"leukemogenesis"”.
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Autophagy in Metabolism, Cell Death, and Leukemogenesis
<p>Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl that promote these processes independent of extrinsic growth factors. …
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WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?
… indicate an oncogenic effector role for WT1 in leukemogenesis.
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The Role of AF9 and AF9-Mediated Protein Interactions in Hematopoiesis and Leukemogenesis
<p>The AF9 protein is one of the most common chromosomal translocation partners of the MLL gene in MLL leukemia. Wild-type AF9 is a member of the pTEFb transcription elongation complex, and interacts with gene regulatory proteins such as AF4/AF5q31, DOT1L, Pc3/CBX8 and BCoR. These interactions are …
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Implications of a CALM-derived Nuclear Export Signal for CALM-AF10-mediated Leukemogenesis
… are perturbed and the precise role of CALM in leukemogenesis have remained unclear. </p><p>In this dissertation, we examine the contribution of CALM to CALM-AF10-mediated leukemogenesis. We determine that CALM contains a functional nuclear export signal (NES) that mediates steady-state …
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Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells
<p>Acute myeloid leukemia (AML) stem cells (LSC) are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed disease. While stem cell transplant serves as proof-of-principle that AML LSCs can be eliminated by the immune system, the translation of existing …
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Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
The t(1;19) chromosomal translocation is present in 5% of acute lymphoblastic leukemia (ALL) cases and leads to expression of the oncogenic transcription factor, E2A-PBX1. Although t(1;19) is exclusively associated with pre-B ALL in clinical cases, murine models produce myeloid or T-lymphoid …
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VDAC1P8 as a Novel Regulatory Element in Leukemogenesis: Integrative Genomic, Epigenetic, and Functional Insights [VDAC1P8 come nuovo elemento regolatorio nella leucemogenesi: approfondimenti genomici, epigenetici e funzionali integrati]
I mitocondri sono organelli essenziali per le cellule eucariotiche, poiché supportano l'enorme richiesta energetica necessaria per mantenere l'omeostasi cellulare. La comunicazione tra il citosol e i mitocondri è mediata dalle porine mitocondriali, note anche come Voltage-Dependent Anion …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… proliferation and survival, may be important in leukemogenesis. Inhibition of Notch signaling by pharmacological and genetic approaches resulted in a loss of serial replating by marrow cells from young non-leukemic mCG-PML-RARA animals. In contrast, colony formation by wildtype marrow is …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… myeloid progenitor cells sufficiently engenders leukemogenesis, plexiform neurofibroma formation depends on LOH in Schwann cells and Nf1 heterozygosity in the hematopoietic system. Specifically, recruited Nf1+/- mast cells accelerate tumorigenesis through secreted cytokines and growth factors. …
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Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
… understanding of molecular underpinnings of leukemogenesis will provide a basis for developing more effective therapeutic strategies for patients with AML.</p> <p>Here, we identified overexpression of hnRNP K as a recurrent abnormality in a subset (~20%) of AML patients. High levels of this …
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Trisomies in Hematologic Malignancies
… chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., trisomies ? are …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
… in the identification of genes implicated in leukemogenesis. The translocation t(12;14)(p13;q11) was shown to result in overexpression of CCND2. The t(12;14) is the first neoplasia-associated translocation shown to result in overexpression of CCND2 and the first example of a targeted …
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Multigradient hydrogels to decode extrinsic regulation of hematopoietic stem cell fate
… notably leukemia stem cell (LSC) mediated leukemogenesis. The niche consists of several components such as the extracellular matrix (ECM), surrounding niche cells and several soluble or ECM-bound factors that influence the HSC fate. Critical as the function of the niche seems, surprisingly …
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Biochemical and Structural Analysis of the Nucleoporin Nup214 and its Involvement in mRNA Export
… a deeper understanding of the role of nups in leukemogenesis, and to make sense of the architecture and regulation of the mRNA export machinery at the NPC, I set out to biochemically and structurally characterize Nup214. In this thesis, I present the crystal structure of the human Nup214 …
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248
… of C/EBPa is regulated both in myelopoiesis and leukemogenesis, is not fully understood. The current study demonstrates that activated Ras enhances the ability of C/EBPa to transactivate the G-CSF receptor promoter and a minimal promoter containing only C/EBP DNA binding sites. Ras signaling …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… mutations in regulators of key cancer genes for leukemogenesis, such as the B-cell lineage specific activator PAX5. These results provide the first supporting evidence that some ncUCEs play important regulatory roles through diverse mechanisms and that analyzing their mutational status in cancer …
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Targeting the protein tyrosine phosphatase, SHP2, and PI3K in FLT3-ITD+ leukemia
… work cooperatively to promote FLT3-ITD-induced leukemogenesis. Consistently, mutation of N51-FLT3 tyrosine 768 to phenylalanine reduced proliferation and levels of phospho-Erk compared to N51-FLT3-expressing cells while having no effect on levels of phospho-STAT5. In transplants, C3H/HeJ mice …
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The Role and Immunogenicity of CBFA2T3-GLIS2 in Pediatric Acute Megakaryoblastic Leukemia
… mechanism by which CBFA2T3-GLIS2 drives leukemogenesis is not well understood. Further, there are currently no studies exploring the immunogenicity of the fusion positive AMKL cells and immunotherapeutic approaches are lacking. To address these knowledge gaps, I developed two mouse models …
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MICROGRAVITY NEGATIVELY AFFECTS DNA DAMAGE REPAIR AND THE ANTI-LEUKEMIC FUNCTION OF HUMAN NATURAL KILLER CELLS
… function/differentiative capacity, and triggers leukemogenesis when these cells repopulate murine hosts. Importantly, astronaut on missions beyond low-Earth orbit are exposed to these unique high-energy species of radiation while in conditions of microgravity (G), which can alter radiation …
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… shown to cooperate with <em>BCR-ABL1</em> during leukemogenesis. Furthermore, as seen in human ALL, both <em>Pax5</em> and <em>p19Arf</em> haploinsufficiency further cooperate during leukemogenesis. Pathological analysis of the leukemias revealed a B-lymphoid phenotype suggesting that this model …
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