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Showing 1 to 6 of 6 for “"leukemia stem cells"”.

  1. Immunogenicity of leukemia stem cells in acute myeloid leukemia

    Zhang, LuUniversität Ulm

    ulm-diss Repository record

  2. Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells

    Herbrich, Shelley, <p>0000-0002-3825-6752</p>2021

    <p>Acute myeloid leukemia (AML) stem cells (LSC) are capable of surviving current standard chemotherapy and are the likely source of deadly, relapsed disease. While stem cell transplant serves as proof-of-principle that AML LSCs can be eliminated by the immune system, the translation of existing …

    uthsc Repository record

  3. Eliminating Acute Myeloid Leukemia Stem Cells by Targeting the Niche Microenviromnent: Co-Inhibition of TNF/IL1- JNK and NF-κb

    Volk, Andrew2016

    <p>Leukemia Stem Cells (LSCs) from Acute Myeloid Leukemia (AML) require the activity of the transcription factor NF-kB to maintain stemness and drive tumor formation. Blocking NF-kB can preferentially eliminate LSCs in vitro with minimal effects on healthy Hematopoietic Stem and Progenitor Cells …

    loyola-thes Repository record

  4. Persistant GATA2 Expression Promotes Self-Renewal of Myeloid Progenitors and Blocks Lymphoid Differentiation.

    Nandakumar, Satish Kumar2016

    … GATA2 is highly expressed in hematopoietic stem cells (HSCs) and is downregulated during differentiation. Overexpression of GATA2 is frequently observed in acute myeloid leukemia. In previous studies, enforced expression of GATA2 using a MSCV GATA2 retroviral vector blocked differentiation …

    tenn-hsc Repository record

  5. Synthesis of anticancer agents: 15-deoxy-15-fluoro-Δ12-prostaglandin J3 and gukulenin monomeric units

    Yu, RuochengRice University2017

    … in the in vitro and in vivo eradication of leukemia stem cells (LSC). This anti-LSC potency of Δ12-PGJ3 might represent a new solution in combating cancer recurrence, and therefore warrants systematic investigation into its structure–activity relationship (SAR). Thus, in Chapter 1, we …

    rice Repository record

  6. Role of Polycomb Group Protein Mel18 in Hematopoietic Stem Cell Maintenance

    Cai, Wenjie2025

    … gene silencers that have been implicated in stem cell maintenance and cancer development. Genetic and biochemical studies indicate that Polycomb group proteins exist in at least two protein complexes, Polycomb repressive complex 2 (PRC2) and Polycomb repressive complex 1 (PRC1). PRC2 complex …

    iupui Repository record