Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"leukemia relapse"”.
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… changes that underlie B-cell acute lymphoblastic leukemia relapse. I found recurrent loss of DNA methylation in patient-matched relapse samples that indicate a more stem-like chromatin state. Together, my work investigates the relationship between multiple components of the chromatin architecture, …
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Donor lymphocyte infusion after allogeneic stem cell transplantation in children
… (DLI) is an important curative therapy for relapse or persistence of hematologic malignancy and bone marrow failure syndrome following allogeneic hematopoietic stem cell transplantation (allo HSCT). However, DLI is limited by the development of graft-versus-host disease (GVHD)and marrow …
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Combining mechanistic modelling with data-driven modelling in mathematical oncology
… 3 and 4, we study the acute lymphoblastic leukemia relapse problem. We investigate the dynamics of residual disease in individual patients to mathematically model leukemia evolution in observed response and relapse kinetics. We developed stochastic and deterministic, patient-specific models …
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Genetic Polymorphisms and the Treatment Outcome in Standard-Risk Pediatric Acute Lymphoblastic Leukemia
<p>Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and accounts for 30 - 35% of all cancers in children. Significant improvement in the treatment of pediatric ALL has been achieved in recent years. Only 50 years ago, the disease was uniformly fatal with an Overall Survival …
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IKAROS and LEUKEMIA
Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct …