Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"leukemia models"”.
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Two investigations in molecular pathophysiology
… the cells of a murine model of auto-stimulatory leukemia. Although many previous workers have examined the ability of growth-factor antagonists to inhibit the growth of the cells of human leukemias and of animal leukemia models, none have documented the complete blockage of growth, and none have …
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Oxidative Stress Based Strategies For Enhancing The Efficacy of Histone Deacetylase Inhibitors (Hdaci)
… this hypothesis, we treated acute lymphocytic leukemia cells (ALL) with HDACi and adaphostin (ROS generating agent). The combination of two different HDACi (vorinostat or entinostat) with adaphostin synergistically induced apoptosis in ALL. This synergistic effect was blocked when cells were …
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Functional Modeling of Genes Upregulated in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is caused by the transformation of a primitive hematopoietic cell by the BCR/ABL1 fusion gene that is formed through the chromosomal translocation t(9;22). CML is currently successfully treated with tyrosine kinase inhibitors targeting the ABL1 kinase domain. However, …