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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 64 for “"leucine-rich repeat"”.

  1. Functions of small leucine-rich repeat proteoglycans in connective tissues

    Kalamajski, SebastianDepartment of Experimental Medical Science, Lund Univeristy2008

    … matrix assembly, the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and influence its fibril formation. In this manner, fibromodulin - one of the SLRPs - can alter intermolecular cross-linking of collagen, which has long-term implications for the …

    lund Repository record

  2. α-Synuclein and Leucine Rich Repeat Kinase 2 (LRRK2) Interaction During Axonal Transport

    Chakraborty, Piyali; 0000-0003-0862-3280State University of New York at Buffalo2025

    M.S.

    buffalo Repository record

  3. Das "Leucine-Rich Repeat" im Invasionsprotein Internalin B : Stabilität und Faltung eines Solenoidproteins

    Freiberg, AlexanderUniversität Potsdam

    … der solenoiden Proteine, zu denen z. B. Leucine-Rich Repeat- (LRR-) oder Ankyrin-Proteine gehören, wurde dahingegen noch wenig untersucht. Die Proteine dieser Klasse sind durch einen stapelförmigen Aufbau von sich wiederholenden typischen Sequenzeinheiten gekennzeichnet, was in der …

    potsdam-diss Repository record

  4. Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system

    Levy, Daniel Robert SiegfriedUniversity of Cambridge2018

    Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 …

    cambridge Repository record

  5. LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE

    DULE, NEVIAUniversità degli Studi di Milano2024

    Leucine-Rich Repeat Kinase 2 (LRRK2) is a large protein encompassing multiple functional domains, including kinase and GTPase enzymatic activity and several protein-protein interaction modules. It is expressed in the central nervous system (CNS) and it is among the most important genetic risk …

    milano Repository record

  6. Estradiol Regulation of Leucine-Rich Repeat Immunoglobulinlike Domains Protein 1 (Lrig 1) and Roles of Estrogen Receptor in Translational Regulation in Breast Cancer Cells

    Funk, Cory C.University of Illinois at Urbana-Champaign2015

    … the principle actions of estradiol. We identify leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) as an estradiol-regulated gene. LRIG1 is a negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen …

    uiuc Repository record

  7. Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells

    Funk, Cory C.University of Illinois at Urbana-Champaign2011

    … the principle actions of estradiol. We identify leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) as an estradiol-regulated gene. LRIG1 is a negative regulator of Receptor Tyrosine Kinase (RTK) signaling. Up-regulation of LRIG1 mRNA and protein is mediated by the estrogen …

    uiuc Repository record

  8. Building a Consistent Neuronetwork: Defining Molecular Cues Involved in the Synaptic Target Recognition of Drosophila Melanogaster

    Rose, Demian DanaUniversity of Illinois at Urbana-Champaign2015

    … synaptic target recognition, while Toll, a leucine-rich repeat molecule, prevents the process. The effects of each protein, which are functionally disparate, can be summated by individual growth cones based upon the relative amounts of either cue present to arrive at a net synaptic decision. …

    uiuc Repository record

  9. The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm

    Yang, Jiah, <p>0000-0003-2312-8536</p>2019

    … controlling circadian rhythms. F-Box and Leucine Rich Repeat Protein21 (FBXL21) is a circadian E3 ligase which shows oscillatory mRNA transcripts and protein levels. It was previously found to perform subcellular compartment-specific E3 ligase activities targeting the core clock proteins …

    uthsc Repository record

  10. Fine Mapping and Candidate Gene Discovery at the Rsv3 Locus

    Bowman, Brian CarterVirginia Tech2011

    … containing four coiled-coil nucleotide-binding leucine-rich repeat proteins. In a related study a large population segregating at the Rsv3 locus was screened for resistance to facilitate future characterization of this region. The markers identified in this study will allow for more accurate …

    vt Repository record

  11. A clinical and molecular genetic study into familial and sporadic Parkinson’s Disease

    Lewthwaite, Alistair JohnUniversity of Birmingham2009

    … role of a recently identified hereditary PD gene leucine rich repeat kinase 2 (LRRK2) in PD in the United Kingdom (UK). In this thesis I have confirmed the importance of pathogenic LRRK2 mutations in UK familial PD (fPD). In addition I identified three novel frameshift mutations. I investigated …

    birmingham Repository record

  12. Characterization of 16B09 and 2D01 effector proteins in cyst nematodes

    Lin, MarriamUniversity of Missouri--Columbia2016

    … 2D01 was carried out and HAE, an Arabidopsis leucine-rich repeat receptor kinase that controls floral organ abscission and lateral root emergence, and is expressed in the nematode feeding cell, was identified as a potential host target of this effector.

    missouri Repository record

  13. Mechanisms underlying retinogeniculate synapse formation in mouse visual thalamus

    Monavarfeshani, AboozarVirginia Tech2018

    … time points during RG synapses development. Leucine-Rich Repeat Transmembrane Neuronal 1 (LRRTM1), a synaptogenic adhesion molecule, was the candidate I selected based on its expression pattern. Here, I discovered that LRRTM1 regulates the development of complex RG synapses. Mice lacking …

    vt Repository record

  14. Protein Engineering for Biomedical Materials

    Parker, Rachael N.Virginia Tech2017

    … three and four discuss the engineering of repeat proteins as bio-recognition modules for biomedical sensing and imaging. Chapter three provides an overview of the most recent advances in engineering of repeat proteins in the aforementioned field. Chapter four discusses my contribution to …

    vt Repository record

  15. Identification and Classification of Novel Gene Products Involved in Development and Regeneration in Xenopus Laevis

    Wolfe, Adam DanielUniversity of Illinois at Urbana-Champaign2015

    … of these genes is a novel member of the neuronal leucine-rich repeat protein family. Protein knock down assays have shown that this protein acts autonomously during differentiation of lens fiber cells and cells of the neural retina. Through elucidating our understanding of molecular mechanisms …

    uiuc Repository record

  16. The genetic and developmental bases of male genital organ size evolution

    Hagen, Joanna Frances DonnellyOxford Brookes University2019

    … size evolution between these species. Trn is a Leucine Rich Repeat transmembrane protein, and is the first gene identified underlying genital organ size differences between species. Moreover, expression analysis of trn implies cis-regulatory evolution, and likely candidate trn enhancer has been …

    oxford-brookes Repository record

  17. A NOVEL RIT2-LRRK2 AXIS MODULATES LYSOSOME FUNCTION: INSIGHT FOR PARKINSON'S DISEASE PATHOPHYSIOLOGY

    PIZZI, SARAUniversità degli Studi di Milano2023

    … di Parkinson (PD). L’attività chinasica di Leucine-rich repeat kinase 2 (LRRK2) modula autofagia e funzionalità lisosomiale, e la sua inibizione farmacologica è protettiva per neurodegenerazione e patologia di α-sinucleina (αSyn). Tuttavia, rimane da chiarire la via di segnalazione che …

    milano Repository record

  18. Approaches towards disease resistance to filamentous pathogens

    Giannakopoulou, ArtemisUniversity of East Anglia2015

    … immune receptors of the Nucleotidebinding Leucine-rich Repeat-containing protein family (NLRs). NLRs typically recognize pathogen effector proteins with avirulence activities, leading to a response known as effector-triggered immunity (ETI). R3a and I2 are orthologous NLRs from potato and …

    east-anglia Repository record

  19. The dynamics of molecular components that regulate aphid-plant interactions

    Drurey, ClaireUniversity of East Anglia2015

    … perception of aphid elicitors requires the Leucine-Rich Repeat Receptor- Like Kinase (LRR-RLK) BAK1, which is required for multiple PTI responses via interaction with other RLKs. I identified two RLKs which may detect aphid elicitors and provide specificity to aphid detection. Successful …

    east-anglia Repository record

  20. Dissecting the role of plant immunity in plant-aphid interactions

    Prince, DavidUniversity of East Anglia2012

    … of a 3 to 10 kDa elicitor fraction requires the leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1, as a mutant in this gene was deficient in immune responses activated by this elicitor. Plant recognition of the elicitor is unlikely to depend on a single non-arginine-asparate (non-RD) RLK. …

    east-anglia Repository record

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