Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"leucine zipper"”.
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Identifikation einer funktionellen Kernerkennungssequenz in der Dual-Leucine-Zipper-Bearing Kinase
Es existieren viele Hinweise darauf, dass proinflammatorische Zytokine wie z.B. TNF-α und IL-1β an dem Verlust der funktionellen Beta-Zellmasse im prädiabetischen Zustand beteiligt sind. Sie führen dabei zur Aktivierung des MAP-Kinase-Wegs unter Einbeziehung von JNK, was zu einer gesteigerten …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… function, morphology, and survival. Dual Leucine Zipper Kinase (DLK) modulates neuronal stress responses, including neuronal loss implicated in various neurodegenerative conditions. DLK is axonally expressed and is under constant suppression under normal conditions. Although DLK is known …
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The Arabidopsis C/S1 bacic leucine Zipper transcription factor network:Impact of heterodimer formation on target gene transcription
Die Heterodimerisierung der basic leucine zipper (bZIP) Transkriptionsfaktoren (TFs) spielt eine wichtige Rolle bei der Regulierung der Genexpression. Zur Analyse der Heterodimerisierung der Arabidopsis thaliana (At) bZIP-Faktoren wurde ein Gateway® basierendes two-hybrid System in pflanzlichen …
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Wirkung der proinflammatorischen Zytokine TNFα und IL-1β auf die Aktivität und die Proteinmenge der Dual-Leucine-Zipper-Bearing Kinase in einer Betazelllinie
Beim Diabetes mellitus Typ 2 kommt es durch eine Dysbalance von Replikation und Apoptose der pankreatischen Betazellen sowie durch eine periphere Insulinresistenz zu einer gestörten Glukosehomöostase. Die proinflammatorischen Zytokine TNFα und IL-1β sind dabei wichtige pathogene Effektoren, wobei …
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The Effects of RHAMM on Cell Division, Cell Motility, and Tumorigenesis
… mitotic spindle and centrosomes via a C-terminal leucine zipper; these interactions are predicted to regulate genomic stability and cell polarity and proposed to account for the oncogenic function of RHAMMΔ163. We hypothesized that RHAMM leucine zipper maintains mitotic spindle integrity and …
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MOLECULAR CHARACTERIZATION OF THE PUTATIVE NUCLEOTIDE- BINDING AND HYDROLYZING ACTIVITIES OF THE ELLIS VAN CREVELD (EVC) PROTEIN
… motifs in EVC sequences including P-loop, leucine zipper, transmembrane domain, and nuclear localization signal. The putative nucleotide-binding and hydrolyzing activities of EVC were tested using fragments of the protein from mice and human that contain the P-loop and leucine zipper …
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Characterization of the Paraneoplastic Cerebellar Degeneration Antigen Cdr2
… cdr2, which encodes a cytoplasmic coiled-coil leucine zipper protein, is the only cdr gene expressed in PCD-associated tumors, and is therefore the true PCD tumor antigen. We have isolated the mouse cdr2 homologue and examined expression of the mRNA and protein in adult tissues. The cdr2 …
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Cloning and characterisation of a bZIP transcription factor from a resurrection grass, Eragrostis nindensis
… light as well as by abscisic acid (ABA). Basic leucine zipper (bZIP) transcription factors have been shown to specifically bind and activate transcription from G-boxes in a dimerized form. A 1.5 kb cDNA for a bZIP class transcription factor, designated EnGBF1, was cloned from a …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
… that are characterized by a basic region and a leucine zipper domain. While many AP-1 proteins also contain defined transcriptional activation domains: TADs), some consist only of a basic region and leucine zipper and are thought to function as inhibitors of AP-1 activity. We found that the AP-1 …
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DNA Recognition by Helix-Loop-Helix Proteins
… a heptad repeat of hydrophobic amino acids, or "leucine zipper" (Z). My X-ray crystallographic structure determination at 2.9Å resolution of a dimer of the b/HLH/Z domain of the mammalian oncoprotein Max bound to its target DNA revealed that this symmetric homodimer folds into a novel parallel …
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Subunit Interactions of Recombinant HIV-1 Reverse Transcriptase With Mutations at L289
… binding of RT occurs, mutations were made at leucine (L) 289, a residue believed to be involved in dimerization through hydrophobic interactions with other leucines. L289 is the central leucine of a leucine repeat sequence which resembles a leucine zipper protein-DNA binding motif. Two …
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Regulation of GmHD-ZIPIII During Soybean Root Lateral Organ Development
… are being identified. Class III homeodomain leucine zipper (HDZIPIII) proteins are a group of plant specific transcriptional factors that are known to regulate several developmental process in Arabidopsis and other plants. Transcriptional, post-transcriptional and post-translational …
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Translational Regulation of the C-Jun Proto-Oncogene
… Fra2), or with CREB family members through the leucine zipper motif. Because the <em>c-jun</em> proto-oncogene plays an important role in cell transformation, extensive work has been done to understand how it is regulated. Previously, it has been shown that c-jun transcription can be activated …
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Modular design of coiled coils to target bZIP transcription factors
Basic leucine-zipper (bZIP) transcription factors regulate many important cellular processes including tissue differentiation, stress responses and the unfolded protein response, the cell cycle, and apoptosis. Understanding the genes and processes regulated by bZIPs is imperative for understanding …
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The construction and testing of maize transcriptional fusions in yeast (Saccharomyces cerevisiae)
… 02 encodes a protein containing a basic leucine zipper domain
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C/EBPalpha downregualtes c-jun expression
… C/EBPa. C/EBPa and c-jun interact through their leucine zipper domains and this interaction prevents c-jun from binding to DNA. This results in downregulation of c-jun’s capacity to autoregulate its own promoter through the proximal AP-1 site. Overexpression of c-jun prevents C/EBPa induced …
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Discovery and characterization of a small molecule that modulates c-Myc mediated transcription via max homodimer stabilization
… factor Myc is a basic helix-loop-helix leucine zipper (bHLHLZ) protein with crucial roles in regulating normal cellular processes, but its transcriptional activity is deregulated in a majority of human cancers. Myc transcriptional activity is dependent on dimerization with its obligate …
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Expanding the Spiroligomers Toolbox as Protein-Protein Interaction Inhibitors
… spiroligomers that mimic the side chains of the leucine zipper region of Max were synthesized in an effort to disrupt the interaction of the protein with c-Myc. The series of compounds contained various stereocenter combinations and different functional groups as before but were made in solution …
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Modulation of Nocturnin Phosphatase Activity through the Disordered Amino Terminus
… from NADP(H). High sequence conservation of the leucine zipper (LZ)-like motif, the only structural element in the amino terminus, highlights the potential importance of this domain in modulating phosphatase activity. I use in vitro biochemical and biophysical techniques to demonstrate that the …
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Applying engineering principles to the design and construction of transcriptional devices
… from a zinc finger DNA binding domain and a leucine zipper dimerization domain. Zinc fingers and leucine zippers offer a potential scalable solution to the challenge of building libraries of transcription-based logic devices for arbitrary information processing in cells.
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