Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 428 for “"leucine"”.
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Functions of small leucine-rich repeat proteoglycans in connective tissues
… matrix assembly, the cells secrete small leucine-rich repeat proteoglycans (SLRPs) that bind to collagen and influence its fibril formation. In this manner, fibromodulin - one of the SLRPs - can alter intermolecular cross-linking of collagen, which has long-term implications for the …
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Identifikation einer funktionellen Kernerkennungssequenz in der Dual-Leucine-Zipper-Bearing Kinase
Es existieren viele Hinweise darauf, dass proinflammatorische Zytokine wie z.B. TNF-α und IL-1β an dem Verlust der funktionellen Beta-Zellmasse im prädiabetischen Zustand beteiligt sind. Sie führen dabei zur Aktivierung des MAP-Kinase-Wegs unter Einbeziehung von JNK, was zu einer gesteigerten …
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Leucine and exercise improve skeletal muscle function in the mdx mouse
… and exercise therapies. We hypothesized that leucine, a branched chain amino acid (BCAA) with anabolic properties, given to sedentary and exercised x-linked dystrophic mice (mdx) over 4 weeks would improve skeletal muscle function and decrease markers of skeletal muscle degradation. In …
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Das "Leucine-Rich Repeat" im Invasionsprotein Internalin B : Stabilität und Faltung eines Solenoidproteins
… der solenoiden Proteine, zu denen z. B. Leucine-Rich Repeat- (LRR-) oder Ankyrin-Proteine gehören, wurde dahingegen noch wenig untersucht. Die Proteine dieser Klasse sind durch einen stapelförmigen Aufbau von sich wiederholenden typischen Sequenzeinheiten gekennzeichnet, was in der …
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The Effects of Exercise and Dietary Protein on Leucine Oxidation in Laboratory Rats
… of the essential branched-chain amino acid, leucine (leu), increases in response to exercise. The purpose of this thesis was to investigate the effects of exercise and dietary protein on leu metabolism by measuring in vivo leu oxidation (leu ox) and in vitro branched-chain alpha-keto acid …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… function, morphology, and survival. Dual Leucine Zipper Kinase (DLK) modulates neuronal stress responses, including neuronal loss implicated in various neurodegenerative conditions. DLK is axonally expressed and is under constant suppression under normal conditions. Although DLK is known …
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Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
Leucine rich repeat kinase 2 (LRRK2) is a 286 kDa protein expressed in a variety of tissues and cell types, including neuronal tissue and innate immune cells. Mutations in LRRK2 have been linked to inflammatory diseases, most notably Crohn’s disease and Parkinson’s disease. Further to this, LRRK2 …
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Effects of Leucine on Skeletal Muscle During 14 d Bed Rest in Middle-aged Adults
… acutely ill patients. The essential amino acid leucine has been shown to acutely stimulate muscle protein synthesis (MPS), a decrease in which mechanistically drives inactivity-induced losses in muscle. This study evaluated the effects of leucine supplementation (0.06 g • kg • meal-1; LEU) with …
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In Vitro and In Vivo Effects of Leucine on Skeletal Muscle Protein Synthesis and Degradation
The regulatory role of leucine in skeletal muscle protein synthesis and degradation was examined using in vitro and in vivo experimental methods. Two skeletal muscles from young Sprague-Dawley rats were used in all experiments. These muscles were the soleus, a slow-twitch, oxidative muscle and the …
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The effect of leucine and dileucine ingestion on muscle protein turnover in healthy young men
… to optimize skeletal muscle mass and health. The leucine content of a meal is believed to be an important anabolic characteristic of a meal. Specifically, leucine is a potent amino acid that serves both as an anabolic signaling molecule and substrate to potentiate MPS. Beyond single amino acids, …
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LEUCINE-RICH REPEAT KINASE 2 (LRRK2) AT THE CROSSROAD OF INSULIN SIGNALLING AND PARKINSON S DISEASE
Leucine-Rich Repeat Kinase 2 (LRRK2) is a large protein encompassing multiple functional domains, including kinase and GTPase enzymatic activity and several protein-protein interaction modules. It is expressed in the central nervous system (CNS) and it is among the most important genetic risk …
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Phenotypic Analysis of the Regulatory Role of the Leucine-Responsive Regulatory Protein (LrpPA) in Pseudomonas aeruginosa
… to select new targets for therapy. The leucine- responsive regulatory protein (Lrp) could be a promising target for treatment. The ortholog in <em>Escherichia coli</em> is a global regulator of metabolism and regulates many genes related to amino acid degradation, transport and …
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The Role of Leucine and Its Metabolite (KIC) in Insulin Signalling and Glucose Transport in L6 Myotubes
… However, elevated levels of BCAAs (particularly leucine) and their metabolites have also been implicated in the development of insulin resistance and type 2 diabetes mellitus (T2DM). This study examines the dose-dependent effect of leucine in the presence or absence of other amino acids on …
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The acute effects of l-Leucine and l-Isoleucine on glycemic responses in healthy and inactive adults
… the “priming” effect of pre-ingested L-Isoleucine (ISO) and L-Leucine (LEU) on glucose metabolism and glycemic hormones in healthy, inactive adults. We hypothesized that preingested ISO and LEU would diminish the post prandial rise in glucose prior to a 75 g oral glucose tolerance test …
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The Arabidopsis C/S1 bacic leucine Zipper transcription factor network:Impact of heterodimer formation on target gene transcription
Die Heterodimerisierung der basic leucine zipper (bZIP) Transkriptionsfaktoren (TFs) spielt eine wichtige Rolle bei der Regulierung der Genexpression. Zur Analyse der Heterodimerisierung der Arabidopsis thaliana (At) bZIP-Faktoren wurde ein Gateway® basierendes two-hybrid System in pflanzlichen …
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Escherichia coli mutants unable to use a combination of L-serine, glycine and L-leucine as carbon source
… a combination of L-serine, glycine and L-leucine (SGL medium) has been used to study the characteristics, including the activation system, of L-serine deaminase (L-SD), an interesting enzyme from Escherichia coli that is first synthesized in an inactive form. In this thesis, I isolated two …
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The formation of isovaleraldehyde from ℓ-leucine and isobutyraldehyde from ℓ-valine catalyzed by banana polyphenoloxidase and peroxidase
… for the formation of isovaleraldehyde from l-leucine and isobutyraldehyde from l-valine in bananas are described. These aldehydes are key intermediates for the development of the branched-chain alcohols and esters, which are prominent components of banana flavor volatiles. When amino acids …
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Impact of Leucine and HMB on Acute Muscle Damage: Focus on Repair and Regeneration in vivo and in vitro
… of the satellite cell. Interventions including leucine and HMB supplementation are consumed with the aim of improving muscle mass. Currently, there is a lack of understanding around muscle repair and regeneration from injury and specifically, the influence of cellular ageing. In addition, the …
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