Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"letrozole"”.
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Συνδυασμός λετροζόλης και κιτρικής κλομιαφαίνης έναντι λετροζόλης στην πρόκληση ωορρηξίας σε γυναίκες με σύνδρομο πολυκυστικών ωοθηκών (PCOS): Συστηματική ανασκόπηση και μετά-ανάλυση / Combination of letrozole and clomiphene citrate versus letrozole monotherapy in inducing ovulation in women with polycystic ovary syndrome (PCOS): A systematic review and meta-analysis
Υπόβαθρο: Το σύνδρομο πολυκυστικών ωοθηκών είναι μια διαταραχή που επηρεάζει το 4-20% των γυναικών αναπαραγωγικής ηλικίας και χαρακτηρίζεται από ανωορρηξία, υπερανδρογονισμό και μεταβολικές διαταραχές. Η πρόκληση ωορρηξίας αποτελεί βασικό στοιχείο της αντιμετώπισης της υπογονιμότητας σε γυναίκες με …
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Comprehensive gene assessment of estrogen receptor positive breast cancers reveals that HER2 positive status plays an important role in resistance to neoadjuvant letrozole
… decision making, who will respond to neoadjuvant letrozole therapy and who might benefit from the addition of combined HER2 targeted agents. Aims 1. To investigate which ER positive/ HER2 positive breast cancers respond to letrozole. 2. To compare the mechanisms of resistance to endocrine therapy …
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Changes of breast cancer growth and metastasis in murine models modulated by an aromatase inhibitor, a low calcium diet or a high fat diet
… of this study is that the aromatase inhibitor letrozole may inhibit BC metastases to lungs by suppressing estrogen synthesis. BC growth on the bone micro-metastatic site and lung metastases were monitored in live animals via Bioluminescence Imaging (BLI). Effects of ovariectomy and letrozole on …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
… used to evaluate the effect of treatment with letrozole, everolimus, and metformin <em>in vivo</em>. These studies demonstrated that tumors with an activating KRas mutation are resistant to treatment with letrozole even in combination with everolimus. Tumor growth and cellular proliferation …
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Cytoplasmic Cyclin E Mediates Resistance to Aromatase Inhibitors In Breast Cancer
… with LMW-E expression are unresponsive to letrozole. Using LMW-E inducible model system, we show that LMW-E expression bypasses cell cycle inhibition of AIs through up-regulation of CDK2, Rb, and phospho-Rb in a reversible manner. Lastly, we show that LMW-E expressing breast cancer cells …
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The RESILIENT Study: A Retrospective, Descriptive, Correlational Investigation of Rate and Correlates of Oral Endocrine Therapy Adherence in Older Women with Breast Cancer
… endocrine therapy (OET), such as anastrozole, letrozole, tamoxifen, and exmestane. These medications increase survival, improve quality-of-life and decrease healthcare costs, yet many patients do not take it properly. The purpose of this study is to identify rates of and multi-level …
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Tracing Androgen Metabolism With Inhibition Of Aromatase In Breast Cancer: In Vitro Studies And Clinical Correlates
… demonstrated that among the third generation AI, letrozole has the greatest efficacy for suppressing estradiol and estrone formation from testosterone and Δ4-androstendione in vitro. Biological response and metabolism of the circulating steroid precursor dehydroepiandrosterone (DHEA) and its …
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Estrogen signaling during decidualization
… obtained from mice treated with or without letrozole, a specific inhibitor to the key biosynthetic enzyme, cytochrome P450 aromatase. Of the number of molecules identified from the microarray analysis likely to be involved in cell differentiation, the c-Fos family member Fos related …
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The Use of Oncology Electronic Health Record Databases to Assess the Effectiveness of Breast Cancer Treatment
… of time-to-next-treatment (TTNT) in palbociclib-letrozole users versus letrozole-only users. TTNT was chosen as an endpoint because it was well-observed in the EHR database and appeared to serve as a meaningful surrogate for treatment effectiveness in the PALOMA-2 trial. All eligibility criteria, …
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Steroid hormone regulation of fetal mouse oocyte development
… action, we used aromatase and 3βHSD inhibitors (letrozole and trilostane respectively) in organ culture to block hormone production by fetal ovaries. We find that the total number of oocytes was reduced in treated ovaries compared to controls. The second objective of the dissertation was to …
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The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
… We have shown that by treating animals with letrozole, an aromatase inhibitor, that ovarian tumor volume is decreased compared to untreated animals, indicating a novel role of ERalpha in ovarian tumorigenesis. This animal model mimics the genetic profile of human serous epithelial ovarian …
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Understanding female social dominance: comparative behavioral endocrinology in the Genus Eulemur
<p>Female social dominance over males is unusual in mammals, yet characterizes most Malagasy lemurs, which represent almost 30% of all primates. Despite its prevalence in this suborder, both the evolutionary trajectory and proximate mechanism of female dominance remain unclear. Potentially …