Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 363 for “"lethality"”.
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Methodology to Perform Cyber Lethality Assessment
… Warfare Center, Dahlgren Division (NSWCDD) Lethality and Effectiveness Branch is the Navy’s subject matter experts (SME) on target vulnerability, weapon lethality, and weapon effectiveness. Branch personnel currently exercise expertise in the kinetic and directed energy weapon domains. When …
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Targeting Telomerase Overexpression by Synthetic Dosage Lethality
… Genetic interactions, such as synthetic dosage lethality can overcome these issues and identify targets that is specific only tumor cells that overexpress telomerase. We used a combination of pooled shRNA and CRISPR screening platforms to comprehensively query the entire human genome and …
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Assessing violent encounters: police use of lethality reporting
… victimization, police agencies have begun to use lethality assessments. This strategy involves the use of screening questions asked of victims that assess dangerousness. Grounded in the criminological literature on domestic violence (DV), the Maryland Lethality Assessment Protocol (LAP) has been …
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IDENTIFYING AND EXPLOITING SYNTHETIC LETHALITY FOR CANCER THERAPEUTICS
Synthetic Lethality (SL) is considered a promising approach for the development of personalized treatments. However, SL interactions in humans remain largely unknown and there is a need to discover more such pairs, especially those that are clinically actionable, and to develop tools that can …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein …
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The synthetic dosage lethality between hTERT and DNA damage response associated genes
… hTERT, this project uses synthetic dosage lethality (SDL) to indirectly inhibit its activity. SDL occurs when the overexpression of one gene becomes lethal, only when combined with the inhibition of another gene (known as the SDL partner). If only one of these two conditions are met, there …
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Nanomechanical Analysis of Coronavirus Spike proteins and Correlation with Infectivity and Lethality
… globally, estimates of infectiousness and lethality of newly emerging strains are important. Here, we provide a novel way to develop a deeper understanding of coronavirus spike proteins, connecting their nanomechanical features – specifically the vibrational spectrum and quantitative …
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A study of lethality and toxic mechanisms of intermittent chlorination to freshwater fish
Most of the literature concerning chlorine deals with continuous exposure, and is not readily applicable to this intermittent release of chlorine. Brungs(1973) reported that very little work has been done on the effects of intermittent exposure on fish, and that temperature has little or no effect …
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A Novel Platform to Perform Cancer-Relevant Synthetic Dosage Lethality Screens in Saccharomyces cerevisiae
The most significant challenge in developing cancer therapies is to selectively kill cancer cells while leaving normal cells unharmed. One approach to specifically target tumors is to exploit gene expression changes specific to cancer cells. For example, synthetic dosage lethal (SDL) interactions …
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Synthetic Lethality of Cdk Inhibition and Doxorubicin In Triple-Negative Breast Cancer Requires P53 Inactivation
<p>Triple-negative breast cancer (TNBC) is an aggressive malignancy in which the tumors lack expression of estrogen receptor, progesterone receptor and HER2. As such, TNBC patients cannot benefit from clinically available targeted therapies and must rely on chemotherapy and surgery for treatment. …
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Identification of Effectors of Synergistic Lethality in Candida albicans-Staphylococcus aureus Polymicrobial Intra-abdominal Infection
… C. albicans and S. aureus leads to synergistic lethality whereas monomicrobial infection is nonlethal. Therefore, we aimed to identify staphylococcal virulence determinants that drive lethal synergism in polymicrobial IAI. Using the toxigenic S. aureus strain JE2, we observed that co-infection …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising …
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Utilizing the IN4MER CRISPR/CAS12A Multiplex Knockout Platform To Investigate Synthetic Lethality in the Human Genome
… achieve in the clinic. The concept of synthetic lethality has gained traction as a promising opportunity to discover novel cancer-specific vulnerabilities and therapeutic targets. Unfortunately, initial technologies for combinatorial genetic perturbation in mammalian cells suffer from …
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Considerations in the development of a survivability/lethality tradeoff submodel for advanced tactical aircraft conceptual design
System dynamics is based on principles borrowed from engineering—especially feedback concepts. It makes possible a representation of decision policies and information flow. The systems approach is a mixture of scientific approaches to conceptualizing problems and solving them through research, …
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Induction of Synthetic Lethality In Mutant Kras Cells For Non-Small Cell Lung Cancers Chemoprevention and Therapy
<p>Lung cancer is the leading cause of cancer death in both men and women in the United States and worldwide. Despite improvement in treatment strategies, the 5-year survival rate of lung cancer patients remains low. Thus, effective chemoprevention and treatment approaches are sorely needed. …
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Investigations into the viral molecular determinants of lethality of Punta Toro virus (Bunyaviridae, phlebovirus) in the Syrian hamster.
… viral genome segment(s) responsible for hamster lethality, this study finds that the S segment can confer lethality independently. Further genetic investigation reveals that the NSs gene encoded by the S segment is a type 1 interferon antagonist. Taken together, this evidence indicates a …
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Comparative Whole-genome and Phenotype Analyses of Virulence Factors and Lethality in Nematode Challenge Assay among Aeromonas isolates
… strains resulted in varying degrees of lethality as measured by nematode survival, and supported the existence of pathotypes; however, no single common virulence factors was found to explain the difference between highly virulent strains and those significantly less virulent. The results …
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Les Temps Roulent: An Analysis of Emergency Medical and Police Response Times to Shootings and Lethality in New Orleans
Lethality of aggravated assaults has long been discussed in terms of weapons used, location of assault, demographics of victims, and regions of the US in which the assault occurred. However, dating back to the 1950s, medical response times have been discussed as a mediating factor, but minimally …
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Falling Down: The Influence Of Traffic Patterns And Availability Of Emergency Medical Service Personnel On The Lethality Of Violent Encounters
… of emergency medical services on the lethality of violent interpersonal encounters. Key situational and contextual factors are controlled using the criminal events perspective. Data were taken from the 2002 National Incident-Based Reporting System of the FBI, as well as from …
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