Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"lethal toxin"”.
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Destabilization of IL-8 mRNA by Anthrax Lethal Toxin: Demonstration of the Requirement for TTP and Examination of its Cellular Interactions
… arms of the host immune response. Its secreted toxin, anthrax lethal toxin (LeTx), causes the accelerated decay of the IL-8 mRNA. IL-8 is a dual function cytokine and chemokine that can recruit and activate neutrophils at the site of infection. Through the inactivation of MAPK pathways, LeTx …
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Clostridium difficile and its toxins
… strains is antigenically uniform? and so is the lethal toxin; 7. and that the 'haemolysin' is almost certainly complex.
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Anthrax toxin effects on B lymphocyte function
… a number of virulence factors of which, the two toxins are of great importance. Lethal toxin is a zinc metaloprotease that cleaves the N terminus of the mitogen-activated protein kinase (MAPK) kinase family 1-7, with the exception of MEK5. This kinase family is responsible for activating the …
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Purification and characterization of Clostridium sordellii toxins HT and LT and comparison to toxins A and B of Clostridium difficile
… It is now known that C. difficile produces two toxins, designated A and B, that are implicated in the pathogenesis of the disease. C. sordellii produces two toxins, designated HT (Hemorrhagic Toxin) and LT (Lethal Toxin), that are similar to toxins A and B of C. difficile. The goal of my …
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Delivery of biomolecules into mammalian cells using anthrax toxin
… non-toxic delivery platform derived from anthrax lethal toxin has been developed to overcome this challenge for the delivery of biomolecules into the cytosol of mammalian cells. The PA/LFN delivery platform has been used to deliver over 30 known biomolecules of diverse sequences, structures, and …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… of Rac with <em> Clostridium difficle </em> toxin B (ToxB) or expression of a dominant negative Rac1 mutant significantly induces activation of the "death executioner" caspase-3 and subsequent apoptosis in primary cerebellar granule neuron (CGN) cultures. We have previously shown that Rac …