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Showing 1 to 2 of 2 for “"lethal mutagenesis"”.
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Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
… deoxycytidine (KP1212), employs the mechanism of lethal mutagenesis to avoid the problem of drug resistance and use the virus's high mutation rate against it. KP1212 is incorporated into DNA by HIV reverse transcriptase (RT) but mispairs with adenine instead of guanine, increasing the rate of …
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Studies On The Determinants Of HIV Mutagenesis And Strategies For Its Enhancement
… However, the precise determinants of viral mutagenesis in HIV-1 and the degree of their contribution to HIV-1 genetic diversity remain incompletely understood. Furthermore, differences in viral mutagenesis among different HIV types (e.g., HIV-1 and human immunodeficiency virus type 2, HIV-2) …