Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"leptin resistance"”.
-
Prenatal and postnatal nutritional influences on leptin sensitivity and susceptibility to diet-induced obesity in the rat
… on the potential mechanistic role of the leptin endocrine axis, the main objective of this thesis was to investigate the long term effects of prenatal undernutrition and different levels of postnatal nutrition on leptin sensitivity and the development of diet-induced obesity (DIO) in the …
-
Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease
… possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance. In paper …
-
Neural Mechanisms of Homeostatic Need and Reward
… the mechanism of how the feeding center develops resistance to leptin, a satiety hormone, and means to reverse it. Diet-induced obese (DIO) mice and obese humans have high circulating levels of leptin and do not respond to the exogenous leptin suggesting that they develop leptin resistance. …
-
The Effect of Steroid Hormones on Expression of the Leptin Receptors
Leptin, a peptide hormone secreted by adipocytes, has been widely studied in the attempt to understand its contributions and relation to obesity. There is a sexual dimorphism in leptin levels between men and women, suggesting a possible influence of steroid hormones on leptin expression and …
-
Body Temperature and Diet As Drivers of Obesity Development
… to gain mechanistic insight into the causes of leptin resistance in obesity. Together, these three projects advance the understanding of how body temperature and diet drive obesity development and provide a rationale for future research geared towards the prevention and treatment of obesity.</p>
-
Investigating the physiological function of BACE1 and its role in metabolism
… the hypothesis that amyloid peptides lead to leptin resistance- a possible contributor to central memory and metabolic impairment. These studies suggest a role for BACE1 in the regulation of cell connectivity and communication, which may underlie the changes in central metabolic and memory …
-
On the role of SOCS proteins in leptin signalling
Leptin is a pleiotropic cytokine that was initially identified as a key player in food intake and energy expenditure. It is produced mainly in adipose tissue and circulating leptin levels correlate well with the amount of body fat. As an adipostat, leptin passes the blood brain barrier to inform …
-
The effects of obesity and surgically-induced weight loss on exercise ventilation: influence of central adiposity and serum leptin
… adults by altering normal ventilatory mechanics. Leptin, an inflammatory adipocytokine, is elevated in obesity and has been shown to alter ventilatory responses to exercise. Leptin’s bioavailability appears to be regulated by its soluble receptor (LRe), which is reduced in obesity. Roux-en-Y …
-
Immunological and behavioral consequences of high-fat diet feeding in mice
… shown and demonstrate here that basal serum leptin and IL-1RA concentrations are increased in mice fed HFD for 12 weeks compared to mice fed LFD. Leptin has been associated with modulation of motivation to obtain reward and anti-depressant activity, and IL-1RA has been implicated in the …
-
The Identification of a Leptin Dependent Neural Pathway Regulating Adipose Tissue Innervation
<p>Leptin, secreted by the adipose tissue, is an afferent signal of a negative feedback loop that regulates body weight balance through its effects on feeding and energy expenditure. Mutations in the leptin gene or its cognate receptor result in severe obesity in both human and mice. My thesis work …