Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"lens epithelial cells"”.
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Peptide nanovesicles: supramolecular assembly of branched amphiphilic peptides
… in these assemblies and delivered into human lens epithelial cells and MCF-7 cells grown on coverslips. Besides fluorescent dyes, we have delivered the plasmid (EGFP-N3, 4.7kb) into N/N 1003A lens epithelial cells and observed expression of EGFP (in the presence and absence of a selection …
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The role of estrogen and superoxide dismutase in cataractogenesis
Cataract is an opacification of the eye lens, constituting the major cause of blindness globally. Oxidative stress is a key factor in the formation of cataract and female gender is a known risk factor for age-related cataract. The aim of this thesis was to investigate the role of estrogen and the …
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Characterization of the unfolding, refolding, and aggregation pathways of two protein implicated in cataractogenesis : human gamma D and human gamma S crystallin
… are major proteins of the human eye lens and are components of cataracts. H[gamma]D-Crys is expressed early in life in the lens cortex while H[gamma]S-Crys is expressed throughout life in the lens epithelial cells. Both are primarily β-sheet proteins made up of four Greek keys …
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Functions of connexin 46 in lens and solid tumors during hypoxia
Eukaryotic cells possess a unique way to communicate with each other by passing metabolites and small molecules through protein pores that connect adjacent cells. Although there are many types and families of protein pores, connexins comprise a unique family. Six connexin monomers assemble into a …
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The role of 4-hydroxynonenal in cellular signaling mechanisms
… widespread and involve several processes. Using lens epithelial cells (HLE B-3) and retinal pigment epithelial cells (RPE28 SV4) as models, in proposed studies we addressed the hypothesis that a physiological level of LPO product 4-hydroxynonenal (HNE) is necessary for maintaining key …
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From mice to men - astrocytes and neural progenitor cells in neural plasticity and regeneration
… some reactive astrocytes can act as neural stem cells after injury. We hypothesized that some reactive astrocytes within the epileptic foci of patients with epilepsy have neural progenitor cell properties. We studied material from surgical resections from patients with pharmacologically …
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Regulation of cataractogenesis in cultured bovine lenses by hydrogen sulfide donors
… sulfide (H2S) on cataractogenesis. Bovine lenses were cultured in DMEM with AA (positive control) or compounds [L-cysteine, diallyl trisulfide (DATS) and GYY 4137 (GYY)] in presence or absence of hydrogen peroxide (H2O2). Lens light transmittance and optical clarity were assessed and …
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Investigating the putative therapeutic effects of sulfophane in the human lens
Purpose: Cataract (a clouding of the lens) and PCO, a lens wound-healing response that occurs following cataract surgery, are important medical problems affecting millions worldwide. Reducing the incidence of these conditions would have a marked effect on the personal well being of millions of …