Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"leaky gut"”.
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miR-10b Rescues Diabetes and GI Dysmotility Associated with a Leaky Gut
… resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves multiple critical functions for their hosts, including regulating host immunity, procuring energy from food, and preventing the colonization of pathogens. Mounting evidence has …
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A microphysiological system for studying barrier health of live tissues in real time
… in the body from their external environment. The gut in particular carries bacteria and other infectious agents. A healthy gut epithelial barrier prevents unwanted substances from accessing the underlying lamina propria while maintaining the ability to digest and absorb nutrients. Increased gut …
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The role of gut microbiota in systemic lupus erythematosus
… have been implicated in the disease mechanisms. Gut microbiota as an environmental factor and the immune system interact to maintain tissue homeostasis, but whether this interaction is involved in the pathogenesis of SLE is unclear. In a classical model of lupus nephritis, MRL/lpr, we found …
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The Influence of Heat Stress on Milk Yield, Gastrointestinal Permeability, and Nutrient Partitioning in Lactating Dairy Cattle
The US dairy industry loses approximately $1.2 billion due to heat stress related production losses annually. It was formerly believed that heat-stressed lactating dairy cattle produce less milk because they consume less feed. It has since been established that the reduction of feed intake is only …
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Molecular Determinants of TRP Channel Gating
… conditions, including hyperalgesia, gut barrier dysfunction, and ataxia. Thermal hyperalgesia is a condition in which previously innocuous stimuli become painful as a result of inflammatory responses. TRP Vanilloid member 1 (TRPV1) is a contributor to this process due to its …
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Role of antiretroviral therapy exposure host genetics on cytomegalovirus infection status and association with gut microbiome profiles among pregnant black African women
… CMV has a wide host cell tropism that includes gut epithelial cells. CMV infection in the gut epithelial cells results in a leaky gut and potential gut microbial dysbiosis. In this study, we set out to determine the prevalence of CMV infection as well as factors associated with CMV reactivation …
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REGULATION AND EXPRESSION OF AMYLOID CURLI IN SALMONELLA INFECTION
… bacteria express curli and form biofilms in the gut during infection due to the contrasting conditions between life outside versus inside the host. However, there is indirect evidence in support of curli expression in both humans and mice during infection. Furthermore, bacterial infections are …
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
… with tRA reversed the pristane-induced leaky gut and similarly modulated the gut microbiota, suggesting a gut microbiota-independent mechanism by which tRA affects the initiation vs. continuation phase of lupus. As tRA could be protective against lupus nephritis especially during the …