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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 5 of 5 for “"leak channels"”.

  1. The Role of Neuronal Leak Channels in Anesthesia

    Singaram, Vinod KrishnanCase Western Reserve University School of Graduate Studies2012

    … sodium (NCA or NALCN) and potassium (K2P) leakchannels that establish the neuronal resting membrane potential (RMP). Usingthe nematode, C. elegans, I tested the effect on anesthetic sensitivity ofcombining these potassium and sodium leak channel mutations in a singleanimal. I also used the …

    ohiolink Repository record

  2. Novel Optical Tools to Investigate Presenilin Control of Neurotransmission

    Farrell, Ryan J

    … that Presenilins are ER Ca<sup>2+</sup> leak channels to determine if a role in ER Ca<sup>2+</sup> leak can explain the previously described regulation of neurotransmission by Presenilins. While Presenilins are best known for their involvement in Alzheimer's Disease, this potential …

    rockefeller Repository record

  3. Regulation of a two-pore K+ channel by multiple subunits in Caenorhabditis elegans

    Perez de la Cruz, Ignacio, 1973-Massachusetts Institute of Technology2002

    K+ channels generate and tune the electrical signals that underlie the functioning of neurons and other excitable cells. We have studied a set of genetically-interacting genes, sup-9, sup-10 and unc-93, whose products are predicted to form a protein complex that when misregulated leads to severe …

    mit Repository record

  4. A quantitative study of neuronal calcium signaling

    Hartsfield, Jane WallRice University2006

    … calcium transports (voltage-gated calcium channels, pumps, exchangers, and store-operated channels), and ER calcium transports (IP3 receptors, ryanodine receptors, pumps, leak channels) to show that calcium waves initiate in the apical trunk at the point where the stimulated oblique …

    rice Repository record

  5. Familial Alzheimer's Disease Mutations in Presenilins Disrupt Endoplasmic Reticulum Calcium Leak

    Nelson, Omar Lloyd2010

    … function as endoplasmic reticulum (ER) Ca2+ leak channels and that FAD mutations in presenilns affected this function. Our findings potentially provided an explanation for Ca2+ signaling abnormalities resulting from FAD mutations in presenilins. The goal of my thesis project is to establish a …

    utswmed Repository record