Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"leader cells"”.
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Cooperative Invasion Between Tumor Cell Subpopulations
… cascade which can occur collectively by multiple cells cooperatively invading into the surrounding stroma. Primary patient breast tumors and patient-derived breast cancer cells can collectively invade yet how cells collectively invade is still largely unknown. It is well known that tumors contain …
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The mechanisms underlying mechanical cell competition and leader cell migration in mammalian epithelia
… that results in the elimination of less fit cells from a tissue by their fitter counterparts. I take advantage of an established in vitro model of cell competition using Madin-Darby canine kidney (MDCK) cells to shed insight into the molecular basis of cell competition in epithelial cells. In …
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Compressive stress enhances coordinated migration of mammary carcinoma cells
… compressive stress experienced by cancer cells in vivo, we developed an in vitro compression device for compressing a monolayer of cancer cells with precisely-defined normal forces. Here we show, for the first time, that externally-applied compressive stress resulted in faster migration of …
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Breast cancer cells cooperate during invasion and metastasis
… is a multistep process during which cancer cells leave the primary tumor, invade and seed inside secondary tissues, leading to lethal organ failure. Currently, no efficient method exists for the elimination of invasive cancer cells, which poses a major clinical challenge. Indeed, while …